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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Glucagon-like peptide-1 secretion in bulimia nervosa显示文摘 | Brambilla F Monteleone P Mai M | 2009 | Psychiatry Res2009，169，1： | 1 |
| 3 | Supercontinuum generation in tapered bismuth silicate fibres显示文摘 | Brambilla G Koizumi F Finazzi V | 2005 | Electro Lett2005，41，： | 1 |
| 4 | Molecular characterization and expression analysis of Na+/H+ exchanger (NHE)-1 and c-Fos genes in sea bass (Dicentrarchus labrax, L) exposed to acute and chronic hypercapnia 显示文摘 | RIMOLDI S TEROVA G BRAMBILLA F | 2009 | Journal of Experimental Marine Biology and Ecology2009，375，12： | 1 |
| 5 | Blood levels of cytokines in elderly patients with major depressive disorder显示文摘 | Brambilla F Maggioni M | 1998 | Acta Psychiatr Scand1998，97，： | 1 |
| 6 | Cesium-134 and strontium-85 in strawberry plants following wet aerial deposition显示文摘 | Carini F Brambilla M Mitchell N | 2003 | Journal of Environmental Quality2003，32，6： | 1 |
| 7 | GABAergic dysfunction in mood disorders显示文摘 | Brambilla P Perez J Barale F | 2003 | Mol Psychiatry2003，8，8： | 1 |
| 8 | Gabaergicdysfunction in mood disorders显示文摘 | BRAMBILLA P PEREZ J BARALE F | 2003 | Mol Psychiatry2003，8，8： | 1 |
| 9 | GABAergic dysfunction in mood disorders显示文摘 | Brambilla P Perez J Barale F | 2003 | Mol Psychiatry2003，8，8： | 1 |
| 10 | Clinical and pharma- cological profile in a clenbuterol epidemic poisoning of contaminated beefmeat in Italy显示文摘 | BRAMBILLA G CENCI T FRANCONI F | 2000 | Toxicol Lett2000，114，13： | 1 |
| 11 | Efficiency of equilibrium cooling and vitrification procedures for the cryopreservation of ovarian tissue:comparative analysis between human and animal models显示文摘 | GANDOLFI F PAFFONI A PAPASSO BRAMBILLA E | 2006 | Fertil Steril2006，，： | 1 |
| 12 | Effects of phosphatidylserine therapy in geriatric patients with depressive disorders 显示文摘 | Maggioni M Piccotti GB Bondiolotti GP Panerai A Cenaeehi T Nobile P Brambilla F | 1990 | Acta Psychiatr1990，81，3： | 1 |
| 13 | Persistent organochlorinated pesticides and mechanisms of their toxicity显示文摘 | Mrema E J Rubino F M Brambilla G | 2013 | Toxicology2013，307，： | 1 |
| 14 | Blood levels of cytokines in elderly patients with major depressive disorders 显示文摘 | Brambilla F Maggioni M | 1998 | Acta Psychiatr Scand1998，97，： | 1 |
| 15 | Early detection of lung cancer:role of biomarkers显示文摘 | Brambilla C Fievet F Jeanmart M | 2003 | Eur Respir J Suppl2003，39，： | 1 |
| 16 | Structure of Do- nor Molecule 9, 9-Bis(Methoxymethyl)-Fluorene in Ziegler- Natta Catalyst by Infrared Spectroscopy and Quantum Chemical Calculation显示文摘 | Brambilla L Zerbi G Piemontesi F | 2010 | JPhys Chem C2010，114，11： | 1 |
| 17 | Early onset ofpuberty in young girls:An Italian cross-sectional study显示文摘 | RUSSO G BRAMBILLA P DELLA BEFFA F | 2012 | J Endocri-nolog Invest2012，35，9： | 1 |
| 18 | Pulmonary atypical carcinoid: predictors of survival in 106 cases 显示文摘 | Beasley M B Thunissen F B Brambilla E | 2000 | Hum Pathol2000，31，： | 1 |
| 19 | Blood levels of cytokines in elderly patients with major depressive disorder显示文摘 | Brambilla F Maggioni M | | 0，，： | 1 |
| 20 | Supercontinuumg-eneration in tapered bismuth silicate fibres 显示文摘 | Brambilla G Koizumi F Finazzi V | 2005 | ElectroLett2005，41，： | 1 |
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