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| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides显示文摘 | Zhong M Munzer JS | 2001 | Biochem J2001，353，3： | 1 |
| 3 | Studies on jutereinforced composites,its limitations,and some solutions through chemical modifications of fibers显示文摘 | MITRA B C BASAK R K SARKAR M | 1998 | Journal of Applied Polymer Science1998，67，6： | 1 |
| 4 | Increased dendritic cell number and function following continuous in vivo infusion of granulocyte macrophage-colony-stimulating factor and interleukin-4 显示文摘 | Basak S K Harui A Stolina M | 2002 | Blood2002，99，8： | 1 |
| 5 | Comparisons of oral calcium, high dose vitamin D and a combination of these in the treatment of nutri- tional rickets in children显示文摘 | Kutluk G Cetinkaya F Basak M | 2002 | J Trop Pediatr2002，48，6： | 1 |
| 6 | Traumatic lingual ulcer in a child: Riga-Fede disease显示文摘 | Ceyhan AM Yildirim M Basak PY | 2009 | Clin Exp Dermatol2009，34，2： | 1 |
| 7 | Increased dendritic cell number and function following continuous in vivo infusing of granulocyte macrophage colony stimulating factor and interleukin-4显示文摘 | Harui A Stolina M | 2002 | Blood2002，99，8： | 1 |
| 8 | Inhibition of proprotein convertases-1 ,- 7 and furin by diterpines of Andrographis paniculata and their succinoyl esters显示文摘 | Basak A Cooper S Roberge A G Banik U K Chretien M Seidah N G | 1999 | Biochem J1999，338，1： | 1 |
| 9 | Implication of the proprotein convertases furin,PC5and PC7in the cleavage of surface glyco-proteins of HongKong,Ebola and respiratory syncytial viruses:a comparative analysis with fluorogenic peptides显示文摘 | Basak A Zhong M Munzer JS | 2001 | Biochem J2001，353，3： | 1 |
| 10 | Behaviour of Li isotopes during continental weathering:the Bidar laterite profile,India显示文摘 | Basak K1sakürek Widdowson M James R H | 2004 | Chemical Geology2004，212，： | 1 |
| 11 | Role of pro-IGF-Ⅱ processing by proprotein convertase 4 in human placental development显示文摘 | Qiu Q Basak A Mbikay M | 2005 | Proc Natl Acad Sci USA2005，102，11： | 1 |
| 12 | A Novel 2-D Graphical Representation of DNA Sequences of Low Degeneracy显示文摘 | Guo Xiaofeng Randic M Basak S C | 2001 | Chemical Physics Letters2001，350，12： | 1 |
| 13 | A randomized double-blind placebo-con-trolled clinical study on the effects of gabapentin premedication on hemody-namic stability during laparoscopic cholecystectomy显示文摘 | Neogi M Basak S Ghosh D | 2012 | J Anaesthesiol Clin Pharmacol2012，28，4： | 1 |
| 14 | Microwave-assisted Michael reactions of 3-(2-nitrovinyl)indole with indoles on TLC grade silica gel~ a new, facile synthesis of 2,2-bis(3- indolyl)nitroethanes显示文摘 | Chakrabarty M Basak R Ghosh N | 2001 | Tetrahedron Letters2001，42，： | 1 |
| 15 | Inhibition of rat C6 glioblastoma tumor growth by expression of insulin-like growth factor I receptor antisense mRNA显示文摘 | Resnicoff M Li W Basak S | 1996 | Cancer Immunol Immunother1996，42，1： | 1 |
| 16 | Interaction of phosphorus and molybdenum in relation to uptake and utilization of molybdenum, phosphorus, zinc, copper and manganese by rice显示文摘 | Basak A Mandal L N Haldar M | 1982 | Plant Soil1982，68，2： | 1 |
| 17 | A so- journ in the synthesis and bioactivity of diindolylalkanes 显示文摘 | CHAKRABARTY M BASAK R HARIGAYA Y | 2001 | neterocycles2001，55，12： | 1 |
| 18 | On 3-D graphicai representation of DNA primary sequences and their numerical characterization显示文摘 | Randic M Vraeko M Basak S C | 2000 | Chem Inf Comput Sci2000，40，5： | 1 |
| 19 | Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadiurn and 1, 25-dihydroxyvitamin D3显示文摘 | Basak R Saha BK Chatterjee M | 2000 | Biochem Biophys Acta2000，150，： | 1 |
| 20 | Analytical solutions of sand drain problem显示文摘 | BASAK P MADHAV M R | 1978 | Journal of Geotechnical engineering ASCE1978，104，： | 1 |
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