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| 1 | EULAR recom- mendations for the management of rheumatoid arthritis with syn-thetic and biological disease-modifying antirheumatic drugs 显示文摘 | Smolen JS Landewe R Breedveld FC | 2010 | Ann Rheum Dis2010，69，6： | 1 |
| 2 | Understanding emerging treatment paradigms in rheumatoid arthritis显示文摘 | Breedveld FC Combe B | 2011 | Arthritis Res Ther2011，13，1： | 1 |
| 3 | Comparison of methotrexate monotherapy with a combination of metho- trexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, doubleblind, parallel treatment trial 显示文摘 | Emery P Breedveld FC Hall S | 2008 | Lancet2008，372，9636： | 1 |
| 4 | A compa- rison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis显示文摘 | EMERY P BREEDVELD FC LEMMEL EM | 2000 | Rheumatology (Oxford)2000，39，6： | 1 |
| 5 | Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factorαmonoclonal antibody combined with lowdose weekly methotrexate in rheumatoid arthrtis 显示文摘 | Maini RN Breedveld FC Kalden JR | 1998 | Arthrtis Rheum1998，41，9： | 1 |
| 6 | Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other immune mediated inflammatory diseases显示文摘 | Breedveld FC Kalden JR | 2003 | Ann Rheum Dis2003，62，： | 1 |
| 7 | Leflunomide:mode of action in the treatment of rheumatoid arthritis 显示文摘 | Breedveld FC Dayer JM | 2000 | Ann Rheum Dis2000，59，11： | 1 |
| 8 | Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active,early,moderate to severe rheumatoid arthritis (COMET):a randomised,double-blind,parallel treatment trial显示文摘 | Emery P Breedveld FC Hall S | 2008 | Lancet2008，372，： | 1 |
| 9 | T cells in rheumatoid arthritis 显示文摘 | Breedveld FC Verweij CL | 1997 | Br J Rheumatol1997，36，6： | 1 |
| 10 | A comparison of the ef-i cacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis显示文摘 | Emery P Breedveld FC Lemmel EM | | 0，，06： | 1 |
| 11 | Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis显示文摘 | van der Helm van Mil AH Verpoort KN Breedveld FC | 2005 | Arthritis Res Ther2005，7，5： | 1 |
| 12 | The PREMIER study: a multicenter, randomized, doubleblindclinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressiverheumatoid arthritis who had not had previous methotrexate treattnent 显示文摘 | Breedveld FC Weisman MH Kavanaugh AF | 2006 | Arthritis Rheum2006，54，1： | 1 |
| 13 | New insights in the pathogenesis of rheumalohl arthritis显示文摘 | Breedveld Fc | 1998 | J Rheum1998，25，： | 1 |
| 14 | Efficacy and safety of the fully human anti-tumour necrosis factor a monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis : a 12 week, phase II study 显示文摘 | van de Putte LBA Rau R Breedveld FC | 2003 | Ann Rheum Dis2003，62，12： | 1 |
| 15 | Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007 显示文摘 | Furst DE Breedveld FC Kalden JR | 2007 | Ann Rheum Dis2007，66，3： | 1 |
| 16 | Updated consensus statement on biological agents,specifically tumor necrosis factor α (TNFαt) blocking agents and interleukin-1 receptor antagonist(IL-1ra),for the treatment of rheumatic diseases显示文摘 | FURST DE BREEDVELD FC KALDEN JR | 2005 | Ann Rheum Dis2005，，： | 1 |
| 17 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs 显示文摘 | Smolen JS Landew6 R Breedveld FC et at | 2010 | Ann Rheum Dis2010，69，6： | 1 |
| 18 | A simplified disease activity index h~r rheumatoid arthritis for use in clinical practice 显示文摘 | Smolen JS Breedveld FC Schiff MH | 2003 | Rheumatology ( Oxford)2003，42，： | 1 |
| 19 | TNF- alpha blockade and tuberculosis: better look before you leap显示文摘 | Arend SM Breedveld FC van Dissel JT | 2003 | Neth J Med2003，62，： | 1 |
| 20 | Leflunomide:mode of action in the treatment of rheumat oid arthritis显示文摘 | Breedveld FC Dayer JM | 2000 | Ann Rhearn Dis2000，59，： | 1 |
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