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| 1 | 关于沉降物中汞来源的进展和不确定性的综合分析显示文摘作为第八届全球污染物汞问题国际会议的一部分,一组国际汞问题专家于2005年在威斯康星的麦迪逊召开会议。会议的任务是讨论汞来源的科学依据研究现状。具体讲我们的关键问题是:对某一个指定地点,我们是否有把握确定局地、区域和全球的汞来源的相对份额,自然的相对于人为因素的汞排放和沉降。专家组综合分析了在过去10年来所发表的关于这个问题的最新研究情况,重点在以下4个主要研究课题:长期的人类活动影响的变化,当前的排放和沉降趋势,化学转换与循环,模拟与不确定性。在每一个课题中,专家组都得出一系列的结论,本文对此进行了描述。这些结论同时使得我们对问题的回答是'性质上是',而这种资格取决于所愿意接受的不确定性水平。我们同意这种不确定性主要取决于尺度,以及我们所提出的问题在位于主要点源很近和很远的地方均可得到比较有信心的回答,假设'全球汞库'是被承认的'来源'。从生态系统暴露这个角度来看,很多感兴趣的区域则处于中间地带,带有最大程度的不确定性。 | Steve Lindberg Russell Bullock Ralf Ebinghaus Daniel Engstrom 冯新斌 William Fitzgerald Nicola Pirrone Eric Prestbo Christian Seigneur 赵绪才(译) | 2007 | AMBIO-人类环境杂志2007，36，1： | 13 |
| 2 | The effect of surface roughness on claw and adhesive hair performance in the dock beetle Gastrophysa viridula显示文摘自然粘合剂系统被改编属于不平的表面,而是内在的机制充分没被澄清。为甲壳虫 Gastrophysa viridula 的附件力量用一台离心机设备与不同粗糙在表面的环氧基树脂演员组上被记录。复制品用擦亮纸标准化,粗糙尺寸从 0.05 ~ 30 m 并且船坞叶子(Rumex obtusifolius )做的。甲壳虫在光滑的底层上或在他们的主人植物的叶子的演员组上与多达 36 次身体重量的一个安全因素粘住。在不平的底层上,力量在小规模粗糙是更低的大部分和最小(0.05 m 粗糙尺寸,与 5 的一个吝啬的安全因素) 被观察。爪的移动与粗糙尺寸为不平的底层在力量导致了重要减小 12 m。毛乎乎的粘合剂系统本身的附件力量(没有爪) 稍微增加了从对大规模表面粗糙小规模,但是在在光滑的底层上看见的水平下面留下了。这被 setal 尖端的无能解释做完整的接触到表面。 | James M. R. Bullock Walter Federle | 2011 | Insect Science2011，18，3： | 6 |
| 3 | Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells显示文摘Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults.Current therapy includes surgery,radiation and chemotherapy with temozolomide (TMZ).Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter and mismatch repair (MMR) status.Though the MGMT promoter is methylated in 45% of cases,for the first nine months of follow-up,TMZ does not change survival outcome.Furthermore,MMR deficiency makes little contribution to clinical resistance,suggesting that there exist unrecognized mechanisms of resistance.We generated paired GBM cell lines whose resistance was attributed to neither MGMT nor MMR.We show that,responding to TMZ,these cells exhibit a decoupling of DNA damage response (DDR) from ongoing DNA damages.They display methylation-resistant synthesis in which ongoing DNA synthesis is not inhibited.They are also defective in the activation of the S and G2 phase checkpoint.DDR proteins ATM,Chk2,MDC1,NBS1 and gammaH2AX also fail to form discrete foci.These results demonstrate that failure of DDR may play an active role in chemoresistance to TMZ.DNA damages by TMZ are repaired by MMR proteins in a futile,reiterative process,which activates DDR signaling network that ultimately leads to the onset of cell death.GBM cells may survive genetic insults in the absence of DDR.We anticipate that our findings will lead to more studies that seek to further define the role of DDR in ultimately determining the fate of a tumor cell in response to TMZ and other DNA methylators. | Stewart P.Johnson Nancy Bullock Francis Ali Osman Darell D.Bigner Henry S.Friedman | 2010 | The Journal of Biomedical Research2010，24，6： | 6 |
| 4 | A comparative study of interpolation methods for mapping soil properties显示文摘 | Kravchenko A Bullock D G | 1999 | Agronomy Journal1999，91，3： | 2 |
| 5 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 6 | Batteries,1977 to 2002 显示文摘 | BRODD R J BULLOCK KR | 2004 | J Electrochem Soc2004，151，3： | 1 |
| 7 | Carbon reactions and effects on valve-regulated lead-acid (VRLA) battery cycle life in high-rate,partial state-of- charge cycling 显示文摘 | BULLOCK K R | 2010 | J Power Sources2010，195，14： | 1 |
| 8 | Testicular microlithiasis US follow-up显示文摘 | Bennett H F Middleton W D Bullock A D | 2001 | Radiogy2001，218，2： | 1 |
| 9 | Wind erosion effects on nutrient redistribution and soil productivity显示文摘 | Francis J Larney Murray S Bullock H Henry Janzen | 1998 | Journal of Soil and Water Conservation1998，53，2： | 1 |
| 10 | Colonization of grassland by sown species: dispersal versus microsite limitation in responses to management显示文摘 | Coulson S J Bullock J M & Stevenson M J | 2001 | Journal of Applied Ecology2001，38，： | 1 |
| 11 | Assessing indicators of agricultural drought impacts on spring wheat yield and quality on the Canadian prairies显示文摘 | Mkhabela M Bullock P Gervais M | 2010 | Agricultural and Forest Meteorology2010，150，3： | 1 |
| 12 | Long distance seed dispersal by wind:measuring and modelling the tail of the curve显示文摘 | Clarke R T | 2000 | Oecologia2000，124，4： | 1 |
| 13 | Molecular and cellular mechanisms in the pathophysiology of severe head injury显示文摘 | Enriquez P Bullock R | 2004 | Curr Pharm Des2004，10，18： | 1 |
| 14 | The neurotrophic protein S100B : value as a marker of brain damage and possible therapeutic implications 显示文摘 | Kleindienst A Hesse F Bullock MR | 2007 | Piog Brain Res2007，161，1： | 1 |
| 15 | Induction of CD70 on dendritic cells through C040 or TLR stimulation contributes to the development of CD8 + T cell responses in the absence of C04 + T cells 显示文摘 | Bullock TN Yagita H | 2005 | J Immunol2005，174，2： | 1 |
| 16 | Current and future role of ther- apeutic hypothermia 显示文摘 | Marion D Bullock M R | 2009 | J Neurotrauma2009，26，3： | 1 |
| 17 | Intracranial pressure monitoring for traumatic brain injury in the modern era显示文摘 | Padayachy LC Figaji AA Bullock MR | 2010 | Childs Nerv Syst2010，26，4： | 1 |
| 18 | Variable speed limits, safety and operation impacts of a candidate control strate- gy for freeway applieations显示文摘 | AllabyP Hellinga B Bullock M | 2007 | IEEE Transaction on Intel- ligent Transportation Systems2007，8，4： | 1 |
| 19 | The neurotrophic protein S100B: value as a marker of brain damage and possible therapeutic implications 显示文摘 | Kleindienst A Hesse F Bullock MR | 2007 | Prog Brain Res2007，161，12： | 1 |
| 20 | Museuloskeletal injuries: description of an under-recognized injury problem among military personnel 显示文摘 | Hauret K G Jones B H Bullock S H | 2010 | American journal of preventive medicine2010，38，1： | 1 |
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