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	题名	作者	年代	出处	被引量
1	Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.	C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf	2014	World Journal of Cardiology2014，6，4：	3
2	Multivariate statistical modeling for image denoising using wavelet transforms显示文摘	Cho D Bui T D	2005	Signal Processing:Image Communication2005，20，：	1
3	Translation-invm'iant denoising using muhiwavelets 显示文摘	BUI T D CHEN Guang-yi	1998	IEEE Trans on Signal Processing1998，46，12：	1
4	Translation-invariant de-noising using multiwavelets显示文摘	BUI T D CHEN G Y	1998	IEEE Transaction on Signal Processing1998，46，12：	1
5	Multivariate Statistical Modeling for Image Denoising Using Wavelet Transforms显示文摘	Dongwook Cho Tien D Bui	2005	Signal Processing:Image Communication2005，20，：	1
6	Landslide suscepti- bility analysis in the Hoa Binh province of Viemam using statistical index and logistic regression显示文摘	Bui D T Lofman O Revhaug I	2011	Natural Haz- ards2011，59，3：	1
7	Land slide suscep- tibility analysis in the Hoa Binh province of Vietnam using statistical index and logistic regression显示文摘	BUI D T LOFMAN O REVHAUG I	2011	Natural Hazards2011，59，3：	1
8	Technique for measurement of power-line impedance in the frequency range from 500 kHz to 500 MHz 显示文摘	Kwasniok P J Bui M D Kozlowski A J	1993	IEEE Trans on Electromagnetic Compatibility1993，35，1：	1
9	Propagation of transients in dispersive dielectric media显示文摘	Stuchly S S Costache G I	1991	IEEE Trans MTT1991，39，7：	1
10	Functional scintigraphy of the adrenal gland显示文摘	Rubello D Bui C Casara D	2002	Eur J Endocrinol2002，147，1：	1
11	Solving Stiff Differential Equation in the Simulation of Physical Systems显示文摘	Tien D Bui	1990	Simulation1990，54，5：	1
12	Rotation invariant pattern recognition using ridgelet, wavelet cycle-spinning, and fourier features 显示文摘	Chen G Y Bui T D Krzyzak A	2005	Pattern Recognition2005，38，12：	1
13	Translation-invariant denoising using multiwavelets 显示文摘	Bui T D Chen G	1998	IEEE Trans SP1998，46，12：	1
14	Numerical Modeling of Bed Deformation in Laboratory Channels显示文摘	BUI M D THOMAS W N WOLFGANG R	2004	Journal of Hydraulic Engineering2004，130，9：	1
15	Multivariate statistical modeling for image denoising using wavelet transforms显示文摘	Dongwook Cho Tien D Bui	2005	Signal Processing:Image Communication2005，20，：	1
16	Genetic reductionof group 1 metabotropic glutamate receptors altersselect behaviors in a mouse model for fragile X syndrome显示文摘	THOMAS AM BUI N GRAHAM D	2011	Behav Brain Res2011，223，2：	1
17	Image denoising with neighbour dependency and customized wavelet and threshold显示文摘	CHEN G Y BUI T D KRZYAK A	2005	Pattern Recognition2005，38，1：	1
18	Comparison of CT and catheter arteriography for evaluation of peripheral arterial disease 显示文摘	Bui TD Gelfand D Whipple S	2005	Vase Endovaseular Surg2005，39，6：	1
19	Predictors of morbidity and mortality in patients with traumatic duodenal injuries显示文摘	Huerta S Bui T Porral D	2005	Am Surg2005，71，9：	1
20	Rotation invariant texture classification by ridgelet transform and frequency- orientation space decomposition 显示文摘	Pan W Bui T D Suen C Y	2008	Signal Processing2008，88，：	1

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