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| 1 | Diagnostic and therapeutic management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an increasing health problem, representing the second cause of cancerrelated mortality worldwide. The major risk factorfor HCC is cirrhosis. In developing countries, viral hepatitis represent the major risk factor, whereas in developed countries, the epidemic of obesity, diabetes and nonalcoholic steatohepatitis contribute to the observed increase in HCC incidence. Cirrhotic patients are recommended to undergo HCC surveillance by abdominal ultrasounds at 6-mo intervals. The current diagnostic algorithms for HCC rely on typical radiological hallmarks in dynamic contrast-enhanced imaging, while the use of α-fetoprotein as an independent tool for HCC surveillance is not recommended by current guidelines due to its low sensitivity and specificity. Early diagnosis is crucial for curative treatments. Surgical resection, radiofrequency ablation and liver transplantation are considered the cornerstones of curative therapy, while for patients with more advanced HCC recommended options include sorafenib and trans-arterial chemoembolization. A multidisciplinary team, consisting of hepatologists, surgeons, radiologists, oncologists and pathologists, is fundamental for a correct management. In this paper, we review the diagnostic and therapeutic management of HCC, with a focus on the most recent evidences and recommendations from guidelines. | Francesco Bellissimo Marilia Rita Pinzone Bruno Cacopardo Giuseppe Nunnari | 2015 | World Journal of Gastroenterology2015，21，42： | 18 |
| 2 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Maria I. Bellissimo Débora Amado Dulcinéia S.P. Abdalla Edimar C. Ferreira Esper A. Cavalheiro Maria da Gra?a Naffah-Mazzacoratti | 2001 | Epilepsy Research2001，，2： | 1 |
| 3 | Superoxide dismutase,glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Bellissimo MI Amado D Abdalla DS | | 0，，02： | 1 |
| 4 | Achromobacter xylosoxidans meningitis in an immunosuppressed patient显示文摘 | Bellissimo F Pinzone M R Tosto S | 2014 | QJM2014，107，1： | 1 |
| 5 | An after-school snack of raisins lowers cumulative food intake in young children显示文摘 | Patel B P Bellissimo N Luhovyy B | 2013 | Journal of Food Science2013，，： | 1 |
| 6 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Bellissimo MI Amado D Abdalla DS | 2001 | Epilepsy Res2001，46，2： | 1 |
| 7 | Comparison of bilaterally 6-OHDA-and MPTP-lesioned rats as models of the early phase of Parkinson's disease:histological,neurochemical,motor and memory alterations显示文摘 | Ferro MM Bellissimo MI Anselmo-Franci JA | 2005 | Neurosci Methods2005，148，： | 1 |
| 8 | Superoxide dismutase,glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Bellissimo MI Amado D Abdalla DS | 2001 | Epilepsy Res2001，46，2： | 1 |
| 9 | Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers 显示文摘 | Skogen B Bellissimo DB Hessner M J Santoso S Aster RH Nevman PJ McFarland JG | 1994 | Transfusion1994，34，： | 1 |
| 10 | Superoxide dismutase,glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Bellissimo MI Amado D Abdalla DS | 2001 | Epilepsy Res2001，46，2： | 1 |
| 11 | Achromobacter xylosoxidans meningitis in an immunosuppressed patient 显示文摘 | Bellissimo F Pinzone M R Tosto S | 2014 | QJM2014，107，1： | 1 |
| 12 | 显示文摘 | Bellissimo DB Uzgiris AJ | 2000 | Mol Diagn2000，5，： | 1 |
| 13 | Effect of television viewing at mealtime on food intake after a glucose preload in boys 显示文摘 | BELLISSIMO N PENCHARZ PB THOMAS SG | 2007 | Pediatr Res2007，61，6： | 1 |
| 14 | Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding ni-trate reductase,a metalloflavoprotein with three functional domains显示文摘 | CRAWFORD N M SMITH M BELLISSIMO D | 1988 | Proceedings of the National Academy of Sciences1988，85，14： | 1 |
| 15 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats 显示文摘 | Bellissimo MI Amado D Abdalla DS | 2001 | Epilepsy Res2001，46，2： | 1 |
| 16 | Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson' s disease : histological,neurochemical,motor and memory alterations 显示文摘 | Ferro MM Bellissimo MI Anselmo-Franci JA | 2005 | J Neurosci Methods2005，148，1： | 1 |
| 17 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats 显示文摘 | Bellissimo M I Amado D Abdalla D S | 2001 | Epilepsy Res2001，46，2： | 1 |
| 18 | Comparison of bilaterally 6-OHDA and MPTP-lesioned rats as models of the early phase of Parkinson’s disease:histological,neuro-chemical,motor and memory alterations显示文摘 | Ferro MM Bellissimo ML Anselmo-Franci JA | 2005 | J Neurosci Methods2005，148，1： | 1 |
| 19 | Fourier transform infrared spectroscopic studies of plasma protein adsorption under well-defined flow conditions 显示文摘 | Bellissimo JA Cooper SL | 1984 | Trans Am Soc Artif Intern Organs1984，30，： | 1 |
| 20 | Rapid determination of platelet alloantigen genotypes by polymerase chain reaction using allele-specific primers显示文摘 | Skogen B Bellissimo DB Hessner MJ | 1994 | Transfusion1994，34，： | 1 |
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