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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis显示文摘 | Juan G. Abraldes Ilaria Tarantino Juan Turnes Juan Carlos Garcia-Pagan Juan Rodés Jaime Bosch | 2003 | Hepatology2003，，4： | 3 |
| 3 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 4 | Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis显示文摘 | Pere Ginès Juan Uriz Blas Calahorra Guadalupe Garcia–Tsao Patrick S. Kamath Luis Ruiz Del Arbol Ramón Planas Jaime Bosch Vicente Arroyo Juan Rodés | 2002 | Gastroenterology2002，，6： | 2 |
| 5 | Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes显示文摘 | Li GR Yang B Feng J Bosch RF Carrier M Nattel S | 1999 | Am J Physiol1999，276，12： | 2 |
| 6 | Epidemiologic classification of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch F X de Sanjosé S | 2003 | New Engl J Med2003，348，6： | 1 |
| 7 | Epidemio-logic classificationof human papillomavirus types associ- ated withcervical cancer显示文摘 | Munoz N Bosch FX De- Sanjose S | 2003 | N Engl J Med2003，348，6： | 1 |
| 8 | Epidemiologic classification of human papillomavlrus types associated with cervical cancer 显示文摘 | Munoz N Bosch F X de Sanjose S | 2003 | N Engl J Med2003，348，： | 1 |
| 9 | The prospects of HPV vaccination in cervical cancer prevention: results of a new inde- pendent trial显示文摘 | Bosch F X de Sanjose S Castellsague X | 2011 | Cancer Discov2011，1，5： | 1 |
| 10 | Epidemiologic classify-cation of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch FX de-Sanjose S | | 0，，06： | 1 |
| 11 | Enhanced oxidation of flava- neols and proanthocyanidin accumulation in water - stressed tea Plants 显示文摘 | Hemandez I Alegre L Munne - Bosch S | 2006 | Phytochemistry2006，67，： | 1 |
| 12 | Epidemiologic classification of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch FX de Sanjos6 S | 2003 | N Engl J Med2003，348，6： | 1 |
| 13 | Human papillomavirus in cervical cancer显示文摘 | Bosch Fx de sanjose S | 2002 | curr Oncol Rep2002，4，2： | 1 |
| 14 | Epidemiologic classification of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch FX de Sanjose S Herrero R | 2003 | N Engl J Med2003，348，： | 1 |
| 15 | Diurnal of variations of photosynthesis and dew absorption by leaves in two evergreen shrubs growing in Mediterranean field conditions显示文摘 | Munn~-Bosch S Nogu6s S Alegre L | 1999 | New Phy- tologist1999，144，： | 1 |
| 16 | Renal insuf- ficiency as a preditor of cardiovascular outcomes and the impact of ramipril~ the HOPE radomized trial显示文摘 | Mann J F Gerstein H C Pogue J Bosch J Yusuf S | 2001 | Ann Intern Med2001，134，： | 1 |
| 17 | Epidemiologic classificationof human papillomavirus types associated with cervical cancer 显示文摘 | Munoz N Bosch FX Sanjose S | 2003 | N Engl J Med2003，348，： | 1 |
| 18 | Nutrient manage- ment planning on four Virginia livestock farms:impacts on net in- come and nutrient losses 显示文摘 | VanDyke L S Pease J W Bosch D J | 1999 | Journal of Soil and Water Conserva- tion1999，54，2： | 1 |
| 19 | Epidemiologic classification of human papillomavirus types associated with cervical cancer显示文摘 | Munoz N Bosch FX de Sanjose S | 2003 | New Engl J Med2003，348，51： | 1 |
| 20 | Predicting lymph nodemetastasis in pTl colorectal cancer : a systematic review of risk fac-tors providing rationale for therapy decisions 显示文摘 | Bosch SL Teerenstra S de Wilt JH | 2013 | Endoscopy2013，45，10： | 1 |
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