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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | Lung cancer,cardiopulmonary mortality and long-term exposure to fineparticulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American MedicalAssociation2002，287，9： | 1 |
| 3 | Short-term clinical effects of tolvaptan,an oral vasopressin antagonist,in patients hospitalized for heart failure:the EVEREST Clinical Status Trials显示文摘 | Gheorghiade M Konstam M A Burnett J J | 2007 | JAMA2007，297，12： | 1 |
| 4 | Support for investigator-initiated clinical research involving investigational drugs or devices:the clinical and translational science award experience显示文摘 | Berro M Burnett BK Fromell J | | 0，，02： | 1 |
| 5 | Cross-sectional associations of resistin, coro nary heart disease, and insulin resistance显示文摘 | BURNETT M S DEVANEY J M ADENIKA R J | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 6 | Lung cancer, cardiopulmonary mortality, and long-term exposure to fine par- ticulate air pollution显示文摘 | POPE I A BURNETT R T THUN M J | 2002 | American Medicine Association2002，287，9： | 1 |
| 7 | Vitamin E in human health and disease显示文摘 | Clarke M W Burnett J R Croft K D | 2008 | Critical Reviews in Clinical Laboratory Sciences2008，45，5： | 1 |
| 8 | Associations between abortion, mental disorders, and suicidal behavior in a nationally representative sample 显示文摘 | Mota N P Burnett M Sareen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 9 | Lung cancer,cardiopulmonary mortality,and long-term exposure to fine particulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American Medical Association2002，287，9： | 1 |
| 10 | Lung cancer,cardiopulmonary mortality,and long-term exposure to fine par-ticulate air pollution显示文摘 | Pope C A 3rd Burnett R T Thun M J | | 0，，： | 1 |
| 11 | Associations between abor- tion,mental disorders, and suicidal behaviour in a nationally representative sample 显示文摘 | Mota NP Burnett M Sareen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 12 | Cytochrome P450 is the primary enzyme responsible for lowdose carbon tetrachloride metabolism in human liver microsome显示文摘 | Zangar RC Benson J M Burnett VL | 2000 | Chem Biol Interact2000，125，3： | 1 |
| 13 | Real-Time Bose-Einstein condensationin a finite volume with a discrete spectrum 显示文摘 | RUPRECHT P A HOLLAND M J BURNETT K | 1995 | Ibid1995，51，3： | 1 |
| 14 | Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocatiens 显示文摘 | Thirman M J Gill H J Burnett R C | 1993 | New Engl J Med1993，329，： | 1 |
| 15 | Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution 显示文摘 | Pope CA Burnett RT Thun M J | 2002 | JAMA2002，287，9： | 1 |
| 16 | Lung cancer, eardiopulmonary mortality, and long-term exposure to fine particulate air pollution 显示文摘 | POPE C A BURNETT R T THUN M J | 2002 | Jama-Joumal of the American Medical Association2002，287，9： | 1 |
| 17 | Lung cancer cardiopulmonary mortality and long term exposure to fine particulate air pollution显示文摘 | POPE C A Ⅲ BURNETT R T THUN M J | | 0，，09： | 1 |
| 18 | Adenovirus structure 显示文摘 | Rux J J Burnett R M | 2004 | Hum gene ther2004，15，12： | 1 |
| 19 | Associations between abortion, mental disorders, and suicidal behavior in a nationally repre- sentative sample显示文摘 | Morn NP Burnett M Sateen J | 2010 | Can J Psychiatry2010，55，4： | 1 |
| 20 | Natriuretic peptides in cardiovascular diseases:current use and perspectives显示文摘 | Volpe M Rubattu S Burnett J | 2014 | Eur Heart J2014，35，7： | 1 |
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