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| 1 | Circular noncoding RNAs as potential therapies and circulating biomarkers for cardiovascular diseases显示文摘在染色体宽的分析和定序 RNA 技术的最近的前进导致了小 noncoding RNA 的发现,例如 microRNAs (米尔) ,以及两线性长 noncoding RNA (lncRNAs ) 和圆形的长 noncoding RNA (circRNAs ) 。在心血管的疾病(CVD ) 的治疗,预后和诊断的米尔和 lncRNAs 的重要性广泛地被报导了。我们以前也为 CVD 在治疗并且作为 biomarkers 考察了他们的含意。更最近, circRNAs 也在 CVD 作为重要管理者出现了。CircRNAs 是被背送信人前 RNA (pre-mRNAs ) 的特定的区域拼接产生的圆形的染色体产品。对 circRNAs 的成长兴趣导致了他们的 pathophysiological 功能的一个宽数组的发现。CircRNAs 被显示了是象心肌的梗塞,动脉粥样硬化,心肌症和心脏的纤维变性那样的 CVD 的关键管理者。因此, circRNAs 最近为 CVD 作为潜在的治疗学的目标和 biomarkers 被建议了。在这评论,我们在 circRNAs 上总结文学的当前的状态,以他们的生物的续生说和行动的全球机制开始。我们然后在各种各样的 CVD 提供他们的参与的一个提要。最后,我们为 CVD 的早察觉作为 biomarkers 强调 circRNAs 的大潜力,并且讨论作为有希望的 biomarkers 加亮 circRNAs 的利用的几项专利和最近的报纸。 | Ahmed S BAYOUMI Tatsuya AONUMA Jian-peng TEOH Yao-liang TANG II-man KIM | 2018 | Acta Pharmacologica Sinica2018，39，7： | 16 |
| 2 | 成人突发性耳聋突发性耳聋:是否采用高压氧疗法需要达成共识显示文摘突发性耳聋的自愈率只有39%,其患者需要接受相应的治疗1.Fishman和Cullen所著的突发性耳聋治疗方法的文章中未提及高压氧治疗2。Cochrane系统评价发现高压氧疗法与类固醇疗法相比,疗效更为显著。Cochrane系统评价指出,“由于采用此疗法的患者人数较少,高压氧疗法尚不成熟完善,且相关的文献报道较少,应对其疗效的可靠性持怀疑态度。” | J Alexander Ahmed B Bayoumy 李谨(译) 张罗(校) | 2019 | 英国医学杂志中文版2019，22，5： | 4 |
| 3 | Association of gene variants with susceptibility to type 2 diabetes among Omanis显示文摘AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among Omanis.METHODS:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,Oman.Adult control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical checkup.The difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this study.Almost all volunteers questioned had a relativewith diabetes mellitus.Inspite of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%power.Data was collected from June 2010 to February 2012.RESULTS:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),P<0.001],[TCF7L2(rs7903146),P<0.001],[CDKAL1(rs10946398),P<0.05],[CDKN2A/B(rs10811661),P<0.05]}.The highest genotype variation%between diabetics and controls was found at KCNJ11(2.07%)and TCF7L2(1.62%).This study was not able to detect an association of T2D risk with gene variants of IGF2BP2(rs4402960),SLC30A8(rs13266634),CAPN10(rs3792267)and HHEX(rs1111875).Moreover,no association was found between FTO gene variants(rs9939609 and rs8050136)and T2D risk.However,T2D risk was found to be significantly associated with obesity(P=0.002,OR=2.22);and with the Waist-to-Hip ratio(n=532,P=1.9×10^(-7),OR=2.4),[among males(n=234,P=1.2×10^(-4),OR=2.0)and females(n=298,P=0.001,OR=6.3)].CONCLUSION:Results confirmed the association of KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398)and CDKN2A/B(rs10811661)gene variants with susceptibility to T2D among Omani Arabs. | Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan Deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi | 2015 | World Journal of Diabetes2015，6，2： | 3 |
| 4 | Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation显示文摘早泄(PE ) 是最普通的性混乱。它影响 20 % -30%成年的人;这个条件的原因论还没被阐明了。这研究的目的是为 PE 的处理在不同剂量评估有性交的功效,安全, tolerability,不受欢迎的效果和对 tramadol hydrochloride 的改进满足。介绍了与的 300 个病人的一个总数终生(主要) PE 在这研究被包括。学习被执行 28 个星期,安慰剂(淀粉药片) 在被给 4 个星期,并且活跃成分(tramadol hydrochloride ) 在不同治疗学的剂量被管理 24 个星期。病人们被划分成三个相等的组,每由 100 个病人组成。第一组(A) 被给 tramadol hydrochloride 囊 25 mg。第二组(B) 被给 tramadol hydrochloride 囊 50 mg。第三组(C) 被给 tramadol hydrochloride 囊 100 mg。所有自愿地包括的 300 个参加者完成了学习。病人的年龄从 25 ~ 50 年变化了。在治疗经期以后,记录数据为每个组被收集并且分析。结果在在所有的射精的潜伏时间(IELT ) 与基线数据相比组织的吝啬的 intravaginal 显示出高度重要的增加(P< 0.0001 ) 。我们断定在对 PE 的治疗的需求上的不同剂量的那使用的 tramadol hydrochloride 有效、安全、可容忍,与最小的不受欢迎的效果,并且为这个指示的赞同应该被寻求。 | Bayoumy I Eassa Mohamed A EI-Shazly | 2013 | Asian Journal of Andrology2013，15，1： | 2 |
| 5 | Low Complexity Decimation Filters for Multi-standard Digital Receivers显示文摘 | Xihuitl J Kumar A Bayoumi M | 2005 | IEEE International Symposium on Circuits and Systems2005，4，1： | 1 |
| 6 | Estimating Trade Equations from Aggregate Bilateral Data 显示文摘 | Bayoumi T | 1999 | IMF Working Paper WP/99/741999，，： | 1 |
| 7 | The potential palliative role and possible immune modulatory effects of low-dose total body irradiation in relapsed or chemo-resis- tant non-Hodgkin's lymphoma显示文摘 | Safwat A Bayoumy Y E1-Sharkawy N | 2003 | Radiother Oncol2003，69，1： | 1 |
| 8 | Ever Closer to Heaven? An Optimum-Currency-Area Index for European Countries显示文摘 | Bayoumi Tamim and Barry Eichengreen | 1997 | European Economic Review1997，，41： | 1 |
| 9 | Clinical charac- teristics and risk factors of pulmonary embolism 显示文摘 | Algahtani F H Bayoumi N Abdelgadir A | 2013 | J Thromb Haemos2013，11，2： | 1 |
| 10 | Differential he- modynamic response to repetitive transcranial magnetic stimu- lation in acute stroke patients with cortical versus subcorti- cal infarcts显示文摘 | Khaleel SH Bayoumy IM E1-Nabil LM | 2010 | Eur Neurol2010，63，6： | 1 |
| 11 | Effect of LiAIO2 nanoparficle filler concentration on the electrical properties of PEO-LiCIO4 composite 显示文摘 | Masoud E M EI-Bellihi A -A Bayoumy W A | 2013 | Materials Research Bulletin2013，48，3： | 1 |
| 12 | Invariant 2D object recognition using the wavelet modulus maxima 显示文摘 | Khalil M I Bayoumi M M | 2000 | Pattern Recognition Letters2000，21，8： | 1 |
| 13 | Modulation of doxorubicin cytotoxicity by resveratrol in a hu man breast cancer cell line显示文摘 | Osman AM Bayoumi HM AI Harthi SE | 2012 | Cancer Cell Int2012，12，1： | 1 |
| 14 | Biosynthesis of seopoletin and seopolin in cassava roots during post-harvest physiological deterioration :the E -Z -isomerisation stage 显示文摘 | BAYOUMI SA ROWAN MG BLAGBROUGH IS | 2008 | Phytoehemistry2008，69，17： | 1 |
| 15 | A survey of modeling and control of hybrid systems显示文摘 | Labinaz G Bayoumi M M Rudie K | 1997 | Annual Reviews in Control1997，21，： | 1 |
| 16 | Effect of surface finish on fatigue strength显示文摘 | Bayoumi M R Abdellatif A K | 1995 | Engineering Fracture Mechan- ics1995，51，5： | 1 |
| 17 | Applications of iterative elastic techniques for elastic-plastic analysis of pressure vessels显示文摘 | MOHAMED A I MEGAHED M M BAYOUMI L S | 1999 | Journal of Pressure Vessel Technology1999，121，： | 1 |
| 18 | Ever Close to Heaven? An Optimum Currency Area Index for European Coun- tries显示文摘 | Tamim Bayoumi Barry Eichengreen | 1997 | European Economic Review1997，，41： | 1 |
| 19 | Porosity estimation using a combination of Wyllie- Clemenceau equations in clean sand formation from acoustic logs 显示文摘 | Kamel M H Mabrouk W M Bayoumi A 1 | 2002 | Journal of Petroleum Science and Engineering2002，33，4： | 1 |
| 20 | One money or many ?: analyzing the prospects for monetary unification in various Parts of the world显示文摘 | Eichengreen B | 1994 | Princeton Studies in International Finance1994，，： | 1 |
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