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| 1 | Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death显示文摘 | Jiang H Gomez-Manzano C Aoki H Alonso MM Kondo S McCormick F Xu J Kondo Y Bekele BN Colman H Lang FF Fueyo J | 2007 | 中国神经肿瘤杂志2007，5，3： | 24 |
| 2 | Recent advances in targeting the autotaxin-lysophosphatidate-lipid phosphate phosphatase axis in vivo显示文摘Extracellular lysophosphatidate(LPA) is a potent bioactive lipid that signals through six G-protein-coupled receptors.This signaling is required for embryogenesis,tissue repair and remodeling processes.LPA is produced from circulating lysophosphatidylcholine by autotaxin(ATX),and is degraded outside cells by a family of three enzymes called the lipid phosphate phosphatases(LPPs).In many pathological conditions,particularly in cancers,LPA concentrations are increased due to high ATX expression and low LPP activity.In cancers,LPA signaling drives tumor growth,angiogenesis,metastasis,resistance to chemotherapy and decreased efficacy of radiotherapy.Hence,targeting the ATX-LPA-LPP axis is an attractive strategy for introducing novel adjuvant therapeutic options.In this review,we will summarize current progress in targeting the ATX-LPA-LPP axis with inhibitors of autotaxin activity,LPA receptor antagonists,LPA monoclonal antibodies,and increasing low LPP expression.Some of these agents are already in clinical trials and have applications beyond cancer,including chronic inflammatory diseases. | Matthew G.K. Benesch Xiaoyun Tang Ganesh Venkatraman Raie T. Bekele David N. Brindley | 2016 | The Journal of Biomedical Research2016，30，4： | 9 |
| 3 | 恩诺沙星在鲫鱼肝微粒体中的代谢及代谢关键酶显示文摘抗生素因具有抗菌谱广、杀菌性强等特点而被广泛应用于人类医药、畜牧业、农业和水产养殖业。其进入水生生物体内后,会在药物代谢酶的作用下发生代谢转化,产生生态毒性。采用鲫鱼肝微粒体体外孵育法,探究恩诺沙星细胞色素P450酶作用下的代谢转化过程,并通过代谢抑制实验确定关键的代谢酶。结果表明,恩诺沙星体外代谢过程符合一级动力学方程,当恩诺沙星暴露浓度为1 mg·L^-1时,其在肝微粒体中的消除速率常数(k)最大为0.00303 min^-1,半衰期(t1/2)最短为228.8 min,应用高效液相色谱串联质谱(HPLC-MS/MS)技术,检测到了恩诺沙星脱乙基产物和羟基化产物;代谢抑制实验结果表明,CYP3A4在恩诺沙星代谢过程中起主要作用,是恩诺沙星代谢的关键酶。本研究结果为深入了解恩诺沙星在水生生物体内的代谢转化及其生态风险提供了基础数据。 | 刘婉玉 Tadiyose Girma Bekele 赵洪霞 | 2020 | 生态毒理学报2020，15，3： | 6 |
| 4 | Plant community and ecological analysis of woodland vegetation in Metema Area,Amhara National Regional State,Northwestern Ethiopia显示文摘We studied woodland vegetation in broad-leaved deciduous woodlands of Metema in northwestern Amhara regional state,Ethiopia to determine plant community types and species distribution patterns and their relationships with environmental variables,including altitude,pH,cation exchange capacity,electrical conductivity(EC),and moisture.We used a selective approach with a systematic sampling design.A total of 74 quadrats,each 25m × 25m at intervals of 150 200 m were sampled along the established transect lines.For herbaceous vegetation and soil data collection,five subquadrats each 1m × 1m were established at the four corners and the center of each quadrat.Three community types were identified using TWINSPAN analysis.All three community types showed high diversity(Shannon-Weiner index),the highest in community type II at 3.55.The highest similarity coefficient was 0.49(49%) between community types II and III,reflecting 0.51(51%) dissimilarity in their species richness.The canonical correspondence ordination diagram revealed that the distribution pattern of community type I was explained by moisture while that of community types III and II was explained by EC and altitude and moisture,respectively.Altitude was the most statistically significant environmental variable,followed by moisture and EC in determining the total variation in species composition and distribution patterns while pH and cation exchange capacity were non significant.In conclusion,we recommend that any intervention should take into account these three discrete community types and their environmental settings to make the intervention more successful. | Haile Adamu Wale Tamrat Bekele Gemedo Dalle | 2012 | Journal of Forestry Research2012，23，4： | 5 |
| 5 | Floristic diversity, regeneration status, and vegetation structure of woodlands in Metema Area, Amhara National Regional State, North-western Ethiopia显示文摘We studied woodland vegetation in broad-leaved deciduous woodlands of Metema in northwestern Amhara regional state, Ethiopia Our objective was to describe plant species composition, diversity, regeneration status, and population structure by a selective approach with asystematic sampling design. A total of 74 quadrats (each for 25 m × 25 m,spaced at intervals of 150 200 m) were sampled along established transect lines following the homogeneity of the vegetation. Vegetation data including cover-abundance, height, diameter at breast height (DBH), and numbers of seedlings and saplings of woody species were analyzed using Excel spreadsheet, Shannon Weiner diversity index, and PAST version 1.62. A total of 87 vascular plant species of 74 genera and 36 families were recorded. The dominant family was Fabaceae represented by 16(18.39 %) species of 13 genera. Shannon Weiner diversity and evenness were 3.67 and 0.82, respectively, which showed that the area was endowed with rich floral diversity evenly distributed. The vegetation structure, as quantified by cumulative diameter class frequency distribution,plotted as an interrupted inverted-J-shape pattern with a sharp decreasein the 2nd diameter class. This indicated poor vegetation structure. The diameter classes frequency distributions of selected species plotted infour general patterns i.e., interrupted Inverted-J-shape, J-shape,Bell-shape and Irregular-shape. In conclusion, although the area showedhigh floral diversity and evenness, woody species including Sterculea setigera, Boswellia papyrifera, and Pterocarpus lucens showed lowest recruitment of seedlings and saplings. | Haile Adamu Wale Tamrat Bekele Gemedo Dalle | 2012 | Journal of Forestry Research2012，23，3： | 4 |
| 6 | 埃塞俄比亚金属矿产资源综述显示文摘在大量查阅、深刻分析国内外中英文文献以及实地野外调查踏勘的基础上,对埃塞俄比亚国家的金属矿产资源进行了较为详细地概述。研究表明,该国金属矿产资源主要分布在西部、北部和南部绿岩带。从前寒武纪到近代构造构成了埃塞俄比亚地质学的基础。其中低级变质火山沉积岩组合赋存了绝大多数经济矿床,包括金、铂族元素、镍、贱金属(Cu、Pb、Zn)、磷酸盐、铁等,并且其中生代沉积岩含有天然燃料矿产和一些金属矿产如孔雀石、锰矿石和含石膏矿物。分析发现埃塞俄比亚金属矿产资源具有良好的开采和开发前景,特别是金、铂等贵金属,镍等黑色金属,铜等有色金属,铌、钽等稀有金属,铀(钍)等放射性金属。 | 杨波涌 鲍征宇 董志成 Sisay Ayalew Amera Yonas Bekele | 2011 | 资源与产业2011，13，6： | 3 |
| 7 | Effects of nitrogen, phosphorus and vermicompost on groundnut yield in Babile District, eastern Ethiopia显示文摘Groundnut is a major cash crop for smallholder farmers in several districts of eastern Ethiopia with low yield. Little or no fertilizer was applied for the crop possibly because no generic or recommended fertilizer and technology were available. Therefore, field experiments were conducted for 2 consecutive cropping seasons in Babile District, to investigate effects of applying mineral N and P fertilizer and vermicompost (VC) on seed yield and oil content of groundnut using an improved variety ‘BaHa-Gudo’. Treatments consisted of nitrogen (0,23 and 46 kg N/ha), phosphorus (0,46 and 92 kg P2O5/ha) and VC (0,2.5 and 5 t VC/ha). Results revealed that yield attributes, seed yield and seed oil content were significantly (p < 0.01) affected by fertilizers. Seed yield after combined application of 46 kg N, 46 kg P2O5 and 2.5 t VC/ha increased by about 113% compared to seed yield without any fertilizers. Enhancement in seed oil content at the aforementioned rate was 7.0%. It could, thus, be concluded that applying the aforementioned fertilizers would enable farmers to increase seed yield and oil content of groundnut for enhancing their income and livelihoods in the study area. | Getachew Bekele Nigussie Dechassa Tamado Tana J.J.Sharma | 2019 | Oil Crop Science2019，4，2： | 2 |
| 8 | 非洲主要国家竹种资源与利用显示文摘非洲是世界第3大竹资源分布区,竹资源量仅次于亚洲和拉丁美洲。东部非洲的埃塞俄比亚、肯尼亚等国家的竹种资源比较单一,以高地竹和低地竹为主;南部非洲的马达加斯加、中部非洲的喀麦隆和西部非洲的尼日利亚等国家竹种资源较为丰富。埃塞俄比亚、尼日利亚、喀麦隆、马达加斯加、刚果、莫桑比克、塞内加尔、加纳的竹林面积位居非洲前列。非洲竹资源加工利用主要以传统产品为主,现代加工水平不高,竹产品进出口水平有限。近年来,非洲主要竹资源分布国的竹产业战略与政策发展以及国际合作日渐活跃并取得积极进展。文章分析了非洲21个国家的竹资源及利用现状,以期为开发利用非洲竹资源提供参考。 | 李智勇 Wondimagegn Bekele Trinh Thang Long 吴君琦 郝颖 傅金和 李楠 王简 | 2020 | 世界竹藤通讯2020，18，5： | 2 |
| 9 | Genome-wide association mapping for grain shape and color traits in Ethiopian durum wheat(Triticum turgidum ssp.durum)显示文摘Grain shape and color strongly influence yield and quality of durumwheat.Identifying QTL for these traits is essential for transferring favorable alleles based on selection strategies and breeding objectives.In the present study,192 Ethiopian durum wheat accessions comprising 167 landraces and 25 cultivars were genotyped with a high-density Illumina iSelect 90K singlenucleotide polymorphism(SNP)wheat array to conduct a genome-wide association analysis for grain width(GW),grain length(GL),CIE(Commission Internationale l'Eclairage)L*(brightness),CIE a*(redness),and CIE b*(yellowness)traits.The accessions were planted at Sinana Agricultural Research Center,Ethiopia in the 2015/2016 cropping season in a complete randomized block design with three replications.Twenty homogeneous and healthy seeds per replicate were used for trait measurement.Digital image analysis of seeds with GrainScan software package was used to generate the phenotypic data.Analysis of variance revealed highly significant differences between accessions for all traits.Atotal of 46 quantitative trait loci(QTL)were identified for all traits across all chromosomes.One novelmajor candidate QTL(−lg P≥4)with pleiotropic effects for grain CIE L*(brightness)and CIE a*(redness)was identified on the long armof chromosome 2A.Eighteen nominal QTL(−lg P≥3)and 26 suggestive QTL(−lg P≥2.5)were identified.Pleiotropic QTL influencing both grain shape and color were identified. | Admas Alemu Tileye Feyissa Roberto Tuberosa Marco Maccaferri Giuseppe Sciara Tesfaye Letta Bekele Abeyo | 2020 | The Crop Journal2020，8，5： | 2 |
| 10 | Resource degradation and adoption of land conservation technologies in the Ethiopian Highlands: A case study in Andit Tid, North Shewa显示文摘 | Bekele Shiferaw Stein T. Holden | 1998 | Agricultural Economics1998，，3： | 2 |
| 11 | Petroleum migration pathways and charge concentration : A three dimensional model : Discussion 显示文摘 | Bekele E Person M Marsily G | 1999 | AAPG Bull1999，83，： | 1 |
| 12 | Prognostic significance of between-arm blood pressure differences显示文摘 | Agarwal R Bunaye Z Bekele DM | 2008 | Hypertension2008，51，3： | 1 |
| 13 | Self-assembling peptidomimetic monolayer nucleates oriented CdS nanocrystals显示文摘 | Bekele H Fendler JH Kelly JW | 1999 | J Am Chem Soc1999，121，： | 1 |
| 14 | Pelroleum migration pathways and charge conceration: A three dimensional model: Discussion显示文摘 | BEKELE E PERSON M MARSILY G | 1999 | AAPG Bulletin1999，83，： | 1 |
| 15 | Surgical jaundice a- mong Ethiopian inpatients in a university hospital显示文摘 | BEKELE M ERSUMQ T CHANIE W | 2013 | Ethiop Med J2013，51，4： | 1 |
| 16 | Regulation of lysophos-phatidate signaling by autotaxin and lipid phosphate phosphata-ses with respect to tumor progression, angiogenesis, metastasisand chemo-resistance显示文摘 | Samadi N Bekele R Capatos D | 2011 | Biochimie2011，93，1： | 1 |
| 17 | The metagenome of a biogas-producing microbial community of a production-scale biogas plant fermenter analysed by the 454-pyrosequencing technology 显示文摘 | Schltiter A Bekel T Diaz N N | 2008 | Journal of biotechnology2008，136，12： | 1 |
| 18 | Comparative and joint analysis of two metagenomic datasets from a biogas fermenter obtained by 454-pyrosequencing显示文摘 | Jaenicke S Ander C Bekel T | 2003 | PLoS One2003，6，14： | 1 |
| 19 | Multivariate analysis of morphological variation in sorghum (Sorghum bicolor (L.) Moench) germplasm from Ethiopia and Eritrea显示文摘 | Amsalu Ayana Endashaw Bekele | 1999 | Genetic Resources and Crop Evolution1999，，3： | 1 |
| 20 | High helminthic co-infection in tuberculosis patients with undernutritional status in northeastern Ethiopia显示文摘Background:Tuberculosis and parasitosis are the widely distributed diseases in Ethiopia with the leading cause of mortality and morbidity,respectively.There has been no information on the status of co-infections of tuberculosis and parasitosis in Oromia Zone of Amhara Region and South Wollo,Ethiopia.Hence,this study primarily focuses on determining the status of tuberculosis and parasitosis co-infections and associated factors.Methods:The study was conducted in Oromia Special Zone of the Amhara Regional State and South Wollo Zone,northeastern Ethiopia from April 2015 to January 2017.Tuberculosis cases confirmed by health personnel at the health institutions were the source of the study sample.In a cross-sectional study 384 smear positive pulmonary and extra-pulmonary tuberculosis cases were recruited.Faecal specimens provided by the study participants were examined for parasitic co-infections using direct saline microscopic test,Kato-Katz and concentration techniques.Nutritional status was determined using body mass index and mid-upper arm circumferences.Data were analyzed using descriptive statistical methods and Pearson chi-square.Results:Tuberculosis and parasitosis co-infection prevalence was 10.8%,and the proportion of intestinal helminths accounted for 9.7%while intestinal protozoa accounted for 1.9%.Cases with single parasitic infection was 89.3%among co-infected individuals.Co-infection of both disease was not significantly associated with gender and age(P>0.05).The prevalence of undernutrition was 58.6%as determined using body mass index and 73.0%as determined using mid-upper arm circumference with no significant association with gender.Among all forms of tuberculosis cases(384)screened for the study,the bacterial positivity was relatively more common in males(55.5%)than females(44.5%).Tuberculosis lymphadenitis was found to be the most prevalent(85.9%)form of extrapulmonary tuberculosis with cervical adenopathy(75.3%)being the commonly existing disease.Conclusions:The rate of helminthic co-infection is predominantly high than that of intestinal protozoa.Single parasitic co-infection was more common than double or multiple co-infections.Both body mass index and midupper arm circumference anthropometric parameters revealed greater risk of undernutrition in tuberculosis patients.Thus,screening and prompt treatment of parasites in tuberculosis patients and a support of nutritional supplementation for malnourished tuberculosis patients should be further studied which might enhance the disease treatment and minimize the risk of its complexity. | Fikru Gashaw Samuel Bekele Yalemtsehay Mekonnen Girmay Medhin Gobena Ameni Berhanu Erko | 2019 | Infectious Diseases of Poverty2019，8，5： | 1 |
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