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| 1 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 2 | A model of destination image formation显示文摘 | Seyhmus Baloglu Ken W. McCleary | 1999 | Annals of Tourism Research1999，，4： | 3 |
| 3 | Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?显示文摘AIM: To study the levels of adiponectin in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD) in comparison with control group.METHODS: Thirty-five patients who had elevated serum aminotransferase levels with bright liver and 34 healthy volunteers without liver disease were evaluated. Age,gender and body mass index (BMI) were recorded. Fasting plasma glucose, insulin, adiponectin, proinsulin and lipid profile were measured. A standard oral glucose tolerance test (OGTT) with insulin response was performed and the index of insulin resistance was calculated according to the homeostasis model assessment (HOMA) method.RESULTS: According to the OGTT results, none of the participants had diabetes. Serum adiponectin levels were statistically significantly lower in patients with NAFLD than in control group (8.14±3.4 μg/mL vs12.4±9.4 μg/mL,respectively, P<0.01). A statistically significant correlation was found between adiponectin and BMI (r: -0.33, P<0.01),HOMA (r: -0.26, P<0.05), proinsulin (r: -0.32, P<0.01),AST (r: -0.25, P<0.05), ALT (r: -0.26, P<0.05) or GGT (r: -0.22, P<0.05). In multiple regression analysis models,adiponectin levels were the only predictor of NAFLD in males, whereas in female group it was the BMI.CONCLUSION: Low adiponectin level might be a predictor of NAFLD especially in male nondiabetics. | Haluk Sargin Mehmet Sargin Hülya Gozu Asuman Orcun Gülcan Baloglu Murat Ozisik Mesut Seker Oya Uygur-Bayramicli | 2005 | World Journal of Gastroenterology2005，11，37： | 3 |
| 4 | An Investigation of the Validity and Reliability of the Adapted Mathematics Anxiety Rating Scale-short Version (MARS-SV)Among Turkish Students 显示文摘 | Baloglu M | 2010 | European Journal of Psychological Education2010，25，： | 1 |
| 5 | The website design and intemet site marketing practices of upscale and luxury hotels in Turkey 显示文摘 | Baloglu S Pekcan Y A | 2006 | Tourism Management2006，27，1： | 1 |
| 6 | A randomized controlled trial of a new ovule formulation of ornidazole for the treatment of bacterial vaginosis显示文摘 | Baloglu E Ozyazici M Baloglu A | 2003 | J Clin Pharm Ther2003，28，2： | 1 |
| 7 | Knuckle pads,leukonychia and deafness显示文摘 | Kose O Baloglu H | 1996 | Int J Dermatol1996，35，10： | 1 |
| 8 | A model of customer-based brand equity and its application to multiple destinations显示文摘 | Boo S Busser J Baloglu S | 2009 | Tourism Management2009，30，2： | 1 |
| 9 | Tourism destination images of Turkey, Egypt, Greece, and Italy as perceived by US-based tour operators and travel agents 显示文摘 | Seyhmus Baloglu Mehmet Mangaloglu | 2001 | Tourism Mangement2001，22，1： | 1 |
| 10 | Affective images of tourism destinations显示文摘 | Baloglu S Brinberg D | | 0，，04： | 1 |
| 11 | Nonhost community resident reactions to the 2002 Winter Olympics: The spillover impacts显示文摘 | Decio C Baloglu S | 2002 | Journal of Travel Research2002，41，1： | 1 |
| 12 | Association meeting planners' perceptions of five major convention cities Results of the pre - test 显示文摘 | Baloglu S Love C | 2001 | Journal of Convention & Exhibition Management2001，3，1： | 1 |
| 13 | Affeetive images of tourism desti- nation 显示文摘 | Baloglu S Brinberg D | 1997 | Journal of Travel Research1997，30，： | 1 |
| 14 | Image variations of Turkey by familiarity index: informational and experiential dimensions显示文摘 | Seyhmus Baloglu | 2001 | Tourism Management2001，，： | 1 |
| 15 | A Model of Destination Image Formation显示文摘 | BALOGLU & MCCLEARY | 1999 | Annals of Tourism Research1999，26，： | 1 |
| 16 | Multivariate effects of gender, ownership, and the frequency of use on computer anxiety among high school students 显示文摘 | Baloglu M Cevik V | 2008 | Computers in Human Behavior2008，24，6： | 1 |
| 17 | Tourism destination images ofTurkey, Egypt, Greece, and Italy as perceived by US-based touroperators and travel agents显示文摘 | Baloglu S Mangaloglu M | 2001 | Tourism Management2001，22，1： | 1 |
| 18 | The efficacy of dinopr- ostone vaginal insert for active management of premature rupture of membranes at term : a randomized controlled trial 显示文摘 | Bezircioglu I Akin MK Baloglu A | 2012 | Clin Exp Obstet Gynecol2012，39，3： | 1 |
| 19 | A model of customer-based brand equity and its application to multiple destinations显示文摘 | Boo S Busser J Baloglu S | 2009 | Tourism Management2009，30，2： | 1 |
| 20 | 显示文摘 | BALOGLU E HOCH J M CHATTERJEE S K | 2003 | Bioorganic & Medicinal Chemistry2003，11，7： | 1 |
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