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| 1 | Aging and menopause reprogram osteoclast precursors for aggressive bone resorption显示文摘Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing osteoporosis.The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes.However,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity.Therefore,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were collected.Using multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with age.We conclude that monocytes are'reprogrammed'in vivo,allowing them to'remember'age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive osteoclasts.Our discovery suggests that this may be mediated through DNA methylation.We suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss. | Anais Marie Julie Moller Jean-Marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe | 2020 | Bone Research2020，8，3： | 4 |
| 2 | Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2 显示文摘 | Fehrenbacher N Bastholm L Kirkegaard-Sprensen T | 2008 | Cancer Res2008，68，16： | 1 |
| 3 | Control of macroautophagy by calcium,calmodulin-dependent kinase kinase-beta,and Bcl-2显示文摘 | Hyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 4 | Control of macroautophagy by Calcium, Calmodulin-Dependent kinase Kinase-β, and Bcl-2 显示文摘 | Hoyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 5 | Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults 显示文摘 | Melo TM Sonnewald U Bastholm IA | 2007 | Neurobiol Dis2007，28，2： | 1 |
| 6 | Ischemia leads to apoptosis-and necrosis-like neuron death in the ischemic rat hippocampus显示文摘 | Muller GJ Stadelmann C Bastholm L | 2004 | Brain Pathol2004，14，： | 1 |
| 7 | Therapeutic synergy of TNP - 470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts 显示文摘 | Lund EL Bastholm L and Kristjansen PE | 2000 | Clin Cancer Res2000，6，： | 1 |
| 8 | Control ofmacroautophagy by calcium,calmodulindependent kinase kinase-beta,and Bcl-2显示文摘 | H0yer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 9 | Control of macroautophagy by calcium, calmodulin-dependent kinase kinase- 13, and Bcl-2 显示文摘 | Hoyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Ce112007，25，2： | 1 |
| 10 | Therapeutic Synergy of TNP-470 and ionizing radiation:Effects on tumor growth,vessel morphology,and angiogenesis in human glioblastoma multiforme xenografts显示文摘 | Lund EL Bastholm L Kristjansen PEG | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 11 | Control of macro- autophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2显示文摘 | Hoyer H M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 12 | Control of maeroautophagy by ealeium,ealmodulin -dependent kinase kinase-beta,and Bcl-2显示文摘 | Hoyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 13 | Control of macroautophagy by calcium, calmodulin-dependent kinase kinasebeta, and Bcl-2显示文摘 | Hyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 14 | Control of macroautophagy by calcium,calmodulin-dependent kinase kinase-beta,and Bcl-2显示文摘 | Hoyer-Hansen M Bastholm L Szyniarowski P | | 0，，2： | 1 |
| 15 | Control ofmacroautophagy by calcium, calmodulin-dependent kinasekinase-beta, and Bcl-2 显示文摘 | H0yer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 16 | Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angio- genesis in human glioblastoma multi- forme xenografts 显示文摘 | Lund EL Bastholm L Kristjansen PE | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 17 | Control of macroautophagy by calcium,calmodulin-dependent kinase kinasebeta,and Bcl-2显示文摘 | HOYER-HANSEN M BASTHOLM L SZYNIAROWSKI P | 2007 | Molecular Cell2007，25，2： | 1 |
| 18 | Control of macroautophagy by calcium, calmodulin-dependent kinase kinase- beta, and Bcl-2显示文摘 | Hcyer-Hansen M Bastholm L Szyniarowski P | 2007 | Mol Cell2007，25，2： | 1 |
| 19 | Ischemia leads to apoptosis-and necrosis-like neuron death in the isehemie rat hippoeampus显示文摘 | Muller GJ Stadelmann C Bastholm L | 2004 | Brain Pathol2004，14，4： | 1 |
| 20 | 显示文摘 | Damstrup L Wandahl-Pedersen M Bastholm L | 2002 | Int J Cancer2002，97，1： | 1 |
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