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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | The potential role of resistin in atherogenesis 显示文摘 | BURNETT M S LEE C W KINNAIRD T D | 2005 | Atherosclerosis2005，182，： | 1 |
| 3 | Lung cancer,cardiopulmonary mortality and long-term exposure to fineparticulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American MedicalAssociation2002，287，9： | 1 |
| 4 | Extremely high multiplicities in high-energy nucleus-nucleus collisions显示文摘 | Burnett T H Dake S Fuki M | 1983 | Phys Rev Lett1983，50，26： | 1 |
| 5 | Lung cancer, cardiopulmonary mortality, and long-term exposure to fine par- ticulate air pollution显示文摘 | POPE I A BURNETT R T THUN M J | 2002 | American Medicine Association2002，287，9： | 1 |
| 6 | Lung cancer,cardiopulmonary mortality,and long-term exposure to fine particulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American Medical Association2002，287，9： | 1 |
| 7 | Lung cancer,cardiopulmonary mortality,and long-term exposure to fine par-ticulate air pollution显示文摘 | Pope C A 3rd Burnett R T Thun M J | | 0，，： | 1 |
| 8 | Long-term ozone exposure and mortality显示文摘 | JERRETT M BURNETT R T ARDEN C A 3rd | 2009 | N Engl J Med2009，360，111： | 1 |
| 9 | Lung cancer, cardiopulmonar mortality, and long-term exposure to fine particulate air pollution显示文摘 | Pope C A Burnett R T Thun M I | 2002 | JAMA2002，287，9： | 1 |
| 10 | Synchronized phasor measurements of a power system event显示文摘 | Burnett R O Butts M M Cease T W | 1994 | IEEE Trans on Power Systems1994，9，3： | 1 |
| 11 | Lung cancer, eardiopulmonary mortality, and long-term exposure to fine particulate air pollution 显示文摘 | POPE C A BURNETT R T THUN M J | 2002 | Jama-Joumal of the American Medical Association2002，287，9： | 1 |
| 12 | Extended follow-up and apatial analysis of the American Cancer Society study linking particulate air pollution and mortality显示文摘 | KREWSKI D JERRETT M BURNETT R T | | 0，，140： | 1 |
| 13 | Lung cancer cardiopulmonary mortality and long term exposure to fine particulate air pollution显示文摘 | POPE C A Ⅲ BURNETT R T THUN M J | | 0，，09： | 1 |
| 14 | Long-term exposure to ambient air pollution and risk of hospitalizationwith community-acquired pneumonia in older adults显示文摘 | Neupane B Jerrett M Burnett R Marrie T Arain A Loeb M | 2010 | Am J Re-spirCrit Care Med2010，181，1： | 1 |
| 15 | Lung cancer,cardiopulmonary mortality,and long-term exposure to fine particulate air pollution显示文摘 | Burnett R T Thun M J | 2002 | JAMA2002，287，9： | 1 |
| 16 | Lung cancer,cardiopulmonary mortality, and long-terra exposure to fine partieulateair pollution 显示文摘 | POPE C A 3rd BURNETT R T THUN M J | 2002 | JAMA2002，287，9： | 1 |
| 17 | Anticipation of Ac- tion Intentions in Autism Spectrum Disorder显示文摘 | Hudson M Burnett HG Jellema T | 2012 | Jour- nal Autism and Developmental Disorders2012，42，8： | 1 |
| 18 | Synchronized phasor measurements of a power system event显示文摘 | BURNETT R O BUTTS M M CEASE T W | 1994 | IEEE Transactions on Power Systems1994，9，3： | 1 |
| 19 | Marrow-derlved stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms显示文摘 | Kinnaird T Stabile E Burnett M S | 2004 | Circ Res2004，94，5： | 1 |
| 20 | A GIS-environmental justice analysis of particulate air pollution inHamilton, Canada显示文摘 | JERRETT M BURNETT R T | 2001 | Environ Plann A2001，33，： | 1 |
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