|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure显示文摘Heart failure(HF), the number one cause of death in the western world, is caused by the insufficient performance of the heart leading to tissue underperfusion in response to an injury or insult. It comprises complex interactions between important neurohormonal mechanisms that try but ultimately fail to sustain cardiac output. The most prominent such mechanism is the sympathetic(adrenergic) nervous system(SNS), whose activity and outflow are greatly elevated in HF. SNS hyperactivity confers significant toxicity to the failing heart and markedly increases HF morbidity and mortality via excessive activation of adrenergic receptors, which are G protein-coupled receptors. Thus, ligand binding induces their coupling to heterotrimeric G proteins that transduce intracellular signals. G protein signaling is turned-off by the agonist-bound receptor phosphorylation courtesy of G protein-coupled receptor kinases(GRKs), followed by βarrestin binding, which prevents the GRK-phosphorylated receptor from further interaction with the G proteins and simultaneously leads it inside the cell(receptor sequestration). Recent evidence indicates that adrenal GRK2 and βarrestins can regulate adrenal catecholamine secretion, thereby modulating SNS activity in HF. The present review gives an account of all these studies on adrenal GRKs and βarrestins in HF and discusses the exciting new therapeutic possibilities for chronic HF offered by targeting these proteins pharmacologically. | Katie A Mc Crink Ava Brill Anastasios Lymperopoulos | 2015 | World Journal of Cardiology2015，7，9： | 4 |
| 2 | Neutrophil extracellular trap(NET)impact on deep vein thrombosis显示文摘 | Fuchs TA Brill A Wagner DD | | 0，，： | 1 |
| 3 | Platelet-derived microparticles promote invasiveness of prostate cancer cells cia upregulation of MMP-2 production显示文摘 | Dashevsky 0 Varon D Brill A | 2009 | IntJ Cancer2009，124，8： | 1 |
| 4 | Finding consensus in speech recognition: word error minimization and other applications of confusion networks显示文摘 | Mangu L Brill E and Stolcke A | 2000 | Computer Speech & Language2000，14，4： | 1 |
| 5 | Trace element contents and partitioning of elements in ore minerals from the Csa Cu - Pb - Zn deposit, Australia 显示文摘 | B A Brill | 1989 | Canadian Mineralogist1989，，27： | 1 |
| 6 | Platelets cross-talk with tumor cells显示文摘 | Brill A | 2001 | Haemostasis2001，311，： | 1 |
| 7 | Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry显示文摘 | Salomon A R Ficarro S B Brill L M | 2003 | Proc Natl Acad Sci USA2003，100，： | 1 |
| 8 | Impact of obesity on drug metabolism and elimination in adults and children显示文摘 | Brill MJ Diepstraten J van Rongen A | 2012 | Clin Pharmacokinet2012，51，5： | 1 |
| 9 | Phylogenetic relationships of West Nile viruses isolated from birds and horses in Israel from 1997 to 2001显示文摘 | Noach B C Malkinson M Brill A | 2003 | Virus Genes2003，26，2： | 1 |
| 10 | Study of two-phase flow in inclined pipes 显示文摘 | BEGGS H D BRILL J P A | 1973 | JPT1973，25，5： | 1 |
| 11 | Cervical Pregnancy:Case Report s and a Current Literature Review显示文摘 | Marcovic I Rosenzweig B A Brill A I | 1994 | ObstetGynecolsury1994，49，1： | 1 |
| 12 | ADAMTS13: a new link between thrombosis and inflammation显示文摘 | Chauhan AK Kisucka J Brill A | 2008 | J Exp Med2008，205，9： | 1 |
| 13 | An EOQ model with random variations in demand显示文摘 | BRILL P H CHAOUCH B A | 1995 | Management Science1995，41，5： | 1 |
| 14 | Mechanistic modeling of two-phase flow in deviated wells 显示文摘 | Kaya A S Sarica C Brill J P | 2001 | SPE Production and Facilities2001，16，3： | 1 |
| 15 | Neutrophil extracellular trap (NET) impact on deep vein thrombosis 显示文摘 | Fuchs TA Brill A Wagner DD | 2012 | Arterioscler Thromb Vasc Biol2012，32，8： | 1 |
| 16 | von Willebrand factorediated platelet adhesion is critical for deep vein thrombosis in mouse models显示文摘 | Brill A Fuchs TA Chauhan AK | 2011 | Blood2011，117，4： | 1 |
| 17 | ADAMTS13 : a new link between thrombosis and inflammation显示文摘 | Chauhan AK Kisucka J Brill A | 2008 | J Exp Mcd2008，205，9： | 1 |
| 18 | A comparison of the crystal structures, IR spectra, thermolysis and impact sensitivities of ni- troguanidine and trinitroethylni-roguanidine显示文摘 | Oyumi Y Rheingold A L Brill T B | 1987 | Propellants Ex- plosives Pyrotechnics1987，12，： | 1 |
| 19 | Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma显示文摘 | UGRAS S BRILL E JACOBSEN A | | 0，，17： | 1 |
| 20 | Oxidativestress activates ADAM 17/TACE and induces its target re-ceptor shedding in platelets in a p38-dependent fashion显示文摘 | BRILL A CHAUHA AK CANAULT M | 2009 | Cardiovascular research2009，84，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员