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| 1 | RhB Adsorption Performance of Magnetic Adsorbent Fe_3O_4/RGO Composite and Its Regeneration through A Fenton-like Reaction显示文摘Adsorption is one of the most effective technologies in the treatment of colored matter containing wastewater. Graphene related composites display potential to be an effective adsorbent. However, the adsorption mechanism and their regeneration approach are still demanding more efforts. An effective magnetically separable absorbent, Fe3O4 and reduced graphene oxide(RGO) composite has been prepared by an in situ coprecipitation and reduction method. According to the characterizations of TEM, XRD, XPS, Raman spectra and BET analyses, Fe3O4 nanoparticles in sizes of 10-20 nm are well dispersed over the RGO nanosheets, resulting in a highest specific area of 296.2 m2/g. The rhodamine B adsorption mechanism on the composites was investigated by the adsorption kinetics and isotherms. The isotherms are fitting better by Langmuir model, and the adsorption kinetic rates depend much on the chemical components of RGO. Compared to active carbon, the composite shows 3.7 times higher adsorption capacity and thirty times faster adsorption rates. Furthermore,with Fe3O4 nanoparticles as the in situ catalysts, the adsorption performance of composites can be restored by carrying out a Fenton-like reaction, which could be a promising regeneration way for the adsorbents in the organic pollutant removal of wastewater. | Yalin Qin Mingce Long Beihui Tan Baoxue Zhou | 2014 | Nano-Micro Letters2014，6，2： | 11 |
| 2 | Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma显示文摘In our study, we determined the efficacy of bortezomib-based induction therapy followed by autologous stem cell transplant (ASCT) in newly diagnosed and relapsed/refractory (R/R) multiple myeloma (MM) patients and compared the advantages of early versus late transplant. We used a retrospective analysis to examine 62 patients, including 46 cases of newly diagnosed MM (early transplant group) and 16 cases of relapsed/refractory MM (late transplant group). All of these patients received bortezomib-based induction therapy followed by ASCT. The efficacy and side effects of the treatment regimen were analyzed. Patients' overall survival (OS) and progression-free survival (PFS) times were determined. The ratio of complete remission to near-complete remission (CR/nCR) was 69.5% versus 56.2% (P=0.361), respectively, for the early transplant group versus the late transplant group, respectively, after receiving bortezomib-based induction therapy; the overall response rates of the two group were 91.3% and 81.2%, respectively (P=0.369). After receiving ASCT, the CR/nCR of the two groups increased to 84.8% and 81.3%, respectively. The median time required for neutrophil engraftment of the early transplant group and the late transplant group was 11 and 14.5 days, respectively (P=0.003); the median time required for platelet engraftment was 13 and 21.5 days (P=0.031), respectively. There were no significant differences in the toxic side effects observed during induction therapy and ASCT between the two groups. The OS of the two groups was not statistically different (P=0.058). The PFS of the early transplant group and the late transplant group was 41.6 and 26.5 months, respectively (P=0.008). Multivariate analysis demonstrated that the time of receiving ASCT, the types of M protein, and the International Staging System (ISS) stage were all independent factors that influenced PFS. In conclusion, patients in a suitable condition for ASCT should be recommended to have an early ASCT immediately after diagnosis. | Junru Liu Juan Li Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Chinese Journal of Cancer Research2013，25，2： | 4 |
| 3 | Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer显示文摘MicroRNAs (miRNAs ) 是小非编码的 RNA 分子的一个类(包含 22 核苷酸) ,它在 RNA silencing 和基因表示的 post-transcriptional 规定工作[1 ] 。miRNAs 被报导了在 tumorigenesis 起一个关键作用[1 ] 。在 miRNA 基因的一些单个核苷酸多型性(SNP ) 能影响 miRNAs 的产生或功能,并且可能从而影响肿瘤生长和开发。 | Xiaoyan Liu Beihui Xu Shujin Li Bin Zhang Peimin Mao Beibei Qian Lin Guo Peihua Ni | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 2 |
| 4 | High prevalence of hepatitis B virus infection in multiple myeloma显示文摘 | Beihui Huang Juan Li Zhenhai Zhou Dong Zheng Junru Liu Mei Chen | 2012 | Leukemia & Lymphoma2012，，： | 2 |
| 5 | Everolimus enhances the cytotoxicity of bendamustine in multiple myeloma cells through a network of pro-apoptotic and cell-cycle-progression regulatory proteins显示文摘Bendamustine 是有在治疗的一些功效的一个 bifunctional alkylating 代理人最新诊断了并且 relapsed/refractorymultiple 骨髓瘤(公里) 。Everolimus, rapamycin (mTOR ) 的一个哺乳动物的目标禁止者,是在许多癌症有功效的另外的答应 chemotherapeuticagent。我们调查了个人和 combinational 在公里房间线(RPMI8226 和 MM1.S ) 和主要公里房间的 thesedrugs 的细胞毒素的效果。我们的结果表明了这些药的 synergistic 效果,它为 p53-wild-type 和 p-53-deleted 公里房间是有效的,但是在从 healthydonor 的 mononuclear 房间是最小的。有二个代理人的联合治疗禁止了增长并且作为 assessedby Annexin-V/PI 染色, caspase-3 降级,和 PARP 劈开支持了 cytotoxicity 和 apoptosis。房间死亡与 thepro-apoptotic 蛋白质 Bax 的起来规定和 anti-apoptotic 蛋白质 Mcl-1 和 survivin 的下面规定被联系。联合 drugtreatment 也在 mTOR 的下游的目标蛋白质的层次支持了减少小径, p70s6k,和 4EBP-1,以及在 MM1.S 房间的肿瘤 suppressor 蛋白质 p53 的 phosphorylation 的水平的增加。p21 也是有二药的 down-regulatedupon 治疗,建议通过房间周期拘捕的版本的促进感受性的机制。我们的 resultsdemonstrate 可以贡献 everolimus 和 bendamustine 的 synergistic cytotoxicity,并且为公里的组合处理为申请向一个基本原理提供 alkylating 代理人和 mTOR 禁止者 infuture 的规章的因素的一个网络临床的实践。 | Bo Lu Juan Li Jingxuan Pan Beihui Huang Junru Liu Dong Zheng | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 1 |
| 6 | Hepatitis B virus reactivation in patients with multiple myeloma receiving bortezomib-containing regimens followed by autologous stem cell transplant显示文摘 | Juan Li Beihui Huang Ying Li Dong Zheng Zhenhai Zhou Junru Liu | 2015 | Leukemia & Lymphoma2015，，6： | 1 |
| 7 | New Solid-state Fermentation Process for Repeated Batch Production of Fibrtnolytic Enzyme by Fusarium oxysporum显示文摘 | Su Tao Liu Beihui Li Peng | 1998 | Proc Biochem1998，33，4： | 1 |
| 8 | Hepatitis B virus infection status is an independent risk factor for multiple myeloma patients after autologous hematopoietic stem cell transplantation显示文摘 | Juan Li Junru Liu Beihui Huang Dong Zheng Mei Chen Zhenhai Zhou Duorong Xu Waiyi Zou | 2013 | Tumor Biology2013，，3： | 1 |
| 9 | Effects of air pressure amplitude on cellulase productivity by Trichoderma viride SL-1 in periodic pressure solid state fermenter 显示文摘 | SUN TAO LIU BEIHUI LI ZUOHU | 1999 | Process Biochemistry1999，，34： | 1 |
| 10 | Soluble Fms-like Tyrosine Kinase-1 Expression Inhibits the Growth of Multiple Myeloma in Nude Mice显示文摘Angiogenesis 包括多重骨髓瘤(公里) 是在生长和前进 ofhematological 恶意的一个必要因素。脉管的 endothelial 生长因素和它的受体被显示了是为治疗肿瘤的目标。这研究探索效果在裸体老鼠的公里房间线 KM3 的生长上的可溶的脉管的 endothelial 生长因素受体 Fms-liketyrosine kinase-1 (sFLT-1 ) 的调停 ofadenovirus 的交货。sFLT-1 cDNA 被反向的抄写聚合酶链反应从人的脐的静脉 endothelial 房间放大并且被用作 transgene 构造带 sFLT-1 (ADV-sFLT ) 的 adenoviral 向量。Cellproliferation 和 3-[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物试金被执行在人的脐的静脉 endothelial 房间和 KM3 房间 invitro 上评估 ADV-sFLT 的效果。十八只女 BALB/c 裸体老鼠与 KM3 房间皮下地被接种,并且他们随机被划分成三个组并且与 ADV-sFLT 静脉内地注射了, ADV-LacZ,缓冲 orphosphate 盐(PBS ) 。KM3 异种皮移植的体积一个星期被测量两次。在起始的处理,在与 ADV-sFLT 对待的鼠标的公里异种皮移植的卷, ADV-LacZ,或 PBS 以后的三个星期是 770.32 ± 2 8.73 mm^3, 1983.36 ± 4 3.72 mm^3,和 2042.05 ± 8 2.31 mm^3,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。微容器密度的价值在与 ADV-sFLT, ADV-LacZ,和 PBS 治疗的肿瘤是 29.17 ± 6 .85,79.17 ± 7 .35,和 78.83 ± 8 .54,分别地(P<0.01, ADV-sFLT 对 ADV-LacZ 或 PBS ) 。这研究建议调停侵入人体气管粘膜的病菌的 sFLT-1gene 极大地禁止在老鼠异种皮移植的生长和 angiogenesis,和力量为公里作为新治疗服务的导出公里的肿瘤。 | Junru LIU Juan LI Chang SU Beihui HUANG Shaokai LUO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 1 |
| 11 | Effect of elevated temperature on Trichodermaviride SL-1 in solid state fermentations显示文摘 | Sun Tao Liu Beihui Li Zuohu | 1997 | Biotech Lett1997，19，2： | 1 |
| 12 | New solidstate fermentation process for repeated batch production of fibrinolytic enzyme by Fusarium oxysporum 显示文摘 | TAO S BEIHUI L PENG L | 1998 | Process Biochem1998，33，： | 1 |
| 13 | Successive cultivation of Fusarium oxysporum on rice chaff for economic production of fibrinolytic enzyme显示文摘 | S. Tao L. Peng L. Beihui L. Deming L. Zuohu | 1998 | Bioprocess Engineering1998，，5： | 1 |
| 14 | Solid state fermentation of rice chaff for fibrinolytic enzyme production by Fusarium oxysporum显示文摘 | Sun Tao Li Peng Liu Beihui Liu Deming Li Zuohu | 1997 | Biotechnology Letters1997，，5： | 1 |
| 15 | Anterior Myocardial Territory May Replace the Heart as Organ at Risk in Intensity-Modulated Radiotherapy for Left-Sided Breast Cancer显示文摘 | Wenyong Tan Dong Liu Chenbin Xue Jiaozhen Xu Beihui Li Zhengwang Chen Desheng Hu Xionghong Wang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 16 | Chronic depression of hypothalamic paraventricular neuronal activity produces sustained hypotension in hypertensive rats显示文摘 | Vera Geraldes Nataniel Goncalves-Rosa Beihui Liu | 2014 | Exp Physiol2014，99，4： | 1 |
| 17 | Anterior Myocardial Territory May Replace the Heart as Organ at Risk in Intensity-Modulated Radiotherapy for Left-Sided Breast Cancer显示文摘 | Wenyong Tan Dong Liu Chenbin Xue Jiaozhen Xu Beihui Li Zhengwang Chen Desheng Hu Xionghong Wang | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 18 | Enhanced cellulase production in fed-batch solid state fermentation of Trichoderma viride SL-1显示文摘 | Tao S Beihui L Zuohu L | 1997 | Chem Tech Biotechnol1997，69，： | 1 |
| 19 | The fourth transmembrane helix is important for DRAM function显示文摘调整损坏的 autophagy 调节的人基因(DRAM ) 被 Crighton 等首先识别。在 2006 当他们在感应、分析的 p53 以后与 doxycycline 和 adriamycin 对待 Saos-2 房间时由使用 microarray 技术的基因表示[1 ] 。DRAM 基因在人的 chromosomal 12q23.2 上定位[2 ] 并且编码谁的 238 氨基酸 lysosomal 蛋白质在 autophagy 的角色种系发生地被保存。作为 P53 的一个直接目标, DRAM 是在导致 p53 的 autophagy 的一个批评调节的人并且编程序房间死亡[3 ] 。不过, DRAM 通过调制 autophagy 的准确机制没被澄清。顺序分析预言 DRAM 蛋白质包含六个 transmembrane 领域和几个另外的高度交谈的领域[1 ] ,因此在 autophagy 理解 DRAM 的每个领域的准确角色可以帮助澄清准确机制。得到 DRAM 和它的不同 transmembrane 域的函数的初步的理解,我们构造了 DRAM 的真核细胞的表达式 plasmids , pEGFP-DRAM 并且包括 pEGFP-DN1 ,它的 deletants ,根据预言的 pEGFP-DN2-3 , pEGFP-DN4-5 , pEGFP-DN4 , pEGFP-DN5 ,和 pEGFP-DN6 结果[ 1 ](图 1A ),并且 transfected 他们进 HepG2 房间。空向量 pEGFP-N1 被用作否定控制。mRNA | Beihui Xu Jiemin Wu Xianfan Liu Hong Xu Peihua Ni | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 1 |
| 20 | New Solid- state Fermentation Process for Repeated Batch Production of Fibrtnolytic Enzyme by Fusarium oxysporum显示文摘 | Su Tao Liu Beihui Li Peng | 1998 | Proc Biochem1998，33，4： | 1 |
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