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	题名	作者	年代	出处	被引量
1	Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man显示文摘	BOSMA PJ SEPPEN J GOLDHOORN B	1994	J Biol Chem1994，269，17：	1
2	UGT1A1 * 28 allele and coronary heart disease, the Rotterdam Study显示文摘	Bosma PJ van der Meer IM Bakker CT	2003	Clin Chem2003，49，7：	1
3	Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors 显示文摘	Wesseling JG Bosma PJ Krasnykh V	2001	Gene Ther2001，8，13：	1
4	The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome显示文摘	Bosma PJ Chowdhury JR Bakker C	1995	N Engl J Med1995，333，18：	1
5	Human plasminogen actvator inhibitor gene显示文摘	Bosma PJ Eva A Van den Berg	1998	J Biol Chom1998，263，9：	1
6	A mutation in the human canalicular muhispecific organic anion transporter gene causes the Dubin-Johnsan syndrome 显示文摘	Paulusma CC Kool M Bosma PJ	1997	Hepatology1997，25，6：	1
7	Persistent uncon- jugated hyperbilirubinemia after liver transplantation due to an abnormal bilirubin UDP-glucuronosyltransfe-rase gene promoter sequence in the donor显示文摘	JANSEN PL BOSMA PJ BAKKERC etal	1997	J Hepatol1997，，27：	1
8	The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome显示文摘	BOSMA PJ ROY CHOWDHURY J BAKKER C		0，，：	1
9	UGT- 1A1*28 allele and coronary heart disease: the Rotterdam Study显示文摘	BOSMA PJ VANDER MEER IM BAKKER CT	2003	Clin Chem2003，49，7：	1
10	The genetic basis of the reducedexpression of bilimbin UDP-glucuronyhranseferase I in Gillert's syndrome显示文摘	Bosma PJ Chowdhury JR Bakker C el al	1995	N Engl JMed1995，333，18：	1
11	Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo显示文摘AIM:To generate an adenoviral vector specifically targeting the EphA2 receptor(EphA2R) highly expressed on pancreatic cancer cells in vivo.METHODS:YSA,a small peptide ligand that binds the EphA2R with high affinity,was inserted into the HI loop of the adenovirus serotype 5 fiber knob.To further increase the specificity of this vector,binding sites for native adenoviral receptors,the coxsackie and adenovirus receptor(CAR) and integrin,were ablated from the viral capsid.The ablated retargeted adenoviral vector was produced on 293T cells.Specifi c targeting of this novel adenoviral vector to pancreatic cancer was investigated on established human pancreatic cancer cell lines.Upon demonstrating specifi c in vitro targeting,in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.RESULTS:Ablation of native cellular binding sites reduced adenoviral transduction at least 100-fold.Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor.YSA-mediated transduction was inhibited by addition of synthetic YSA peptide.The transduction specificity of the ablated retargeted vector towards human pancreatic cancer cells was enhanced almost 10-fold in vitro.In a subsequent in vivo study in a nude(nu/nu) mouse model however,no increased adenoviral targeting to subcutaneously growing human pancreas cancer nodules was seen upon injection into the tail vein,nor upon injection into the peritoneum.CONCLUSION:Targeting the EphA2 receptor increases specificity of adenoviral transduction of human pancreatic cancer cells in vitro but fails to enhance pancreatic cancer transduction in vivo.	Michael A van Geer Conny T Bakker Naoya Koizumi Hiroyuki Mizuguchi John G Wesseling Ronald PJ Oude Elferink Piter J Bosma	2009	World Journal of Gastroenterology2009，15，22：	1
12	The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase I in Gilbert's syndrome 显示文摘	Bosma PJ Chowdhury JR Bakker C	1995	N Engl J Med1995，333，18：	1
13	Inherited disorders of bilirubin metabolism显示文摘	Bosma PJ	2003	J Hepatol2003，38，1：	1
14	The genetic basis of the reduced expression of bilirubin UDPglucuronosyltransferase 1 in Gilbert's syndrome显示文摘	Bosma PJ Chowdhury JR Bakker C	1995	N Engl J Med1995，333，18：	1
15	Congenital jaun- dice in rats with a mutation in a multidrug resistance-associated proteingene 显示文摘	Paulusma CC Bosma PJ Oude Elferink RP	1996	Science1996，271，5252：	1
16	Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrintargeted adenoviral vectors显示文摘	Wesseling JG Bosma PJ Krasnykh V	2001	Gene Ther2001，8，13：	1
17	Congenital jaundice in rats with a mutation in a multidrug resistance ssociated protein gene显示文摘	Paulusma CC Bosma PJ Zaman GJ	1996	Science1996，271，5252：	1
18	Intra-operative arteriography in 'arterialembolectomy显示文摘	Bosma HW J6rning PJ	1990	Eur J Vasc Surg1990，4，5：	1
19	Perirectal lymph nodes in rectal cancer:in vitro correlation of sonographic parameters and histopathologic findings显示文摘	Hulsmans FH Bosma A Mulder PJ	1992	Radiology1992，184，2：	1
20	Inherited disorders of bilirubin metabolism显示文摘	Bosma PJ	2003	J Hepatol2003，38，：	1

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