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6篇 您的检索式:作者名="Back JI"
    题名 作者 年代 出处 被引量
1Physician-assisted suicide and euthanasia in Washington State:Patient requests and physician responses显示文摘Back AL Wallace JI Starks HE 1996J Am Med Assoc1996,275,:1
2Genetic analysis of auditory neuropathy spectrum disorder in the Korean population显示文摘Bae SH Back JI Lee JD 2013Gene2013,522,1:1
3The Performance Comparison of FSK, BPSK, DPSK in Underwater Communication Channel显示文摘Park Ji Hyun Back Seung-Kwan Ro Young-Ju Yoon Jong Rak 2005The Acoustical Society of Korea2005,1,:1
4Radiofrequency ablation is a thyroid function-preserving treatment for patients with bilateral be- nign thyroid nodules显示文摘Ji Hong M Back JH Choi YJ 2015J Vasc Interv Radiol2015,26,1:1
5Arthroscopic reduction and internal fixation of acetabular Frac- tures 显示文摘Hyangkyoung Kim Ji - Hoon Back Sang - Min Park 2014Knee Surg Sports Traumatol Arthmsc2014,22,:1
6Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer显示文摘Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment resistance.In particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor microenvironment.As a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages.Exosomes derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion efficiency.Reprogrammed M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the tumor.Strikingly,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.Hyosuk Kim Hyun-Ju Park Hyo Won Chang Ji Hyun Back Su Jin Lee Yae Eun Park Eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon Ji Eun Lee Yoon Se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim 2023Bioactive Materials2023,,7:0
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