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| 1 | Three-dimensional structure determination of capsid of Aedes albopicus C6/36 cell densovirus显示文摘The three-dimensional structure of capsid of Aedes albopictus C6/36 densovirus was determined to 14- resolution by electron cryomicroscopy and computer reconstruction. The triangulation number of the capsid is 1. There are 12 holes in each triangular face and a spike on each 5-fold vertex. The validity of the capsid and nucleic acid densities in the reconstructions was discussed. | CHENG Lingpeng1, CHEN Senxiong1, Jenifer M. Brannan2, Joanita Jakana3, ZHANG Qinfen1, Z. H. Zhou2 & ZHANG Jingqiang1 1. State Key Laboratory for Bio-control, Zhongshan University, Guangzhou 510275, China 2. Department of Pathology, Medicine University of Texas-Huston Medical School, Huston, TX77030, USA 3. National Center for Macromolecular Imaging, Baylor College of Medicine, Houston, TX77, USA | 2004 | Science China(Life Sciences)2004，47，3： | 4 |
| 2 | Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells显示文摘Objective:We aimed to perform a preliminary study of the association between induced pluripotent stem cell(iPS)-related genes and biological behavior of human colorectal cancer(CRC) cells,and the potential for developing anti-cancer drugs targeting these genes.Methods:We used real-time reverse transcriptase polymerase chain reaction(RT-PCR) to evaluate the transcript levels of iPS-related genes NANOG,OCT4,SOX2,C-MYC and KLF4 in CRC cell lines and cancer stem cells(CSCs)-enriched tumor spheres.NANOG was knockdowned in CRC cell line SW620 by lentiviral transduction.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assays,plate colony formation,and a mouse xenograft model were used to evaluate alterations in biological behavior in NANOG-knockdown SW620 cells.Also,mock-knockdown and NANOG-knockdown cells were treated with 5-fluorouracil(5-FU) and survival rate was measured by MTT assay to evaluate drug sensitivity.Results:A significant difference in the transcript levels of iPS-related genes between tumor spheres and their parental bulky cells was observed.NANOG knockdown suppressed proliferation,colony formation,and in vivo tumorigenicity but increased the sensitivity to 5-FU of SW620 cells.5-FU treatment greatly inhibited the expression of the major stemness-associated genes NANOG,OCT4,and SOX2.Conclusions:These results collectively suggest an overlap between iPS-related genes and CSCs in CRC.Quenching a certain gene NANOG may truncate the aggressiveness of CRC cells. | Zhong SHI1,Rui BAI1,Zhi-xuan FU1,Yong-liang ZHU2,Rong-fu WANG3,Shu ZHENG1(1Cancer Institute(Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Key Laboratory of Molecular Biology in Medical Sciences,Zhejiang Province,China),the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)(2Department of Gastroenterology,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China)(3Center for Cell and Gene Therapy,Department of Pathology and Immunology,Baylor College of Medicine,Houston,Texas 77030,USA) | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 4 |
| 3 | Transcription-inhibition and RNA-binding domains of influenza A virus matrix protein mapped with anti-idiotypic antibodies and synthetic peptides 显示文摘 | Ye Zhi-peng Baylor N W Wagner R R | 1989 | J Virol1989，63，9： | 1 |
| 4 | How photons start vision 显示文摘 | Baylor D | 1996 | Proc Natl Acad Sci USA1996，93，2： | 1 |
| 5 | Mosaic arrangement of ganglion cell receptive fields in rabbit retina显示文摘 | DeVries S H Baylor D A | 1997 | J Neurophysiol1997，78，： | 1 |
| 6 | Synchronous burst of action potentials in ganglion cells of the developing mammalian retina显示文摘 | Meistter M Wong RL Baylor DA | 1991 | Science1991，252，5008： | 1 |
| 7 | The identification of 2,4-diacetylphloroglucinol as an antifungal metabolite produced by cutaneous bacteria of the salamander Plethodon cinereus显示文摘 | Brucker R M Baylor C M Walters R L | 2008 | Journal of Chemical Ecology2008，34，1： | 1 |
| 8 | Aluminum salts in vaccines-US perspective 显示文摘 | Baylor NW Egan W Richman P | 2002 | Vaccine2002，20，3： | 1 |
| 9 | The pivotal role of tumor necrosis factor- in signaling apQptosis in intestinal epithelial cells under shock conditions 显示文摘 | Diebel LN Liberati DM Baylor AE ct al | 2005 | J Trau- ma2005，58，5： | 1 |
| 10 | Hepatotoxicity associated with nevirapine use显示文摘 | Baylor MS Johann-Liang R | | 0，，： | 1 |
| 11 | Inhibition of human T cell leukemla virus by the plant flavonoid baicalein(7-glucuronic acid ,5,6-dihydroxyflavone) 显示文摘 | Baylor NW Fu T Yan YD | 1992 | Thefect Dis1992，165，3： | 1 |
| 12 | Synchronous burts of action potentials in ganglion cells of the developing mammalian retina显示文摘 | Meister M Wong RL Baylor DA | 1991 | Science1991，252，： | 1 |
| 13 | Resting Thyroid and Leptin Hormone Changes in Women Following Intense, Prolonged Exercise Training显示文摘 | BAYLOR L S HACKNEY A C | 2003 | Eur J Appl Physiol2003，88，： | 1 |
| 14 | Transverse myelitis in2 patients with Bartonella henselae infection (cat scratch disease)显示文摘 | Baylor P Garoufi A Karpathios T | 2007 | Clin Infect Dis2007，45，4： | 1 |
| 15 | Inhibition of human T cell leukemia virus by the plant flavonoid baicalin (7- glucuronic acid, 5,6-dihydroxyflavone)显示文摘 | Baylor NW Fu T Yan YD | 1992 | J Infect Dis1992，165，3： | 1 |
| 16 | Synchronous bursts of action potentials in ganglion cells of the developing mammalian retina显示文摘 | MEISTER M WONG RO BAYLOR DA | 1991 | Science1991，252，5008： | 1 |
| 17 | Field emission properties of different forms of carbon显示文摘 | Merkulov Vladimir Lowndes Dounlas H Baylor Larry R | 2003 | Solid-State Electronics2003，45，14： | 1 |
| 18 | Immunoglobulina profile in breast milk from mothers delivering full term and preterm infants显示文摘 | Diebel LN Liberati DM | 2007 | J Immunopathol Pharmacol2007，20，1： | 1 |
| 19 | Efficacy data and HPV vaccination studies显示文摘 | Baylor NW Wharton M | 2009 | JAMA2009，302，24： | 1 |
| 20 | A three component conception of intuition: Immediacy sensing- relationships and reason显示文摘 | BAYLOR A | 1997 | New Ideas Psy1997，15，： | 1 |
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