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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | White light generation by frequency upconversionin Tm^3+/Ho^3+/ Yb^3+ -codoped fluorolead germanate glass显示文摘 | Gouveia-Neto L A Bueno R F do Nascimento | 2007 | Appl Phys Lett2007，91，09： | 1 |
| 3 | Phase Ⅰ to Ⅱ study of pleureetomy/desortication and intraoparative intracavitary hyperthermic cisplatin lavage for mesothelioma显示文摘 | Bichards WG Zellos L Bueno R | 2006 | J Clin Oncol2006，24，： | 1 |
| 4 | Altered protease signalling in the gut: a novel pathophysiological factor in irritable bowel syndrome 显示文摘 | Roka R Wittmann T Bueno L | 2008 | Neurogastroenterol Motil2008，20，8： | 1 |
| 5 | Effect of the addition of ZnO seeds on the electrical properties of ZnO-based varistors显示文摘 | Souza F L Gomes J W Bueno P R | 2003 | Mater Chem Phys2003，80，： | 1 |
| 6 | White Light Generation by Frequency Upconversion in Tm^3+/Ho^3+/Yb^3+-codoped Fluorolead Germanate Glass显示文摘 | Gouveia-Neto A S Bueno L A Nascimento do R F | 2007 | Appl Phys Lett2007，91，09： | 1 |
| 7 | Sol-gel nonhydrolytic synthesis of a hybrid organic-inorganic electrolyte for application in lithium-ion devices显示文摘 | SOUZA F L BUENO P R LONGO E LEITE E R | 2004 | Solid State Ionics2004，3，7： | 1 |
| 8 | Yield and soil fertility trends in a 20-year rice-rice-wheat experiment in Nepal显示文摘 | Regmi A P Ladha J K Pathak H Pasuquin E Bueno C Dawe D Hobbs P R Joshy D Maskey S L Pandey S P | 2002 | Soil Sei Soc Am J2002，66，： | 1 |
| 9 | White light generation by frequency upeonversion in Tm3+/Ho3+ / Yb3+-codoped fluorolead germanate glass 显示文摘 | Gouveia-Neto A S Bueno L A Nascimento R F | 2007 | Appl Phys Lett2007，91，09： | 1 |
| 10 | 2014, Influence of fish farming in net cages on phytoplankton structure: a case study in a subtropical Brazilian reservoir 显示文摘 | BARTOZEK E C R BUENO N C RODRIGUES L C | 2014 | Brazilian Journal of Biology2014，74，1： | 1 |
| 11 | Experimental rat model for fetal growth restriction:effects on liver glycogen and intestinal and renal morphometry显示文摘 | Bueno M P Barini R Gonalves F L | 2010 | Rev Bras Ginecol Obstet2010，32，4： | 1 |
| 12 | Gene-ralized st- numbering for simply connected graphs 显示文摘 | BUENO L R HAUSEN R MENDONCA C F X | 2011 | Simposio Brasileiro de Pesquisa Operacional2011，，： | 1 |
| 13 | Lungresection in patients with preoperative FEV1 显示文摘 | UNDEN P A BUENO R COLSON Y L | 2005 | Chest2005，127，6： | 1 |
| 14 | Pesticide selectivity for the insect egg parasitoid Telenomus remus显示文摘 | CARMO E L BUENO A F BUENO R C O F | 2010 | BioControl2010，55，4： | 1 |
| 15 | Low-voltage varistor based on (Sn, Ti)O2 ceramics显示文摘 | BUENO P R CASSIA-SANTOS M R SIM?ES L G P GOMES J W LONGO E VARELAJ A | 2002 | J Am Ceram Soc2002，85，1： | 1 |
| 16 | Filamentous fungi preservation in distilled water显示文摘 | Bueno L Gallardo R | 1998 | Rev Iberoam Micol1998，15，3： | 1 |
| 17 | Bayesian mapping of multiple traits in maize: The importance of pleiotropic effects in studying the inheritance of quantitative traits显示文摘 | Balestre M Von Pinho R G de Souza Junior C L de Sousa Bueno Filho J S | 2012 | Theoretical and Applied Genetics2012，125，3： | 1 |
| 18 | Sol-gel nonhydrolytic synthesis of a hybrid organic-inorganic electrolyte for application in lithium-ion devices显示文摘 | Souza F L Bueno P R Longo E | 2004 | Solid State Ionics2004，166，12： | 1 |
| 19 | Sintering and mass tran sport features of (Sn,Ti)O2 polycrystalline ceramics 显示文摘 | Leite E R Bulohes L O S | 2003 | J European Ceramic Society2003，23，： | 1 |
| 20 | Differential diagnosis of apical periodontitis and nasopalatine ductcyst显示文摘 | Faitaroni L A Bueno M R Carvalhosa A A | 2011 | J Endod2011，37，3： | 1 |
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