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| 1 | Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?显示文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement. | Mohammadreza Abdollahi Neda Khalilian Ekrami Morteza Ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh | 2020 | World Journal of Gastroenterology2020，26，38： | 5 |
| 2 | A numerical optimizationtechnique for desi^i of wheel profiles显示文摘 | JAHED H BEHROOZ F MOHAMMAD A | 2008 | Wear2008，264，12： | 1 |
| 3 | A modified methodology in electricity tracing problems based on Bialek's method显示文摘 | Mahmood N Seyed H H Behrooz V | 2014 | Electrical Power and Energy Systems2014，，60： | 1 |
| 4 | Comparison of inter- trochanteric fracture fixation with dynamic hip screw and bipolar hemiarthroplasty techniques 显示文摘 | Mohamad E Alireza M Behrooz H | 2013 | Arch Bone Jt Surg2013，1，1： | 1 |
| 5 | Characterization of essential oil com- ponents of Iranian geranium oil using gas chromatography-mass spectrome- try combined with chemometrie resolution techniques 显示文摘 | Mehdi J H Behrooz Z Hassan S | 2006 | Journal of Chroma- tography A2006，1114，： | 1 |
| 6 | Fault detection and iden- tification for voltage sag state estimation in power systems 显示文摘 | JAMAL B HOSSEIN H S BEHROOZ V | 2010 | Turkish Journal of Electrical Engineering and Computer Sciences2010，18，4： | 1 |
| 7 | Combined heat and power economic dispatch by mesh adaptive direct search algorithm显示文摘 | SADAT HOSSEINI S S JAFARNEJAD A BEHROOZ A H | 2011 | Expert Systems with Applications2011，38，6： | 1 |
| 8 | Tool path accuracy enhancement through geometrical error compensation 显示文摘 | Mehrdad V N Mohsen H Behrooz A | 2011 | International Journal of Machine Tools and Manufacture2011，51，6： | 1 |
| 9 | Articular cartilage changes in experimental osteoarthritis in rabbits: MRI and morphological findings 显示文摘 | MOHAMMAD H B SEIFOLLAH D N BEHROOZ N | 2011 | Comp Clin Pathol2011，20，： | 1 |
| 10 | Characterization of essential oil components of Iranian geranium oil using gas chromatography mass spectrometry combined with chemometric resolution techniques显示文摘 | MEHDI J H BEHROOZ Z HASSAN S | 2006 | Chromatogr A2006，1114，： | 1 |
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