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| 1 | Epstein-Barr virus and Burkitt lymphoma显示文摘In 1964,a new herpesvirus,Epstein-Barr virus(EBV),was discovered in cultured tumor cells derived from a Burkitt lymphoma(BL)biopsy taken from an African patient.This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers.Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells,and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene.These results hinted at simple oncogenic mechanisms that would make Burkitt lymphoma paradigmatic for cancers with viral etiology.In reality,the pathogenesis of this tumor is rather complicated with regard to both the contribution of the virus and the involvement of cellular oncogenes.Here,we review the current understanding of the roles of EBV and c-MYC in the pathogenesis of BL and the implications for new therapeutic strategies to treat this lymphoma. | Martin Rowe Leah Fitzsimmons Andrew I Bell | 2014 | Chinese Journal of Cancer2014，33，12： | 14 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR显示文摘 | Bell DW Gore I Okimoto RA | 2005 | Nat Genet2005，37，12： | 1 |
| 4 | Steady-state studies显示文摘 | Michael D Rhodes Bell Alexis T The effects of zirconia morphology on methanol synthesis from CO and H2 over Cu/ZrO2 catalysts Part I | 2005 | Journal of Catalysis2005，233，： | 1 |
| 5 | Raman spectroscopic library of natural and synthetic pigments (pre-- 1850 AD)显示文摘 | Bell I M Clark R J H Gibbs P J | 1997 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy1997，53，12： | 1 |
| 6 | Raman spectroscopic library of natural and synthetic pigments (pre- 1850AD) 显示文摘 | Bell I M Clark R J H Gibbs P J | 1997 | Spectrochim Acta Part A: Mol Biomol Spectr1997，53，12： | 1 |
| 7 | Performance of vapor compression systems with compressor oil flooding and regeneration显示文摘 | BELL I H GROLL E A BRAUN J E | 2011 | International Journal of Refrigeration2011，34，： | 1 |
| 8 | Apolipoprotein E con- trols eerebrovascular integrity via eyelophilin A显示文摘 | Bell RD Winkler EA Singh I | 2012 | Nature2012，485，7399： | 1 |
| 9 | Foreign IPO capital market choice:understanding the institutional fit of corporate governance 显示文摘 | MOORE C B BELL G FILATOTCHEV I RASHEED A A | 2012 | Strategic Management Journal2012，33，8： | 1 |
| 10 | Quantification of DeQi sensation by visual analog scales in healthy humans after immunostimulating acupuncture treatment显示文摘 | Kou W Gareus I Bell JD | 2007 | Am JChin Med2007，35，5： | 1 |
| 11 | p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53 - dependent apoptosis 显示文摘 | de Belle I Huang RP Fan Y | 1999 | Oncogene1999，18，24： | 1 |
| 12 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
| 13 | The neuropathology of HIV/AIDS 显示文摘 | ANTHONY I C BELL J E | 2008 | Int Rev Psychiatry2008，20，1： | 1 |
| 14 | Down-modulation of the costimulatory molecule CD28 is a conserved activity of multiple SIV Nef and is dependent on histidine 196 of Nef显示文摘 | Bell I Schaefer TM Trible RP | 2001 | Virology2001，283，1： | 1 |
| 15 | Inherited susceptibility to lung cancer may be associated with the T790M drug resis- tance mutation in EGFR显示文摘 | Bell DW Gore I Okimoto RA | 2005 | Nat Genet2005，37，12： | 1 |
| 16 | Alarm fatigue linked to patient's death - Interview by Laura Wallis 显示文摘 | I Bell L | 2010 | Am J Nuts2010，110，7： | 1 |
| 17 | Human epidermal growth factor precursor:cDNA sequence,expression in vitro and gene organization显示文摘 | Graeme I Bell Noel M Fong Michelle M Stempien | 1986 | Natl Acid Research1986，14，21： | 1 |
| 18 | The Densification of Granular Soils Using Vibro methods 显示文摘 | Slocomb B C Bell A L Baez J I | 2000 | Geotechnique2000，50，6： | 1 |
| 19 | The transcription factor EGR-1 suppresses transformation of human fibrosareoma HT1080 cells by coordinated induction of transforming growth factorbl ,ibronectin,and plasminogen activator inhibitor-1 显示文摘 | Liu C Yao J de Belle I | 1999 | J Biol Chem1999，274，7： | 1 |
| 20 | Molecular properties-of somatostatin receptors显示文摘 | Reisine T Bell G I | 1995 | Neuroscience1995，67，4： | 1 |
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