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您的检索式：作者名="Ballesteros LE"
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| 1 | A direct anatomical study of addition- al renal arteries in a Colombian mestizo population 显示文摘 | Saldarriaga B P~rez AF Ballesteros LE | 2008 | Folia Morphol (Warsz)2008，67，2： | 1 |
| 2 | Morphological Ex- pression of the Renal Artery: A Direct Anatomical Study in a Colombian Half-caste Population显示文摘 | Saldarriaga B Pinto SA Ballesteros LE | 2008 | Int J Morphol2008，1，26： | 1 |
| 3 | Allicin neuroprotective effect during oxidative/inflammatory injury involves AT1-Hsp70-iNOS counterbalance axis显示文摘The ancestral cultures have described many therapeutic properties of garlic,therefore,it is of central interest to elucidate the molecular basis explaining this millenary empirical knowledge.Indeed,it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic-linked to oxidative-inflammatory modulation.Allicin improved neuronal injury by heat shock protein 70(Hsp70)and inducible nitric oxide synthase(iNOS)regulation.Also,allicin exerts renal protection involving a possible angiotensin type 1 receptor(AT1)interaction.In connection,AT1 overexpression has been recognized as a central deleterious factor in many brain diseases.However,there are no studies that evaluate AT1-Hsp70-iNOS interaction as a mechanism linked to neuroinflammation.Thus,our central aim is to evaluate if the allicin protective effect is associated with an AT1-Hsp70-iNOS counterbalance axis.For this study,a murine microglial cell line(BV-2)was injured with lipopolysaccharides and treated or not with allicin.Then,it was evaluated cell viability,proinflammatory cytokine levels,cellular oxidative stress,iNOS,Hsp70,and AT1 protein expression(cellular and mitochondrial fractions),nitrite levels,and protein-protein interactions.The results demonstrated that allicin could prevent neuronal injury due to a reduction in oxidative stress and inflammatory status mediated by an AT1-Hsp70-iNOS counterbalance axis linked to direct protein-protein interaction. | LUCIANA MAZZEI MARÍA BELÉN RUIZ-ROSO NATALIA DE LAS HERAS SANDRA BALLESTEROS CAROLINA TORRESPALAZZOLO LEÓN FERDER ALEJANDRA BEATRIZ CAMARGO WALTER MANUCHA | 2020 | BIOCELL2020，44，4： | 0 |
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