|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients显示文摘Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases.Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure.Liver transplantation (LT) currently remains the only definitive treatment option for such cases,but is generally denied to patients suffering from malignancy.Here,the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma.These 2 cases,and some other reports in the literature,may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good. | Timothée Noterdaeme Luc Longrée Christian Bataille Arnaud Deroover Anne Lamproye Jean Delwaide Yves Beguin Pierre Honoré Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，25： | 6 |
| 3 | 选择性CD_(34)^+细胞和非选择性自体外周血干细胞移植治疗多发性骨髓瘤的比较研究显示文摘目的 明确选择性CD3 4+ 细胞自体外周血干细胞移植 (APBSCT)治疗多发性骨髓瘤 (MM)的临床效果。方法 对 2 1例接受CD3 4+ 细胞APBSCT治疗的MM患者 (选择组 )和另外 2 1例接受非选择性APBSCT的MM患者 (对照组 )的造血恢复时间、有效率、生存率、移植相关不良反应、移植费用进行比较。两组病例在年龄、初诊时血清 β2 微球蛋白水平和移植时疾病状态均具有可比性 ,诱导治疗及预处理方案基本相同。结果 与对照组相比 ,选择组患者回输的CD3 4+ 细胞数显著偏低 [对照组和选择组分别为 9.4(1.1~ 15 .0 )× 10 6/kg和 2 .2 (0 .5~ 14.3)× 10 6/kg](P <0 .0 0 1) ,中性粒细胞恢复至≥ 0 .5× 10 9/L和血小板恢复至≥ 2 0× 10 9/L的中位时间 ,在选择组分别为 10d和 9d ,对照组分别为 9.5d(P=0 .35 7)和 4.5d(P =0 .0 0 5 )。两组的治疗有效率相似 (选择组 85 .7% ,对照组 90 .4% ) ,3年无病生存率 (选择组和对照组分别为 32 %和 39% )和总生存率 (选择组和对照组分别为 85 %和 79% )两组相比差异无显著性 ,而且使用非选择性APBSCT可明显降低移植费用。结论 选择性CD3 4+ 细胞APBSCT与非选择性APBSCT相比 ,并不能改善MM的临床治疗结果 ,而且移植费用更大。 | 唐晓文 N Morineau N Milpied P Moreau R Bataille JL Harousseau | 2001 | 中华血液学杂志2001，22，7： | 5 |
| 4 | Role of soluble factors and three-dimensional culture in in vitro differentiation of intestinal macrophages显示文摘AIM: To examine the factor(s) involved in differentiation of intestinal macrophages (IMACs) using a recently established in vitro model. METHODS: To test whether soluble or membrane bound factors induce IMAC-differentiation, freshly elutriated monocytes (MO) were incubated with conditioned media or cell membranes of intestinal epithelial cells (IEC) or cultured with IEC in transwell systems. To determine the importance of an active migration of MO, three- dimensional aggregates from a 1:1-mixture of MO and IEC were examined by immunohistochemistry and flow cytometry. Apoptosis was examined by caspase-3 Western blots. Extracellular matrix production in differentiation models was compared by immunohistochemistry. RESULTS: IMAC differentiation was observed in a complex three-dimensional co-culture model (multicellular spheroid, MCS) with IEC after migration of MO into the spheroids. By co-culture of MO with conditioned media or membrane preparations of IEC no IMAC differentiation was induced. Co-culture of MO with IEC in transwell- cultures, with the two cell populations separated by a membrane also did not result in intestinal-like differentiation of MO. In contrast to IEC-spheroids with immigrating MO in mixed MCS of IEC and MO only a small subpopulation of MO was able to survive the seven day culture period. CONCLUSION: Intestinal-like differentiation of MO in vitro is only induced in the complex three-dimensional MCS model after immigration of MO indicating a roleof cell-matrix and/or cell-cell interactions during the differentiation of IMACs. | Tanja Spoettl Martin Hausmann Katrin Menzel Heidi Piberger Hans Herfarth Juergen Schoelmerich Frauke Bataille Gerhard Rogler | 2007 | World Journal of Gastroenterology2007，13，7： | 3 |
| 5 | Pathogen-associated molecular patterns are growth and survival factors for human myeloma cells through Toll-like receptors显示文摘 | Jego G Bataille R Geffroy-Luseau A | 2006 | Leukemia2006，20，6： | 1 |
| 6 | Multiplex amplification of mitochondrial DNA for human and species identification in forensic evaluation显示文摘 | Bataille M Crainic K Leterreux M | 1999 | Forensic Sci Int1999，99，： | 1 |
| 7 | New insight in the clinical bi- ology of multiple myeloma 显示文摘 | Bataille R | 1997 | Semin Ha- ematol1997，34，11： | 1 |
| 8 | Differential synthesis of glyceraldehyde-3-phosphate dehydrogenase polypeptides in stressed yeast ceUs显示文摘 | Boucherie H Bataille N Fitch IT | 1995 | FEMS Microbiology Letters1995，125，23： | 1 |
| 9 | The bone-resorbing activity of interleukin-6 显示文摘 | Bataille R Klein B | 1991 | J Bone Miner Res1991，6，10： | 1 |
| 10 | Sulfided Mo and CoMo supported on zeolite as hydrodesulfurization catalysts: Transformation of dibenzothiophene and 4,6-dimethyldibenzothio-phene显示文摘 | Bataille F Lemberton J L Perot G | 2001 | Appl Catal A2001，220，12： | 1 |
| 11 | biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma显示文摘 | BATAILLE R BARLOGIE B LU Z Y | 1995 | Blood1995，86，： | 1 |
| 12 | C-reactive protein and beta-2 microglobulin produce a simple and powerful myeloma staging system显示文摘 | BATAILLE R BOCCADORO M KLEIN B | 1992 | Blood1992，80，： | 1 |
| 13 | Primary intraeerebal malignant lymphoma: report of 248 cases显示文摘 | Bataille B Delwail V Menet E | 2000 | J Neurosurg2000，92，2： | 1 |
| 14 | Effects of irradiation on PVC compounds显示文摘 | P Bataille I Ulkem H P Schreiber | 1995 | Nuclear Instruments and Methods in Physics Research1995，，105： | 1 |
| 15 | Heart failure in acute myocardial infarction: a comparison between patients with or without heart failure criteria from the FAST-MI registry显示文摘 | Juilli ~ re Y Cambou JP Bataille V | 2012 | Rev Esp Cardiol (Engl Ed)2012，65，4： | 1 |
| 16 | Hemoglobin level- variability in hemodialysis patients treated with epoetin-β dur- ing 1 year显示文摘 | Kessler M Landais P Bataille P | 2011 | Clin Nephrol2011，76，3： | 1 |
| 17 | Aerodynamic design of micro air vehicles for vertical flight显示文摘 | SHKARAYEV S MOSCHETTA J M BATAILLE B | 2008 | Journal of Aircraft2008，45，5： | 1 |
| 18 | Genetics and cytogenetics of multiple myeloma:a workshop report显示文摘 | Fonseca R Barlogie B Bataille R | 2004 | Cancer Res2004，64，： | 1 |
| 19 | Effects of ectopic decorin in modulating intracranial glioma progression in vivo,in a rat syngeneic model显示文摘 | Biglari A Bataille D Naumann U | 2004 | Cancer Gene Ther2004，11，11： | 1 |
| 20 | New insights in myeloma-induced osteolysis显示文摘 | Barille-Nion S Bataille R | 2003 | Leuk Lymphoma2003，44，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员