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| 1 | Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer’s disease显示文摘Aging is by far the most prominent risk factor for Alzheimer’s disease(AD),and both aging and AD are associated with apparent metabolic alterations.As developing effective therapeutic interventions to treat AD is clearly in urgent need,the impact of modulating whole-body and intracellular metabolism in preclinical models and in human patients,on disease pathogenesis,have been explored.There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex,microbiome,and circadian regulation.As a major part of intracellular metabolism,mitochondrial bioenergetics,mitochondrial quality-control mechanisms,and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions.This review summarizes and highlights these efforts. | Steven N.Austad Scott Ballinger Thomas W.Buford Christy S.Carter Daniel L.Smith Jr Victor Darley-Usmar Jianhua Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 2 | Mitochon drial integrity and function in atherogenesis显示文摘 | Ballinger S Patterson C Knight-Lozano CA | 2002 | Circulation2002，106，： | 1 |
| 3 | The control of protein synthyesis during best shock in Drosophila cells involves altered polypeptide elongation rates显示文摘 | Ballinger D G | 1983 | Cell1983，33，： | 1 |
| 4 | Differential binding energy : A detailed evaluation of the influence of hydrogen - bonding and hydrophobic groups on the inhibition of thermolysin by phosphorus - containing inhibitors 显示文摘 | Morgan B P Scholtz J M Ballinger M D | 1991 | J Am Chem Soc1991，113，1： | 1 |
| 5 | Determination of chemical- oxygen demand of wastewaters without the use of mercury salts 显示文摘 | Ballinger D Lloyd A Morrish A | 1982 | Analyst1982，107，： | 1 |
| 6 | Mitochondrial dysfunction in cardiovascular disease 显示文摘 | Ballinger SW | 2005 | Free Radic Biol Med2005，38，10： | 1 |
| 7 | Total quality management and continuous quality improvement: An introduction for surgeons 显示文摘 | Ballinger W Hepner JO | 1993 | Surgery1993，113，3： | 1 |
| 8 | Octreotide in the treatment of intesti- nal lymphangiectasia显示文摘 | Ballinger AB Farthing MJ | 1998 | Eur J Gastroenterol Hepatol1998，10，8： | 1 |
| 9 | Resoluton of gumma withsteroid therapy显示文摘 | FLEET W S WATSON R T BALLINGER W E | 1986 | Neurology1986，36，8： | 1 |
| 10 | Tuberculosis and HIV co-infection:a practical therapeutic approach显示文摘 | Breen RA Swaden L Ballinger J | 2006 | Drugs2006，66，18： | 1 |
| 11 | Pharmacokinetics and hepatic disposition of bis 5-acetylamino-2,4,6-triiodoisophthalate in rats and isolated perfused rat livers显示文摘 | Liu Y Bacon ER Ballinger K | 2000 | Drug Metab Dispos2000，7，： | 1 |
| 12 | Metall Trans显示文摘 | Turnbull A Ballinger R G Hwang I S Morra M M Psailadombrowsik M Gates R M | 1992 | 23A: 32311992，23，： | 1 |
| 13 | Orlistat: its current status as ananti-obesity drug显示文摘 | BALLINGER A PEIKIN SR | 2002 | Eur J Pharmacol2002，440，23： | 1 |
| 14 | Orlistat:its current status as an antiobesity drug 显示文摘 | Peikin R S | 2002 | Eur J Pharm2002，440，23： | 1 |
| 15 | Age-related changes in D2 receptor binding with iodine-123-iodobenzofuran SPECT显示文摘 | Ichise M Ballinger JR Tanaka F | 1998 | J Nucl Med1998，39，9： | 1 |
| 16 | Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneu monia显示文摘 | Bhan U Ballinger MN Zeng X | 2010 | PloSOne2010，5，3： | 1 |
| 17 | Orlistat: its current status as an anti-obesity drug显示文摘 | Ballinger A Peikin SR | 2002 | Euro J Pharmacol2002，440，23： | 1 |
| 18 | Cathelicidin- related antimicrobial peptide is required for effective lung mucosal immunity in gram-negative bacterial pneumonia 显示文摘 | Kovach MA Ballinger MN Newstead MW | 2012 | J Immunol2012，189，1： | 1 |
| 19 | Blackleg disease on oilseed brassica in Australia: a review 显示文摘 | Salisbury P A Ballinger D J Wratten N | 1995 | Austr J Exp Agrc1995，35，： | 1 |
| 20 | Hydrogen peroxide and peroxynitrite induced mito chondrial DNA damage and dysfunction invascular endothelial and smooth muscle cells显示文摘 | Ballinger SW Patterson C Yan CN | 2000 | Circ Res2000，86，9： | 1 |
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