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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Practice guideline for the treatment of patients with acute stress disorder and postt- raumatic stress disorder显示文摘 | Ursano RJ Bell C Eth S et ai | 2004 | Am J Psychiatry2004，161，11： | 1 |
| 3 | Residues of oxytetracycline in cultured juvenile blue shrimp, Penaeus stylirostris( Crustacea: Decapod) , fed medicated feed for 14 days 显示文摘 | Mohney L L Willams R R Bell T A et aI | 1997 | J Aquat Anim health1997，149，： | 1 |
| 4 | Analysis of Epstein-Barr virus latent gene expression in endemic Burkitt's lymphoma and nasopharyngeal carcinoma turnout cells by using quantitative real-time PCR assays显示文摘 | Bell AI Groves K Kelly GL | 2006 | J Gen Virol2006，87，10： | 1 |
| 5 | Therapies for diabetic dyslipidae- mia显示文摘 | Bell DS AI Badarin F Keefe JH Jr | 2011 | Diabetes Obes Metab2011，13，： | 1 |
| 6 | Carrier testing for severe childhood recessive diseases by next-generation sequencing显示文摘 | Bell CJ Dinwiddie DL Miller NA et aI | 2011 | Sci Transl Med2011，3，65： | 1 |
| 7 | Therapies for diabetic dyslipidaemia显示文摘 | Bell DS AI Badarin F O′Keefe JH Jr | | 0，，： | 1 |
| 8 | Epstein-barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes显示文摘 | CHAGANTI S BELL AI PASTOR NB | 2005 | Blood2005，106，13： | 1 |
| 9 | The European Can- cerAnaemiaSurvey ~CAS):alarge,multinational, prospective survey defining the prevalence,incidence,and treatment of anemia in cancer patients显示文摘 | Ludwig H Van Belle S Barren-Lee P et aI | 2004 | Eur J Cancer2004，40，15： | 1 |
| 10 | A hyperbaric oxygen:its uses, mechanisms of action and oulcomes显示文摘 | Gill AI Bell CN | 2004 | Q J Med2004，97，7： | 1 |
| 11 | ACR guidance document for safe MR practices : 2007显示文摘 | Kanal E Barkovich AI Bell C | 2007 | AIR Am J Roentgenol2007，188，6： | 1 |
| 12 | Aspirin inhibits surface glycoprotein Ⅱ b/Ⅱ a, P-selectin, CD63, and CD107a receptor expression on human platelets 显示文摘 | McKenzie ME Malinin AI Bell CR | 2003 | Blood Coagul Fibrinolysis2003，14，3： | 1 |
| 13 | Mild in vitro trauma induces rapid GIuR2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells显示文摘 | Bell JD Ai J Chen Y | 2007 | Brain2007，130，0： | 1 |
| 14 | Epstein-Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients显示文摘 | Chaganti S Ma CS Bell AI | 2008 | Blood2008，112，3： | 1 |
| 15 | Stage-specific inhibition of MHC classlpresentation by the Epstein-Ban' virus BNI22a pro- tein during virus lytic cycle显示文摘 | Croft NP Shannon-Lowe C Bell AI | 2009 | PLoS Pathog2009，5，10： | 1 |
| 16 | Procaspase 3 expression in ovarian carcinoma cells increases survivin transcription which can be countered with a dominant-negative mutant, survivin T34A;a combination gene therapy strategy显示文摘 | McKay TR Bell S Tenev T et aI | 2003 | Oncogene2003，22，： | 1 |
| 17 | Mild in vitro trauma induces rapid Glur2 endocytosis,robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells显示文摘 | Bell JD Ai J Chen Y | 2007 | Brain2007，130，10： | 1 |
| 18 | A comparison of MRI and clinical examination of acute lateral ankle sprains显示文摘 | Frey C Bell J Teresi L et aI | 1996 | Foot Ankle Int1996，17，： | 1 |
| 19 | Genotype/ phenotype discord-ance for human arylamine N - acetyl transferase ( NAT2 ) reveals anew slow - Acetylalor allele common in African - Americans 显示文摘 | Bell DA Taylor J A Butler MA et ai | 1993 | Carcinogenesis1993，14，： | 1 |
| 20 | Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats显示文摘 | Stratmann G Sail JW Bell JS et ai | 2010 | Anesthesiology2010，112，2： | 1 |
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