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1Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism显示文摘PTPN22 has been previously found associated with coronary artery disease(CAD). In the present note we have studied the effect of p53 codon 72,acid phosphatse locus 1(ACP1) and adenosine deaminase(ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD,122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular diseasewithout CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1,p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders.Fulvia Gloria-Bottini Patrizia Saccucci Maria Banci Paolo Nardi Mattia Scognamiglio Antonio Pellegrino Egidio Bottini Luigi Chiariello 2014World Journal of Cardiology2014,6,6:2
2Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger 2000lnternation Journal of Applied Earth Ob- servation and Geoinformation2000,2,2:1
3Characterization of the binding interface between the copper ehaperone Atxl and the first eytosolie domain of Cee2 ATPase显示文摘ARNESANO F BANCI L BERTINI I 2001J Biol Chem2001,276,41:1
4The unusually stablequaternary structure of human Cu, Zn-superoxide dismutase-1 is controlled by both metal occupancy and disulfide status显示文摘Amesano F Banci L Bertini I 2004J Biol Chem2004,279,47:1
5Metalloehaperones and metaltransporting ATP ases:A comparative analysis of sequence and structures显示文摘Arnesnao F Banci L Bertini I 2002Genome Research2002,12,2:1
6The use of pseudocontact shifts to refine solution structures of paramagnetic metalloproteins: Met80Ala eyano-cytochrome c as an example显示文摘Banci L Bertini I Bren K L 1996J Biol Inorg Chem1996,1,2:1
7Pseudocontact shifts as constraints for energy minimization and molecular dynamics calculations on solution structures of paramagnetic metalloproteins显示文摘Banci L Bertini I Savellini G G 1997Proteins1997,29,1:1
8Counting the zinc-proteinsencoded in the human genome显示文摘Andteini C Banci L Bertini I 2006Proteome Res2006,5,1:1
9Adenosine Deaminase Genetic Polymorphism and Coronary Artery Disease 显示文摘Banci M Saccucci P Federica D 2009Cardi- ology2009,112,1:1
10Metallochaperones and metaltransporting ATPases:a comparative analysis of sequences and structures显示文摘Arnesano F Banci L Bertini I 2002Genome Research2002,12,:1
11The solution structure of reduced dimeric copper zinc superoxide dis- mutase 显示文摘BANCI L BERTINI I CRAMARO F 2002Eur J Biochem2002,269,7:1
12Counting the zinc-proteins encoded in the human genome显示文摘Andreini C Banci L Bertini I 2006J Proteome Res2006,5,1:1
13Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis显示文摘Banci L Bertini I Calderone V 2013Proc Natl Acad Sci USA2013,110,18:1
141H-NMR study of reduced heme proteins myoglobin and cytochrome P450 显示文摘Banci L Bertini I Marconi S 1993Eur J Biochem1993,215,2:1
15Cellular copper distribution:a mechanistic systems biology ap- proach 显示文摘BANCI L BERTINI I CANT1NI F 2010Cellular and Molecular Life Sciences2010,67,15:1
16Metallochaperones and Metal-Transporting ATPases: A Comparative Analysis of Sequences and Structures显示文摘 Banci L Bertini I 2002Genome Res2002,12,:1
17SOD1 and amyotrophic lateral sclerosis:mutations and oligomerization显示文摘BANCI L BERTINI I BOCA M 0,,02:1
18Bioinformatic comparison of structures and homology-models of matrix metalloproteinases显示文摘Andreini C Banci L Bertini I 2004J Proteome Res2004,3,1:1
19Reliability of vis ual and quantitative hepatobiliary scintigraphy in the follow-up of patients who have undergone eholecystectomy and transduodenal sphincteroplasty显示文摘Banci M Ierardi M Tiberio NS 1999Clin Nucl Med1999,24,5:1
20Structural properties of peroxidases显示文摘Banci L 1997Biotechnol1997,53,:1
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