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| 1 | From fatty liver to fibrosis:A tale of “second hit”显示文摘Although much is known about how fat accumulates in the liver,much remains unknown about how this causes sustained hepatocellular injury.The consequences of injury are recognized as nonalcoholic steatohepatitis(NASH) and progressive fibrosis.The accumulation of fat within the hepatocytes sensitizes the liver to injury from a variety of causes and the regenerative capacity of a fatty liver is impaired.An additional stressor is sometimes referred to as a 'second hit' in a paradigm that identifies the accumulation of fat as the 'first hit'.Possible candidates for the second hit include increased oxidative stress,lipid peroxidation and release of toxic products such as malondialdehyde and 4-hydroxynonenal,decreased antioxidants,adipocytokines,transforming growth factor(TGF)-β,Fas ligand,mitochondrial dysfunction,fatty acid oxidation by CYPs(CYP 2E1,4A10 and 4A14),and peroxisomes,excess iron,small intestinal bacterial overgrowth,and the generation of gut-derived toxins such as lipopolysaccharide and ethanol.Oxidative stress is one of the most popular proposed mechanisms of hepatocellular injury.Previous studies have specifically observed increased plasma and tissue levels of oxidative stress markers and lipid peroxidation products,with reduced hepatic and plasma levels of antioxidants.There is also some indirect evidence of the benefit of antioxidants such as vitamin E,S-adenosylmethionine,betaine,phlebotomy to remove iron,and N-acetylcysteine in NASH.However,a causal relationship or a pathogenic link between NASH and oxidative stress has not been established so far.A number of sources of increased reactive oxygen species production have been established in NASH that include proinflammatory cytokines such as tumor necrosis factor(TNF)-α,iron overload,overburdened and dysfunctional mitochondria,CYPs,and peroxisomes.Briefly,the pathogenesis of NASH is multifactorial and excess intracellular fatty acids,oxidant stress,ATP depletion,and mitochondrial dysfunction are important causes of hepatocellular injury in the steatotic liver. | Metin Basaranoglu Gkcen Basaranoglu Hakan Sentürk | 2013 | World Journal of Gastroenterology2013，19，8： | 28 |
| 2 | Pathophysiology of insulin resistance and steatosis in patients with chronic viral hepatitis显示文摘Chronic hepatitis due to any cause leads to cirrhosis and end-stage liver disease.A growing body of literature has also shown that fatty liver due to overweight or obesity is a leading cause of cirrhosis.Due to the obesity epidemic,fatty liver is now a significant problem in clinical practice.Steatosis has an impact on the acceleration of liver damage in patients with chronic hepatitis due to other causes.An association between hepatitis C virus (HCV) infection,steatosis and the onset of insulin resistance has been reported.Insulin resistance is one of the leading factors for severe fibrosis in chronic HCV infections.Moreover,hyperinsulinemia has a deleterious effect on the management of chronic HCV.Response to therapy is increased by decreasing insulin resistance by weight loss or the use of thiazolidenediones or metformin.The underlying mechanisms of this complex interaction are not fully understood.A direct cytopathic effect of HCV has been suggested.The genomic structure of HCV (suggesting that some viral sequences are involved in the intracellular accumulation of triglycerides),lipid metabolism,the molecular links between the HCV core protein and lipid droplets (the core protein of HCV and its transcriptional regulatory function which induce a triglyceride accumulation in hepatocytes) and increased neolipogenesis and inhibited fatty acid degradation in mitochondria have been investigated. | Metin Basaranoglu Gkcen Basaranoglu | 2011 | World Journal of Gastroenterology2011，17，36： | 8 |
| 3 | Mallory-Denk Bodies in chronic hepatitis显示文摘Mallory-Denk Bodies(MDB) are important as investigators,suggesting MDB as an indicator of the histologic severity of chronic hepatitis,causes of which include hepatitis C,primary biliary cirrhosis(PBC),and nonalcoholic fatty liver disease(NAFLD).Matteoni et al scored MDB in patients with NAFLD as none,rare and many,and reported that MDB plays a prominent role in this classification scheme in an earlier classification system.In this study,we evaluated 258 patients with chronic hepatitis due to metabolic,autoimmune and viral etiologies.Liver biopsy samples were evaluated with hematoxylin and eosin,periodic acid-Schiff-diastase,Gordon and Sweet's reticulin,Masson's trichrome,and iron stains.Both staging and grading were performed.Additionally,MDB were evaluated and discussed for each disease.We examined patients with nonalcoholic steatohepatitis(NASH;50 patients),alcoholic hepatitis(10 patients),PBC(50 patients),Wilson disease(WD;20 patients),hepatitis B(50 patients),hepatitis C(50 pati-ents) and hepatocellular carcinoma(HCC;30 patients).Frequency of MDB was as follows;NASH:10 patients with mild in 60% and moderate in 40% and observed in every stage of the disease and frequently seen in zone 3.PBC:11 patients with mild in 10%,moderate in 70%,and cirrhosis in 20%,and frequently seen in zone 1.WD:16 patients with moderate and severe in 60% and cirrhosis in 40% and frequently seen in zone 1.Hep B:3 patients with mild in 66% and severe in 34%.Hep C:7 patients with mild in 40% and moderate in 60% and observed in every stage.HCC:3 patients with hep B in 2 patients.We found that there is no relationship between MDB and any form of chronic hepatitis regarding histologic severity such as alcoholic steatohepatitis and NAFLD and variable zone distribution by etiology. | Metin Basaranoglu Nesrin Turhan Abdullah Sonsuz Gkcen Basaranoglu | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 4 | Smoking and postoperative analgesia 显示文摘 | ErdenV Basaranoglu G Delatioglu H eta1 | 2005 | Ann Pharmacother2005，39，9： | 1 |
| 5 | Reduction of pain on injection of propofol using mepiridine and remifentanil显示文摘 | Basaranoglu G Erden V Delatioglu H | 2005 | Eur J Anaesthesiol2005，22，11： | 1 |
| 6 | Reduction of pain on injection of propofol using meperidine and rernifen- tanil显示文摘 | Basaranoglu G Erden V Delatioglu H | 2005 | Eur J Anaesthesiol2005，22，11： | 1 |
| 7 | Reduction of pain on injec-tion of propofol:a comparison of fentanyl with remifentanil显示文摘 | Basaranoglu G Erden V Delatioglu H | 2012 | Anesthesia and Analgesia2012，33，1： | 1 |
| 8 | Reduction of pain on injection of propofol : a comparison of fentanyl with remifentanil 显示文摘 | Basaranoglu G Erden V Delatioglu H | 2002 | Anesth Analg2002，94，4： | 1 |
| 9 | Postoperative sore throat: effect of lidocaine jelly and pomade on endotracheal intubation 显示文摘 | Basaranoglu G Erden V Delatioglu H | 2004 | J Clin Anesth2004，16，1： | 1 |
| 10 | Time course of collagenpeak in bile duct-ligated rats显示文摘 | Tarcin O Basaranoglu M Tahan G | 2011 | BMC Gastroenterol2011，11，： | 1 |
| 11 | Reduction of pain on injection of propofol: a comparison of fentainil with remifentanil显示文摘 | Basaranoglu G Erden V Delatioglu H | 2002 | Anesth Analg2002，94，4： | 1 |
| 12 | Reduction of pain on injection of propofol: a comparison of fentanyl with remifentauil 显示文摘 | Basaranoglu G Erden V Delatioglu H | 2002 | Anesth Analg2002，94，4： | 1 |
| 13 | Telenutrition for the management of inflammatory bowel disease:Benefits,limits,and future perspectives显示文摘Patients with inflammatory bowel disease(IBD)require lifelong and personalized care by a multidisciplinary healthcare team.However,the traditional medical model is not ideal for patients who require continuous close monitoring and whose symptoms may dramatically worsen between regularly scheduled visits.Additionally,close dietary follow-up and monitoring of IBD in a traditional setting are challenging because of the disease complexity,high pressure on outpatient clinics with a small number of IBD specialist dietitians,and rising incidence.Given the significant burden of IBD,there is a need to develop effective dietary management strategies.The coronavirus disease 2019 pandemic caused an unprecedented shift from in-person care to delivering health care via technological remote devices.Traditional nutrition therapy and consultation can be provided by telenutrition through remote electronic communication applications that could greatly benefit patient care.Telenutrition might be useful,safe,and cost-effective compared with standard care.It is likely that virtual care for chronic diseases including IBD will continue in some form into the future.This review article summarizes the evidence about telenutrition applications in the management of IBD patients,and we gave an overview of the acceptance and impact of these interventions on health outcomes. | Merve Güney Coşku Ezgi Kolay Metin Basaranoglu | 2023 | World Journal of Clinical Cases2023，11，2： | 0 |
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