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		题名	作者	年代	出处	被引量
	1	Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.	Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters	2009	World Journal of Gastroenterology2009，15，28：	11
	2	Three-dimensional structure of myosin subfragment-1 : a molecular motor显示文摘	Rayment I Rypniewski WR Schmidt-Base K Smith R Tomchik DR Benning MM Winkelmann DA Wesenberg G Holden HM	1993	Science1993，261，：	1
	3	Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase显示文摘	PEDERSEN LC BENNING MM HOLDEN HM	1995	Biochemistry1995，34，13：	1
	4	Aortic stent migration: a rare complication after endovascular repair 显示文摘	Kaouel K Ben HM Ben MM	2014	J Mal Vasc2014，39，3：	1
	5	Clinical manifesta- tions and treatment outcome of optic neuropathy in thyroid-relat- ed orbitopathy 显示文摘	Ben Simon GJ Syed HM Douglas R	2006	Ophthalmic Surg Lasers Imaging2006，37，4：	1
	6	Extraocular muscle enlargement with tendon involvement in thyroid-associated orbitopathy显示文摘	Ben Simon GJ Syed HM Douglas R	2004	Am J Ophthalmol2004，137，6：	1
	7	Extraocular muscle enlargement with tendon involvement in thyroid-associated orbi- topathy显示文摘	Ben Simon GJ Syed HM Douglas R	2004	Am J Ophthalmol2004，137，6：	1
	8	Menopausal age,related factors and climacteric symptoms in Libyan women显示文摘	Taher YA1 Ben Emhemed HM Tawati AM	2013	Climacteric2013，16，：	1
	9	Strabismus after deep lateral wall orbital decompression in thyroid-related or- bitopathy patients using automated hess screen显示文摘	BEN SIMON GJ SYED HM LEE S	2006	Ophthalmolo- gy2006，113，6：	1
	10	Epidemic West Nile virus encephalitis in Tunisia显示文摘	Feki I Marrakchi C Ben HM	2005	Neuroepidemiology2005，24，12：	1
	11	An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes显示文摘	Kandi CM Ben HM	2006	Reproduction2006，132，1：	1
	12	Placental leptincorrelates with intrauterine fetal growth and development显示文摘	Ben XM Qin YN Wu HM	2001	Clin Med J2001，114，6：	1

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