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| 1 | Increased syndecan-1 and glypican-3 predict poor perinatal outcome and treatment resistance in intrahepatic cholestasis显示文摘Background:Intrahepatic cholestasis of pregnancy(ICP)increases the risk of adverse pregnancy outcomes.This study aimed to explore the association between serum syndecan-1 and glypican-3 levels and the adverse perinatal outcome as well as the responses to the treatment of ursodeoxycholic acid(UDCA).Methods:This prospective,case control study included 88 pregnant women(44 women with ICP and 44 healthy controls).The primary end points were the perinatal outcome and the response to UDCA therapy.A logistic regression model was used to identify the independent risk factors of adverse pregnancy outcomes and reduced response to UDCA therapy.Results:Women with ICP had significantly higher serum syndecan-1(1.27±0.36 ng/m L vs.0.98±0.50 ng/m L;P=0.003),glypican-3(1.78±0.13 ng/m L vs.1.69±0.16 ng/m L;P=0.004),AST(128.59±1.44 vs.13.29±1.32 U/L;P<0.001),and ALT(129.84±1.53 vs.8.00±3.67 U/L;P<0.001)levels compared with the controls.The increased levels of syndecan-1(OR=4.715,95%CI:1.554–14.310;P=0.006),glypican-3(OR=8.465,95%CI:3.372–21.248;P=0.007),ALT(OR=1.382,95%CI:1.131–1.690;P=0.002),and postprandial bile acid(PBA)(OR=3.392,95%CI:1.003–12.869;P=0.026)were correlated to ICP.The adverse neonatal outcome was related to increased glypican-3(OR=4.275,95%CI:2.726–5.635;P=0.039),and PBA(OR=3.026,95%CI:1.069–13.569;P=0.037).Increases of syndecan-1(OR=7.464,95%CI:2.130–26.153,P=0.017)and glypican-3(OR=6.194,95%CI:2.951–13.002;P=0.025)were the risk factors of decreased response to UDCA treatment.Conclusion:Syndecan-1 and glypican-3 might be powerful determinants in predicting adverse perinatal outcome in patients with ICP,and they can be used to predict the response to the UDCA treatment. | Basak Gümüs Güler Sibel Ozler | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 3 |
| 2 | Comparisons of oral calcium, high dose vitamin D and a combination of these in the treatment of nutri- tional rickets in children显示文摘 | Kutluk G Cetinkaya F Basak M | 2002 | J Trop Pediatr2002，48，6： | 1 |
| 3 | Inhibition of proprotein convertases-1 ,- 7 and furin by diterpines of Andrographis paniculata and their succinoyl esters显示文摘 | Basak A Cooper S Roberge A G Banik U K Chretien M Seidah N G | 1999 | Biochem J1999，338，1： | 1 |
| 4 | Photoconductive UVdetectors on sol - gel - synthesized ZnO films 显示文摘 | Basak D Amin G Mallik B | 2003 | Journal of Crystal Growth2003，256，： | 1 |
| 5 | Computation of magnetic field in DC brushless linear motors built with NdFeB magnets 显示文摘 | BASAK A SHIRKOOHI G H | 1990 | IEEE Transactions on Magnetics1990，26，2： | 1 |
| 6 | The secretory proprotein convertases furin,PC5,and PC7 activate VEGF-C to induce tumorigenesis显示文摘 | Siegfried G Basak A Cromlish JA | 2003 | J Clin Invest2003，111，11： | 1 |
| 7 | Effect of thermal annealing treatment on structural, electrical and optical properties of transparent sol-gel ZnO thin films 显示文摘 | Ghosh R Paul G K Basak D | 2005 | Mater Res Bull2005，40，11： | 1 |
| 8 | Stability in distribution for a class of singular diffusion显示文摘 | BASAK G K BHATTACHARYA R N | 1992 | Ann Probab1992，20，： | 1 |
| 9 | Evaluation of activatory and inhibitory natural killer cell receptors in non-segmental vitiligo: a flow cytometrie study显示文摘 | Basak P Y Adiloglu A K Koc I G | 2008 | J Eur Acad Dermatol Venereol2008，22，8： | 1 |
| 10 | Photoconductive detector on sol-gel-synthsized ZnO films显示文摘 | Basak D Amin G | 2003 | Journal of Crystal Growth2003，256，： | 1 |
| 11 | Comparative study of topological and geometrical parameters in estimating normal boiling points and octanol water partition coefficient显示文摘 | BASAK A C GUTE B D GRUNWALD G D | 1996 | J Chem Inf Comput Sci1996，36，： | 1 |
| 12 | Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases显示文摘 | Siegfried G Basak A Prichett-Pejic W | 2005 | Oncogene2005，24，46： | 1 |
| 13 | Effect of thermal annealing treatment on structural, electrical and optical properties of transparent sol-gel ZnO thin films 显示文摘 | Ghosh R Paul G K Basak D | 2005 | Mater Res Bull2005，40，11： | 1 |
| 14 | Efficacy and recovery of calcium during Casi cored wire injection in steel melts显示文摘 | BASAK S KUMAR D ROY G G | 2010 | Ironmaking and Steelmaking2010，37，3： | 1 |
| 15 | Optisol corneal storage medium显示文摘 | Panda A Kamasr G Basak SK | 1994 | Acta Ophthalmol Copenh1994，72，5： | 1 |
| 16 | The secretory proprotein convertases furin,PCS,and PC7 activate VtF-C to induce tumorigenesis显示文摘 | Siegfried G Basak A Cromlish JA | 2003 | J Clin Invest2003，111，11： | 1 |
| 17 | Effect of thermal annealing treatment on structural, electrical and optical properties of transparent sol-gel ZnO thin films 显示文摘 | Ghosh R Paul G K Basak D | 2005 | Mater Res Bull2005，40，： | 1 |
| 18 | Photoconductive UVdetectors on sol- gel-synthesized ZnO films显示文摘 | Basak D Amin G Mallik B | 2003 | J Crystal Growth2003，256，12： | 1 |
| 19 | Inhibition of propr1 rein convertases-1,7-and furin by diterpines of Andrograpl] paniculata and their sueeinoyl esters显示文摘 | Basak A Cooper S Roberge A G | 1999 | Bioehem J1999，31，1： | 1 |
| 20 | Photoconductive UV detectors on sol-gel-synthesized ZnO films显示文摘 | Basak D Amin G Mallik B | 2003 | J Crystal Growth2003，256，： | 1 |
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