| 2 | 个体化癫痫治疗管理的新时代显示文摘关国良及同事探讨认为,癫痫治疗的试错法已有一个多世纪没有改变,但机器学习和患者衍生的干细胞有望提供一种个体化且更有效的治疗策略。癫痫影响了全世界5000万人,没有年龄、种族或地域上的界限1。患者反复癫痫发作,可导致损伤、认知能力下降、社会心理功能障碍,甚至死亡。癫痫是由脑损伤,如创伤、卒中、肿瘤、炎症和感染,以及基因组变异导致的系统性变化而引起的。癫痫患者会有更多的合并症,包括脑血管疾病、神经认知疾病和精神疾病2。因此更好的控制癫痫将改善整体脑健康。 | Zhibin Chen Ben Rollo Ana Antonic-Baker Alison Anderson 马远林 Terence J O′Brien Zongyuan Ge 王学峰 关国良 | 2021 | 英国医学杂志中文版2021，24，1： | 0 |
| 3 | Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis显示文摘Background: Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic func-tion early in the course of disease in a transgenic mouse with doxycycline (Dox)-controlled expression of cytoplasmic human TDP-43 (hTDP-43ΔNLS), mimicking the key pathology implicated in ALS. Methods: Adult TDP-43 transgenic and littermate monogenic control mice underwent longitudinal multimodal MRI one and three weeks after the cessation of Dox feed, together with weekly rotarod assessments of motor per-formance. Glymphatic function was assessed using dynamic contrast-enhanced MRI to track the clearance of an MR contrast agent injected into the cisterna magna. Results: Compared to their littermate controls, TDP-43 mice exhibited progressive neurodegeneration including that within the primary motor cortex, primary somatosensory cortex and corticospinal tract, significant weight loss includ-ing gastrocnemius atrophy, and shortened telomere length. Furthermore, in the presence of this ALS-like phenotype, these mice have significantly disrupted glymphatic function. Conclusions: Although the relationship between glymphatic clearance and ALS disease progression remains to be elucidated, these changes occurred very early in the disease course. This provides initial evidence to suggest that the glymphatic system might be a potential therapeutic target in the treatment of ALS. | Akram Zamani Adam K.Walker Ben Rollo Katie L.Ayers Raysha Farah Terence J.O’Brien David K.Wright | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
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