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| 1 | Successful photodynamic therapy for biliary papillomatosis:A case report显示文摘Papillomatosis of the bile duct is a rare disease with a high risk of malignant transformation. Therapeutical options include partial hepatectomy and liver transplantation. A previously healthy 65-years old male developed jaundice and right upper abdominal quadrant pain in 1996. A villous adenoma of the distal bile duct was diagnosed. A Whipple procedure was performed. In 2002 the patient turned symptomatic again. Another adenoma was found in the right hepatic duct resulting in a right hepatectomy. Two years later the patient again developed cholestasis. After drainage of the left hepatic duct with a percutaneous transhepatic cholangial drainage (PTCD) catheter, a recurrent biliary adenomatosis was diagnosed by cholangioscopy. As there was no surgical option left, the patient received photodynamic therapy (PDT) for the recurrent biliary papillomatosis. Three mo after he received further photodynamic therapies, the bile duct epithelium appeared normal and the patient had no signs of adenomatosis, both macroscopically and histologically. The follow-up cholangioscopy in late 2005 revealed only a small papilloma without the need for intervention. In early 2006, the patient died of multi organ failure without signs of extrahepatic cholestasis or cholangitis at the age of 75, 10 years after the diagnosis of biliary papillomatosis was established. The patient exceeded the average life expectancy of patients with biliary papillomatosis by far. Thus, PDT might be a sufficient therapeutic option for recurrent papillomatosis patients with no significant side effects. | Lars P Bechmann Philip Hilgard Andrea Frilling Brigitte Schumacher Hideo A Baba Guido Gerken Thomas Zoepf | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 2 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 3 | Storage media and temperature maintain normal anatomy of cadaveric human skin for transplantation to full-thickness skin wounds显示文摘 | Robb E C Bechmann N Plessinger R T | 2001 | J Burn Care Rehabil2001，22，6： | 2 |
| 4 | Freeze-thaw effects on phosphorus loss in runoff from manured and catch-cropped soils 显示文摘 | BECHMANN M E KLEINMAN P J A SHARPLEY A N | 2005 | Journal of Environmental Quality2005，34，： | 1 |
| 5 | Free fatty acids repress small heterodimer partner (SHP) activa- tion and adiponectin counteracts bile acid -induced liver inju- ry in superobese patients with nonalcoholic steatohepatitis 显示文摘 | BECHMANN LP KOCABAYOGLU P SOWA JP | 2013 | Hepatology2013，57，4： | 1 |
| 6 | A rarecase of propofol-induced acute liver failure and literature re- view显示文摘 | Kneiseler G Bachmann HS Bechmann LP | 2010 | Case Rep Gastroenterol2010，4，1： | 1 |
| 7 | Onset of heart failure determines the hepatic cell death pattern 显示文摘 | Herzer K Kneiseler G Bechmann LP | 2011 | Ann Hepatol2011，10，2： | 1 |
| 8 | Current concepts in neuroanatomical tracing显示文摘 | Kobbert C Apps R Bechmann I | 2000 | Prog Neurobiol2000，62，4： | 1 |
| 9 | Integrated tool for risk assessment in agricultural management of soil erosion and los- ses of phosphorus and nitrogen显示文摘 | Bechmann M Stnacke P Kvm S | 2009 | Science of the Total Environ- ment2009，407，2： | 1 |
| 10 | Nitrogen balances and leaching in four agricultural catchments in southeastern Norway显示文摘 | BECHMANN M EGGESTAD H O VAGSTAD N | 1998 | Environmental Pollution1998，102，1： | 1 |
| 11 | Continuous free form deformation显示文摘 | Bechmann D Bertrand Y Ther S | 1997 | Computer Networks and ISDN System1997，29，14： | 1 |
| 12 | Integrated tool for risk assessment in agricultural management of soil erosion and losses of phosphorus and nitrogen 显示文摘 | Bechmann M Stalnacke P Kvaern S | 2009 | Science of the Total Environment2009，407，2： | 1 |
| 13 | A plasma mem- brane zinc transporter from Medicago truncatula is up-regulated in roots by Zn fertilization, yet down-regulated by arbuscular mycorrhizal colonization 显示文摘 | Burleigh SH Kristensen BK Bechmann IE | 2003 | Plant Mol Biol2003，52，5： | 1 |
| 14 | Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia显示文摘 | Rami A Bechmann I Stehle J H | 2008 | Prog Neurobiol2008，85，3： | 1 |
| 15 | Effect of the Endocrine Disrupter Nonylphenol on the Marine Copepod Tisbe Battagliai 显示文摘 | BECHMANN R K | 1999 | Science of the Total Environment1999，233，13： | 1 |
| 16 | Testing the Norwegian phosphorus index at the field and subcatchment scale 显示文摘 | Bechmann M Stalnacke P Kvaern S | 2007 | Agriculture Ecosystems and Environment2007，120，24： | 1 |
| 17 | Plant nutrient transporter regulation in arbuscular myeorrhizas 显示文摘 | Burleigh S H Bechmann I E | 2002 | Plant and Soil2002，244，： | 1 |
| 18 | The Differences Between Stock Splits and Stock Dividends:Evidence on the Retained Earnings Hypothesis显示文摘 | BECHMANN K L RAABALLE J | | 0，，34： | 1 |
| 19 | Effect of initial stress on in Vibrating quartz plates显示文摘 | Ballato A D Bechmann R | 1960 | Proceedings of IRE1960，48，2： | 1 |
| 20 | Imaging of pos-terior chamber phakic intraocular lens by optical coher-ence tomogrphy 显示文摘 | Bechmann M Ullrich S Thiel M J | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
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