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| 1 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 2 | PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke:Relation to outcome显示文摘 | Marchal G Serrati C Baron J | 1993 | Lancet1993，341，： | 2 |
| 3 | Docetaxel and oxaliplatin combination in second-line treatment of patients with advanced gastric cancer显示文摘 | Barone C Basso M Schinzari G | 2007 | Gastric Cancer2007，10，2： | 1 |
| 4 | Pancreaticobiliary and duode- nal perforations after periampullary endoscopic proce- dures : diagnosis and management显示文摘 | Fatima J Baron T H Topazian M D Houghton S G Iqbal C W Ott B J | 2007 | Arch Surg2007，142，： | 1 |
| 5 | Guidelines for Conscious Sedation and Monitoring During Gastrointestinal Endoscopy显示文摘 | J.Patrick Waring Todd H Baron William K Hirota Jay L Goldstein Brian C Jacobson Jonathan A Leighton J.Shawn Mallery Douglas O Faigel | 2003 | Gastrointestinal Endoscopy2003，，3： | 1 |
| 6 | Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symp- tomatic intracerebral hemorrhage显示文摘 | Baron J C Farid K Dolan E | 2014 | J Cereb Blood Flow Metab2014，34，5： | 1 |
| 7 | Protein oxidation in muscle foods:A review显示文摘 | LUND M N HEINONEN M BARON C P | 2011 | Molecular Nutrition and Food Research2011，55，1： | 1 |
| 8 | Perfusion thresholds in human cerebral ischemia: historical perspective and therapeutic implications 显示文摘 | Baron J C | 2001 | Cerebrovas Dis2001，11，1： | 1 |
| 9 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure显示文摘 | Baron H G Wayne M G Santiago C | 2005 | Surg Endosc2005，19，1： | 1 |
| 10 | Management of skin toxicity associated with cetuximab treatment in combina- tion with chemotherapy or radiotherapy 显示文摘 | PINTO C BARONE CA GIROLOMONI G | 2011 | Oncologist2011，16，2： | 1 |
| 11 | The role of cytoki- nesin the neuropathology of stroke and neurotrama 显示文摘 | FEUERSTEIN G Z WANG X BARONE F C | 1998 | Neuroi - mmunomodulation1998，5，34： | 1 |
| 12 | Diagnosing entero- ccles using dynamic magnetic resonance imaging显示文摘 | Lienermann A Anthuber C Baron A | 2000 | Dis Colon Rectum2000，43，2： | 1 |
| 13 | Oxidation of lipid and protein inhorse mackerel (trachurus trachurus) mince and washed minces during processing and storage 显示文摘 | EYMARD S BARON CP JACOBSEN C | 2009 | Food Chemistry2009，114，1： | 1 |
| 14 | Acute biliary conditions 显示文摘 | de C Ferreira LE Baron TH | 2013 | Best Pract Res Clin Gastroenterol2013，27，5： | 1 |
| 15 | Treatment of severe chronic venous insufficiency using the subfascial endoscopic perforator vein procedure 显示文摘 | BARON H C WAYNE M G SANTIAGO C A | 2005 | Surg Endosc2005，19，1： | 1 |
| 16 | In vitro generation of dendritic cells from human blood monocytes in experi- mental conditions compatible for in vivo cell therapy 显示文摘 | Cao H Ver96 V Baron C | 2000 | J Hematother Stem Cell Res2000，9，2： | 1 |
| 17 | Cytokines in brain ischemia the role of TNF alpha 显示文摘 | FEUERSTEIN G WANG XINKANG BARONE F C | 1998 | Cell Mol Neurobiol1998，18，6： | 1 |
| 18 | Brain cooling during transient focal ischemia provides complete neuroprotection显示文摘 | Barone F C Feuerstein G Z White R F | 1997 | Neurosci Biobehav Rev1997，21，： | 1 |
| 19 | Technical and economical aspects of the use of limestone filler additions in cement 显示文摘 | BARON J DOURVE C | 1987 | World Cem1987，18，4： | 1 |
| 20 | Evaluation of activ- ity of selected antioxidants on proteins in solution and in emulsions显示文摘 | BARON C P BERNER L SKIBSTED L H | 2005 | Free radical research2005，39，： | 1 |
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