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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Framing effects within the ethical decision making process of consumers显示文摘 | Bateman C R Fraedrich J P Iyer R | 2002 | Journal of Business Ethics2002，36，12： | 1 |
| 3 | Tools for chloroplast transformation in Chlan,ydomonas: expression vectors and a new dominant selectable marker 显示文摘 | Bateman J M Purton S | 2000 | Molecular General Genetetic2000，263，： | 1 |
| 4 | Benefits transfer of willingness to pay estimates and functions for health-risk reductions:a cross-country study显示文摘 | Brouwer R Bateman I J | | 0，，03： | 1 |
| 5 | Assignment of credit and blame for performance outcomes显示文摘 | Crant J M Bateman T S | | 0，，01： | 1 |
| 6 | Reperiiision injury following cerebral ischemia:pathophysiology,MR ima- ging,and potential therapies显示文摘 | Pan J Konstas A A Bateman B | 2007 | Neuroradiology2007，49，： | 1 |
| 7 | Mass Spectral Analyses of Microcystins from Toxic Cyanobacteria Using on-line Chromatographic and Electrophoretic Separations显示文摘 | Bateman K P Thibault P Douglas D J | 1995 | J Chromatogr A1995，712，： | 1 |
| 8 | Energy resolution in X - ray detecting micro - strip gas counters显示文摘 | Bateman J E Connolly J F Derbyshire G E | 2002 | Nucl Instr and Meth A2002，484，13： | 1 |
| 9 | Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma显示文摘 | HOWELL W M BATEMAN A C TURNER S J | 2002 | Hums Immun2002，3，： | 1 |
| 10 | Economic analysis of environmental preferences:Progress and prospects显示文摘 | Lovett A Bateman I J | 2001 | Computer Environment and Urban systems2001，25，： | 1 |
| 11 | Rising prevalence of aller-gy to peanut in children:data from 2 sequential cohorts显示文摘 | Grundy J Matthews S Bateman B | 2002 | J Allergy ClinImmunol2002，110，5： | 1 |
| 12 | MSE with mass defect filtering for in vitro and in vivo metabolite identification 显示文摘 | Bateman KP Castro -Perez J Wrona M | 2007 | Rapid Commun Mass Spectrom2007，21，9： | 1 |
| 13 | Economic analysis for ecosystem service assessments 显示文摘 | Bateman I J Mace G M Fezzi C | 2011 | Environmental and Resource Economics2011，48，2： | 1 |
| 14 | Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study显示文摘 | Bateman ED Boushey HA Bousquet J | | 0，，08： | 1 |
| 15 | Did railroads in- duce or follow economic growth? Urbanization and Pop- ulation Growth in the American Midwest, 1850 - 1860 显示文摘 | Atack J Bateman F and Haines M | 2010 | Social Science History2010，34，2： | 1 |
| 16 | Extreme ocean waves--part I: the practical application of fully nonlinear wave modeling显示文摘 | Bateman W J D Katsardi V Swan C | 2012 | Applied Ocean Research2012，34，： | 1 |
| 17 | The proactive component of organi- zational behavior: A measure and correlates 显示文摘 | Bateman T S Crant J M | 1993 | Journal of Organizational Behavior1993，14，2： | 1 |
| 18 | Rising prevalence of allergy to peanut in children:data from 2 sequential cohorts显示文摘 | Grundy J Matthews S Bateman B | 2002 | J Allergy Clin Immunol2002，110，： | 1 |
| 19 | Clinical and biomarker changes in dominantly inherited Alzheimer's disease显示文摘 | Bateman R J Xiong C Benzinger TL | 2012 | N Engl J Med2012，367，： | 1 |
| 20 | Effects of using wheat gluten and rice protein concentrate in dairy calf milk replacers显示文摘 | HILL T M BATEMAN H G ALDRICH J M | 2008 | The Professional Animal Scientist2008，24，5： | 1 |
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