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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Differential expression and regulation of toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 3 | Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells 显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | The Journal of Immunology2000，164，11： | 1 |
| 4 | Differential expres- sion and regulation of toll-like receptors (TLR) in human leukoeytes: selective expression of TIAL3 indendritic ceils 显示文摘 | MUZIO M BOSISIO D POLENTARUTYI N | 2000 | J Immunol2000，164，： | 1 |
| 5 | Toll-like receptor family and signalling pathway 显示文摘 | Muzio M Polentarutti N Bosisio D | 2000 | Biochem Soc Trans2000，28，5： | 1 |
| 6 | Differential expression and regulation of toil-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 7 | Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 8 | Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes:Selective Expression of TLR3 in Dendritic Cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | The Journal of Immunology2000，164，： | 1 |
| 9 | Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells显示文摘 | MUZIO M BOSISIO D POLENTARUTTI N | 2000 | J Immunol2000，164，： | 1 |
| 10 | Differential expression and regulation of toll-like receptors (TLR)in human leukocytes: selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 11 | Differential expression and regulation of Toll-like receptors ( TLR ) in human leukocytes: selective expression of TLR3 in dendritic cells 显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，： | 1 |
| 12 | Stimulation of toll- like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide 显示文摘 | Bosisio D Polentarutti P Sironi M | 2002 | Blood2002，99，9： | 1 |
| 13 | Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma 显示文摘 | VERMI W LONARDI S BOSISIO D | 2008 | J Pathol2008，216，3： | 1 |
| 14 | Identification of CXCL1 3 as a new marker for follicular dendritic cell sarcoma显示文摘 | Vermi W Lonardi S Bosisio D | 2008 | J Pathol2008，216，3： | 1 |
| 15 | Differential expression and regulation of toll-like receptors(TLR)in human leukocytes:selective expression of TLR3in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | Immunol2000，164，11： | 1 |
| 16 | Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma显示文摘 | Vermi W Lonardi S Bosisio D | 2008 | J Pathol2008，216，3： | 1 |
| 17 | Differential expression and regulation of Toll-like receptors(TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells显示文摘 | Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
| 18 | Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells 显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J hmnunol2000，164，11： | 1 |
| 19 | Diferential expression and regulation of toll- like receptors (TLR) in human leukoeytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | Immunol2000，164，11： | 1 |
| 20 | Differential expression and regulation of Toll-like receptors (TLR) in human leukocytes:selective expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N | 2000 | J Immunol2000，164，11： | 1 |
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