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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Early prediction of endocrine therapy effect in advanced breast cancer patients using ^99mTc-depreotide scintigraphy 显示文摘 | VAN DEN BOSSCHE B VAN BELLE S DE WINTER F | 2006 | J Nucl Med2006，47，11： | 1 |
| 3 | Positional enhancer-blocking activity of the chickenβ-globin 5'HS4 insulators in transiently transfected cells显示文摘 | Recillas-Targa F Bell AC Felsenfeld G | 1999 | Proc Nail Acad Sci USA1999，96，14： | 1 |
| 4 | Development of broodstock diets for the European sea bass (Dicentrarchus labrax)with special emphasis on the importance of n-3 and n-6 HUFA to reproductive performance 显示文摘 | Bruce M P Oyen F Bell J G | 1999 | Aquaculture1999，177，： | 1 |
| 5 | Microarray analys is of rat brain gene expression after chronic administration of sodium valproate 显示文摘 | Bosetti F Bell JM Manickam P | 2005 | Brain Res Bull2005，65，4： | 1 |
| 6 | Assessment of cement o-PFA and lime-PFAused to stabilizer clay-size materials显示文摘 | Bell F G | 1994 | Bulletin of theIntermational Association of Engineering Geology1994，，49： | 1 |
| 7 | Prostaglandin ( F and E, 2-and 3-series) production and cy- clooxygenase (COX-2) gene expression of wild and cultured broodstock of Senegalese sole (Solea senegalensis) 显示文摘 | NORAMBUENA F MACKENZIE S BELL J G | 2012 | General and Comparative Endocrinology2012，177，2： | 1 |
| 8 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 9 | Free metal activity and total metal concentrations as indices of micronutrient availability to barley (Hordeum rulgure(L) 'Klages')显示文摘 | Bell P F Chaney R L Angle J S | 1991 | Plant and Soil1991，130，： | 1 |
| 10 | Simple and Reliable Method of Doxyeycline Determination in Human Plasma and Biological Tissues 显示文摘 | Axisa B Naylor A R Bell P R F | 2000 | J Chromatogr B2000，744，2： | 1 |
| 11 | NF-κB is activated during acute inflammation in vivo in association with molecule gene expression and leukocyte recruitment显示文摘 | BELL F P ROSENBLOOM J G | 1995 | J Inflamm1995，45，4： | 1 |
| 12 | Isolation of thermophiles from broadleaf tobacco and effect of pure culture inoculation on cigar aroma and mildness显示文摘 | English C F Bell E J Berger A J | 1967 | Application Microbiology1967，15，： | 1 |
| 13 | Cancellation of GLONASS signals from radio astronomy da- ta 显示文摘 | ELLINGSON Steven W BUNTON John D BELL Jon F | 2009 | The Smithsonian/NASA Astrophysics Data System2009，4015，： | 1 |
| 14 | Rep-PCR-mediated genomic fingerprinting:a rapid and effective method to identify Clavibacter michiganensis显示文摘 | Louws F J Bell J Medina-Mora C M | 1998 | Phytopathology1998，88，： | 1 |
| 15 | Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries显示文摘 | Maillard L Van Belle E Rio F | 2000 | Gene Ther2000，7，16： | 1 |
| 16 | Sampling errors in the estimation of empirical orthogonal functions显示文摘 | NORTH G R BELL T L CAHALAN R F | 1982 | Mon Wea Rev1982，110，7： | 1 |
| 17 | Protective effects of Syzygium cumini seed extract against methylmercury induced sistemic toxicity in neonatal rats显示文摘 | ABDALLA F H BELLE L P BITENCOURT P E R | 2011 | Biometals2011，24，2： | 1 |
| 18 | Prevention of tamoxifen induced endometrial polyps using a levonorgestrel releasing intrauterine system long-term follow-up of a randomised eontrol trial 显示文摘 | Gardner F J Konje JC Bell SC | 2009 | Gyneeol Oncol2009，114，3： | 1 |
| 19 | In-plane vibration of annular rings显示文摘 | Ambati G Bell J F W Sharp J C K | 1976 | Journal of Sound and Vibration1976，47，： | 1 |
| 20 | The Relation of The Structure of Common Stock Prices to Historical, Expectation and Industrial Variables 显示文摘 | Bell F W | 1974 | Journal of Finance1974，29，1： | 1 |
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