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| 1 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 2 | Assessing indicators of agricultural drought impacts on spring wheat yield and quality on the Canadian prairies显示文摘 | Mkhabela M Bullock P Gervais M | 2010 | Agricultural and Forest Meteorology2010，150，3： | 1 |
| 3 | Molecular and cellular mechanisms in the pathophysiology of severe head injury显示文摘 | Enriquez P Bullock R | 2004 | Curr Pharm Des2004，10，18： | 1 |
| 4 | Variable Speed Limits: Safety and Operational Impacts of a Candidate Control Strategy for Freeway Applications 显示文摘 | ALLABY P HELLINGA B BULLOCK M | 2006 | IEEE Transactions on Intelligent Transportation Systems2006，8，4： | 1 |
| 5 | Ago-ecological characterisation, food production and security显示文摘 | Bullock P | 1997 | Developments in Crop Science1997，25，： | 1 |
| 6 | Time-evolution of the GaAs(001)pre-roughening process显示文摘 | DING Z BULLOCK D W THIBADO P M | 2003 | Surface Science2003，540，23： | 1 |
| 7 | Endopolyploidization of mesoeotyls in Nebraska maize populations selected for cold tolerance 显示文摘 | Wilhelm E d Biradar D P Bullock D G | 1995 | Crop Science1995，35，： | 1 |
| 8 | Detecting staphylococcal enterotoxin B using an automated fiber optic biosensor显示文摘 | King K D Anderson G P Bullock K E | 1999 | Biosensor & Bioelectronics1999，14，： | 1 |
| 9 | Soft TQM, hard TQM, and organizational performance relationships: an empirical in- vestigation显示文摘 | RAHMAN S BULLOCK P | 2005 | The International Journal of Management Science2005，33，： | 1 |
| 10 | Improving Steel Cleanliness Through Tundish Baffle Technology显示文摘 | SUZWKI Y BULLOCK R A | 1991 | I&SM1991，，8： | 1 |
| 11 | Deriving tree diameter distributions using Bayesian model averaging显示文摘 | Bullock B P Boone E L | 2007 | Forest Ecology and Management2007，242，： | 1 |
| 12 | Integration of image guidance and rapid prototyping technology in craniofacial surgery显示文摘 | Bullock P Dunaway D Mcgurk L | 2013 | lnt J Oral Max Surg2013，42，： | 1 |
| 13 | Atomic structure of the GaAs(001)-(2x4) surface resolved using scanning tunneling microscopy and first-principles theory显示文摘 | LaBella V P Yang H Bullock D W | 1999 | Physical Review Letters1999，83，15： | 1 |
| 14 | Changes in early acoustic-evoked potentials by mildly arousing priming stimuli in carp (Cyprinus carpio)显示文摘 | Laming P R Bullock T H | 1991 | Comp Biochem Physiol1991，99，： | 1 |
| 15 | Variable Speed Limits Safety and Operational Impacts of a Candidate Control Strategy for Freeway Applications 显示文摘 | ALLABY P HELLINGA B BULLOCK M | 2006 | IEEE Transactions on Intelligent Transportation Systems (S 1524-9050)2006，8，4： | 1 |
| 16 | Correlation between aminoacid release and neuropathologic outcome in rat brain follo ing middle cerebral artery occlusion显示文摘 | BUTCHER S P BULLOCK R GRAHAM D | 1990 | Stroke1990，21，12： | 1 |
| 17 | Service Quality - developing a Service Quality Index in the Provision of Commercial Bus Contracts 显示文摘 | Hensher D Stopher P Bullock P | 2003 | Transportation Research Part A2003，37，： | 1 |
| 18 | Assessing indicators of agricultural drought impacts on spring wheat yield and quality on the Canadian prairies显示文摘 | Mkhabela M Bullock P Gervais M | 2010 | Agricultural and Forest Meteorology2010，150，3： | 1 |
| 19 | 6-(Alkylamino)-9-alkylpurines: A New Class of Potential Antipsychotic Agents显示文摘 | KELLEY J L BULLOCK R M KROCHMAL M P et ol | 1997 | J Med Chem1997，40，： | 1 |
| 20 | Spatially resolved spin-injection probability for gallium arsenide显示文摘 | LaBELLA V P BULLOCK D W DING Z | 2001 | Science2001，292，： | 1 |
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