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| 1 | NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling显示文摘The NLRP3-IL-1β pathway plays an important role in adipose tissue(AT)-induced inflammation and the development of obesityassociated comorbidities.We aimed to determine the impact of NLRP3 on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and extracellular matrix(ECM)remodeling.Samples obtained from 98 subjects were used in a case-control study.The expression of different components of the inflammasome as well as their main effectors and inflammation-and ECM remodeling-related genes were analyzed.The impact of blocking NLRP3 using siRNA in lipopolysaccharide(LPS)-mediated inflammation and ECM remodeling signaling pathways was evaluated.We demonstrated that obesity(P<0.01),obesity-associated T2D(P<0.01)and NAFLD(P<0.05)increased the expression of different com ponents of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.We also found that obese patients with T2D exhibited increased(P<0.05)hepatic gene expression levels of NLRP3,IL1B and IL18.We showed that NLRP3,but not NLRP1,is regulated by inflammation and hypoxia in visceral adipocytes.We revealed that the inhibition of NLRP3 in human visceral adipocytes significantly blocked(P<0.01)LPS-induced inflammation by downregulating the mRNA levels of CCL2,IL1B,IL6,IL8,S100A8,S100A9,TLR4 and TNF as well as inhibiting(P<0.01)the secretion of IL1-β into the culture medium.Furthermore,blocking NLRP3 attenuated(P<0.01)the LPS-induced expression of important molecules involved in AT fibrosis(COL1A1,COL4A3,COL6A3 and MMP2).These novel findings provide evidence that blocking the expression of NLRP3 reduces AT inflammation with significant fibrosis attenuation. | Xabier Unamuno Javier Gomez-Ambrosi Beatriz Ramirez Amaia Rodriguez Sara Becerril Victor Valenti Rafael Moncada Camilo Silva Javier Salvador Gema Fruhbeck Victoria Catalan | 2021 | Cellular & Molecular Immunology2021，18，4： | 9 |
| 2 | HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration显示文摘研究是否特定的等位基因 HLA 一级(HLA -- A 和 HLA-B ) 并且班 II (HLA 医生) 是风险因素因为年龄的 exudative 类型的发展联系了有斑点的退化(ARMD ) , HLA 抗原与 ARMD 在正常、影响的眼睛两个都被表示。我们设计了未来的控制盒子的研究。我们与主要经典或秘密的 choroidal neovascularization 招募了 75 个病人,对 ARMD 第二等,并且与光力学的治疗对待。超过 55 岁的 250 个病人,没有 ophthalmologic 病理,为分析平淡的检查去了医院的人,被用作控制。数据的分析显示出二个组之间的重要差别。等位基因 HLA-B27 与 ARMD 断然相关(p < 0.0113 ) 。然而,我们没发现等位基因否定地联系了。因此 HLA-B27 是等位基因预先安排承受 ARMD。 | Enrique Villegas Becerril Rafael Gonzalez Fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera | 2009 | Cellular & Molecular Immunology2009，6，4： | 2 |
| 3 | Organic solar cells with solution-processed graphene transparent electrodes显示文摘 | Wu Junbo Hector A Becerril Bao Zhenan | 2008 | Appl Phys Lett2008，92，26： | 1 |
| 4 | Evaluation of solution-processed reduced graphene oxide films as transparent conductors显示文摘 | Becerril H A Mao J Liu Z | 2008 | ACS Nano2008，2，3： | 1 |
| 5 | Newinsights on glyphosate mode of action in nodularmetabolism:role of shikimate accumulation 显示文摘 | De Maria N Becerril J M Garcia-Plazaola J I | 2006 | Journalof Agricultural and Food Chemistry2006，54，7： | 1 |
| 6 | Selection of tumor-specific internalizing human antibodies from phage libraries显示文摘 | Poul MA Becerril B Nielsen UB | 2000 | J Mol Biol2000，301，5： | 1 |
| 7 | Organic light-emitting diodes on solution-processed graphene transparent electrodes显示文摘 | Wu J Agrawal M Becerril H A | 2010 | ACS Nano2010，4，1： | 1 |
| 8 | Syn- thesis of low molecular weight thiols in response to Cd exposure in Thlaspi caerulescens 显示文摘 | Hernandez-Allica J Garbisu C Becerril J M | 2006 | Plant Cell Environ- ment2006，29，7： | 1 |
| 9 | Effects of Cd vacancies on the electrical properties of polycrystalline CdTe sputtered films显示文摘 | Becerril M Zelaya--Angel O Ramo Arez--Bon R | 2001 | Journal of Physics and Chemistry of Solids2001，62，： | 1 |
| 10 | Emotional-stimulus processing in trait anxiety is modulated by stimulus valence during neuroimaging of a working-memory task显示文摘 | Fales C.L Becerril K.E Luking K.R Barch D.M | | 0，，02： | 1 |
| 11 | Phytostabilization of Metal Contaminated Soils显示文摘 | I. Alkorta J.M. Becerril C. Garbisu | 2010 | Reviews on Environmental Health2010，，2： | 1 |
| 12 | Effects of glyphosate on rhizosphere soil microbial communities under two different plant compositions by cultivation-dependent and-independent methodologies 显示文摘 | Mijangos I Becerril J M Albizu I | 2009 | Soil Biology and Biochemistry2009，41，3： | 1 |
| 13 | Epitopes recognized by hu- man T lymphocytes in the Rop2 Protein antigen of Toxoplasma tondii 显示文摘 | Saadvedra R Becerril MA Dubeau XC | 2001 | Parasitol Res2001，87，1： | 1 |
| 14 | Possible role in migration and homing 显示文摘 | Gareia-de-Alba C Becerril C Ruiz V et ah Expression of matrix metalloproteases by fibroeytes | 2010 | Am J Respir Crit Care Med2010，182，： | 1 |
| 15 | Chemical Stabilization of Metal-Contaminated Mine Soil: Early Short-Term Soil-Amendment Interactions and Their Effects on Biological and Chemical Parameters显示文摘 | M. A. Galende J. M. Becerril M. T. Gómez-Sagasti O. Barrutia L. Epelde C. Garbisu A. Hernández | 2014 | Water, Air, & Soil Pollution2014，，2： | 1 |
| 16 | BAT: a new target for human obesity? 显示文摘 | Fruhbeck G Becerril S Sainz N | 2009 | Trends Pharmacol Sci2009，30，8： | 1 |
| 17 | Organic light-emitting diodes on solution-processed graphene transparent electrodes显示文摘 | Wu J Agrawal M Becerril H A | 2009 | ACS Nano2009，4，1： | 1 |
| 18 | In vitro assessment of DNA damage after short-and long-term exposure to benzo(a)pyrene using RAPD and the RTG-2 fish cell line显示文摘 | Castao A Becerril C | 2004 | Mutation Research2004，552，12： | 1 |
| 19 | Effects of dietary arginine on hematological parameters and innate immune function of channel catfish 显示文摘 | BUENTELLO J A REYES - BECERRIL M ROMERO - GERALDO MDE J | 2007 | J Aquat Anim Health2007，19，3： | 1 |
| 20 | New insights on glyphosate mode of action in nodular metabolism: Role of shikimate accumula- tion 显示文摘 | De Maria N Becerril J M Garcla-Plazaola J I | 2006 | Journal of Agricultural and Food Chem- istry2006，54，： | 1 |
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