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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | The potential role of resistin in atherogenesis 显示文摘 | BURNETT M S LEE C W KINNAIRD T D | 2005 | Atherosclerosis2005，182，： | 1 |
| 3 | Lung cancer,cardiopulmonary mortality and long-term exposure to fineparticulate air pollution显示文摘 | Pope C A Burnett R T Thun M J | 2002 | Journal of the American MedicalAssociation2002，287，9： | 1 |
| 4 | Pathophysiology of peripheral nerve injury:a brief review显示文摘 | Burnett M G Zager E L | 2004 | Neurosurg Focus2004，16，5： | 1 |
| 5 | Adrenomedullin: potential in physiology and pathophysiology显示文摘 | Jougasaki M Burnett JC | 2000 | Life Sci2000，66，10： | 1 |
| 6 | Short-term clinical effects of tolvaptan,an oral vasopressin antagonist,in patients hospitalized for heart failure:the EVEREST Clinical Status Trials显示文摘 | Gheorghiade M Konstam M A Burnett J J | 2007 | JAMA2007，297，12： | 1 |
| 7 | Short term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials显示文摘 | Gheorghiade M Konstam MA Burnett JC Jr | 2007 | JAMA2007，297，12： | 1 |
| 8 | Conceptualizing guilt in the consumer decision-making process 显示文摘 | Burnett M S Lundford D A | 1994 | Consum Mark1994，11，3： | 1 |
| 9 | Activities,context and ubiquitous computing显示文摘 | Prekop P Burnett M | 2003 | Computer Communications2003，26，： | 1 |
| 10 | Activation of EphA2kinase suppresses integrin function and causes focal-adhesion kinase dephosphorylation 显示文摘 | Miao H Burnett E Kinch M | 2000 | Nat Cell Biol2000，2，2： | 1 |
| 11 | Support for investigator-initiated clinical research involving investigational drugs or devices:the clinical and translational science award experience显示文摘 | Berro M Burnett BK Fromell J | | 0，，02： | 1 |
| 12 | Short term clinical effects of tolvaptan,an oral vasopressin antagonist,in patients hospitalized for heart failure: results of the EVEREST clinical status trials显示文摘 | Gheorghiade M Konstam MA Burnett JC | 2007 | JAMA2007，297，12： | 1 |
| 13 | Cross-sectional associations of resistin, coro nary heart disease, and insulin resistance显示文摘 | BURNETT M S DEVANEY J M ADENIKA R J | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 14 | Posterior-stabilized versus cruciate-retaining total knee arthroplasty : balancing the gap 显示文摘 | Tanzer M Smith K Burnett S | 2002 | J Arthroplasty2002，7，： | 1 |
| 15 | Effects of oral tolvaptan in patients hospitalized for worsening heart {ailure: the EVEREST Outcome Trial显示文摘 | Gheorghiade M Konstam MA Burnett JC Jr | 2007 | JAMA2007，297，12： | 1 |
| 16 | Extremely high multiplicities in high-energy nucleus-nucleus collisions显示文摘 | Burnett T H Dake S Fuki M | 1983 | Phys Rev Lett1983，50，26： | 1 |
| 17 | Theeffect of hypercapnic hypoxia on the survival of shrimpchallenged with Vibrio parahaemolyticus显示文摘 | MIKULSKI C M BURNETT L E BURNETT K G | 2000 | Shellfish Res2000，19，： | 1 |
| 18 | Lung cancer, cardiopulmonary mortality, and long-term exposure to fine par- ticulate air pollution显示文摘 | POPE I A BURNETT R T THUN M J | 2002 | American Medicine Association2002，287，9： | 1 |
| 19 | Static type inference for a first-order declarative显示文摘 | Djang R Burnett M M Chen R D | 2000 | Journal of Visual Languages and Computing2000，1，： | 1 |
| 20 | Regulation of cterminaland intact FGF-23 by dietary phosphatein men and women显示文摘 | Burnett S A M Gunawardene S C Bringhurst F R | 2006 | Journal of Bone and mineral Research2006，21，8： | 1 |
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