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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer ' s disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 2 |
| 3 | ELectrochemical in-vestigation of the energetics of particulate titanium dioxide photocatalysts: the methyl viologen-acetate system 显示文摘 | Ward M D White J R Bard A J | 1983 | Journal of American Chemical Society1983，105，： | 1 |
| 4 | Environmental processes of the ice age: land, oceans, glaciers (EPILOG) 显示文摘 | Mix A C Bard E Schneider R | 2001 | Quat Sci Rev2001，20，： | 1 |
| 5 | Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer' s disease-like neuropathology显示文摘 | Bard F Barbour R Cannon C | 2003 | Proc Natl Acad Sci USA2003，100，4： | 1 |
| 6 | Evaluation and prediction of the degradation of a cots CCD induced by displacement damage 显示文摘 | Germanicus R Barde S Dusseau L | 2002 | IEEE trans nucl sci2002，49，6： | 1 |
| 7 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer's disease 显示文摘 | Bard F Cannon C Barbour R | 2000 | Nature Medicine2000，6，8： | 1 |
| 8 | Heuristics for the flow line problem with setup costs 显示文摘 | Rios- Mercado R Z Bard J F | 1998 | European Journal of Operational Research1998，110，1： | 1 |
| 9 | Epitode and isotype specificities of antibodies toβ-amyloid peptide for protection against Alzheimer's disease-like neuropathology 显示文摘 | Bard F Barbour R Cannon C | 2003 | Proc Natl Acad Sci USA2003，100，4： | 1 |
| 10 | Do Servant-leaders Help Satisfy Follower Needs? An Organizational Justice Perspective 显示文摘 | Mayer D M Bardes M Piccolo R F | 2008 | European Journal of Work and Organizational Psychology2008，17，2： | 1 |
| 11 | Detecting bird sounds in a complex acoustic environment and application to bioacoustic too-nitoring 显示文摘 | BARDELI R WOLFF D KURTH F | 2010 | Pattern Recognition Letters2010，31，12： | 1 |
| 12 | Quantitative NMR for bioanalysis and metabolomics显示文摘 | Barding GA Jr Salditos R Larive CK | 2012 | Anal Bioanalyt Chem2012，404，4： | 1 |
| 13 | Excess risk of fatal coronary heart disease associated with diabetes in men and women:meta-analysis of 37 prospective cohort studies显示文摘 | Huxley R Bard F Woodward M | 2006 | BMJ2006，332，7533： | 1 |
| 14 | Coecolith chemistry reveals secular variations in the global ocean carbon cycle显示文摘 | Rickaby R Bard E Sonzogni C | 2007 | Earth and Planetary Science Letters2007，253，： | 1 |
| 15 | A machine setup and component placement in printed circuit board assembly显示文摘 | Bard J F Clayton R W Feo T | 1994 | Intemational Journal of Flexibile Manufacturing Systems1994，6，1： | 1 |
| 16 | Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 1 |
| 17 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 1 |
| 18 | Does High Qual- ity Leader - member Exchange Accentuate the Effects of Organi- zational Justice显示文摘 | Piccolo R F Bardes M Mayer D M Judge T A | 2008 | European Journal of Work and Organizational Psychology2008，7，： | 1 |
| 19 | Damage control surgery for thoracic injuries显示文摘 | ROTONDO M F BARD M R | 2004 | Injury2004，35，7： | 1 |
| 20 | Results of different surgical procedures on total knee arthroplasty infections显示文摘 | Barde R Rosenberg A | 1996 | J Arthroplasty1996，11，： | 1 |
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