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| 1 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 2 | Common bile duct stenosis in complicated chronic pancreatitis 显示文摘 | Schlosser W Siech M Beger G | 2001 | Scand J Gastroenterol2001，36，2： | 1 |
| 3 | Biliary and gastric bypass or stenting in nonresectable periampullary cancer: analysis on the basis of controlled trials 显示文摘 | Schwarz A Beger H G | 2000 | Int J Pancreatol2000，27，1： | 1 |
| 4 | The Economics of Small Business Finance:the Role of Private Equity and Debt Market in the Financial Growth Cycle显示文摘 | Beger A N Udell G F | 1998 | Journal of Ranking and Finance1998，，22： | 1 |
| 5 | Gallbladder carcinoma and surgical treatment显示文摘 | Korth H Beger G | 2000 | Langgenbeck''s Arch Surg2000，385，： | 1 |
| 6 | Frequency and time course of pancreatis and extrapancreatic bacterial infection in experimental acute pancreatitis in rats显示文摘 | Schwarz M Thomsen J Meyer H Buchler M W Beger H G | 2000 | Surgery2000，127，： | 1 |
| 7 | Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of isoflavonoid daidzein显示文摘 | Hut H G Beger R D Heinze T M | 2002 | Arch Micro- biology2002，178，： | 1 |
| 8 | Combined PET/CT imaging: first clinical experience at University of Essen 显示文摘 | Frendenry LS Antock G Beger A | 2003 | Hosp Radiol2003，3，1： | 1 |
| 9 | Prevention of sever change in acute:prediction and prevention显示文摘 | Beger H G Rau B Isenmann R | 2001 | J Hepatobiliary Pancreat Surg2001，8，： | 1 |
| 10 | Natural course of acute pancreatitis显示文摘 | BEGER H G RAU B MAYER J | 1997 | World J Surg1997，21，2： | 1 |
| 11 | A randomized double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis显示文摘 | BUCHLER M W MALFERTHEINER P BEGER H G | 1999 | Gut1999，45，： | 1 |
| 12 | Combined PET/CT Imaging:First clinical experience at University of Essen显示文摘 | Frendenry LS Antock G Beger A | 2003 | Hospital Radiology2003，3，1： | 1 |
| 13 | ComParison of jogging, the relaxation respon, and group interaction for stress reduction显示文摘 | Beger B G Friedmann E Eaton M | 1988 | Joumal of Exercise Psyehology1988，，10： | 1 |
| 14 | Natural course of acute pancreatitis 显示文摘 | Beger H G Rau B Mayer J | 1997 | World J Surg1997，21，2： | 1 |
| 15 | Early seizures following intracerebral hemorrhage : implications for therapy显示文摘 | Beger AR Liprln RB Jantos G | 1998 | Neurology1998，38，： | 1 |
| 16 | Roleofoctreotide in the treatmento fpancreatic cancer显示文摘 | Ebert M Friess H Beger H G | 1995 | Digestion1995，55，1： | 1 |
| 17 | Isolation of human intes- tinal bacteria metabolizing the natural isoflavone glycosides daid- zin and genistin 显示文摘 | Hur H G Lay J 0 Jr Beger R D | 2000 | Arch Microbiol2000，174，6： | 1 |
| 18 | Natural history of necrotizing pancreatitis显示文摘 | BEGER H G RAU B ISENMANN R | 2003 | Pancreatology2003，3，2： | 1 |
| 19 | Isolation of an anaero- bic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein 显示文摘 | Hur H G Beger R D Heinze T M | 2002 | Arch Microbiol2002，178，1： | 1 |
| 20 | Copyright law in the European Union,with special reference to Germany显示文摘 | BEGER G | 2006 | Library Review2006，54，2： | 1 |
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