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| 1 | Magnetic resonance imaging in breast cancer:A literature review and future perspectives显示文摘Early detection and diagnosis of breast cancer are essential for successful treatment. Currently mammography and ultrasound are the basic imaging techniques for the detection and localization of breast tumors. The low sensitivity and specificity of these imaging tools resulted in a demand for new imaging modalities and breast magnetic resonance imaging(MRI) has become increasingly important in the detection and delineation of breast cancer in daily practice. However, the clinical benefits of the use of pre-operative MRI in women with newly diagnosed breast cancer is still a matter of debate. The main additional diagnostic value of MRI relies on specific situations such as detecting multifocal, multicentric or contralateral disease unrecognized on conventional assessment(particularly in patients diagnosed with invasive lobular carcinoma), assessing the response to neoadjuvant chemotherapy, detection of cancer in dense breast tissue, recognition of an occult primary breast cancer in patients presenting with cancer metastasis in axillary lymph nodes, among others. Nevertheless, the development of new MRI technolo-gies such as diffusion-weighted imaging, proton spectroscopy and higher field strength 7.0 T imaging offer a new perspective in providing additional information in breast abnormalities. We conducted an expert literature review on the value of breast MRI in diagnosing and staging breast cancer, as well as the future potentials of new MRI technologies. | Gisela LG Menezes Floor M Knuttel Bertine L Stehouwer Ruud M Pijnappel Maurice AAJ van den Bosch | 2014 | World Journal of Clinical Oncology2014，5，2： | 25 |
| 2 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 3 | CXCR4表达可增强弥漫大B细胞淋巴瘤的播散能力并降低患者生存期显示文摘在一些血液系统恶性肿瘤中,趋化因子受体CXCR4与恶性B细胞的迁徙和转移有关。 CXCR4在血液系统肿瘤中过表达已经得到证实,但对弥漫大B细胞淋巴瘤( DLBCL)的作用尚不清楚。为此,作者采用DLBCL细胞系着重对体外细胞迁移和体内播散过程中CXCR4的作用进行研究,并评估94例DLBCL患者活检标本CXCR4表达的预后意义。 | Moreno M J Bosch R Dieguez-Gonzalez R 胡舜 余英豪 | 2015 | 临床与实验病理学杂志2015，31，10： | 3 |
| 4 | CXCR4表达促进弥漫大B细胞淋巴瘤播散并降低患者生存显示文摘Moreno M J, Bosch R, Dieguez-Gonzalez R, et al. CXCRg ex- pression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. J Pathol, 2015,235 (3) :445 - 55.在一些血液系统恶性肿瘤中,趋化因子受体CXCR4涉及恶性B细胞的迁移和播散。尽管研究发现CXCR4在血液系统肿瘤过表达,但该受体在弥漫大B细胞淋巴瘤(DL—BCL)中的作用仍未可知。CXCR4在多种肿瘤中是预后不良的标记,与肿瘤转移及患者生存降低相关。 | Moreno M J Bosch R Dieguez-Gonzalez R 魏建国 许春伟 邰艳红 | 2015 | 临床与实验病理学杂志2015，31，8： | 3 |
| 5 | Effects of dietary oligosaccharides on the growth performance feacal characteristics of young growing pigs 显示文摘 | Houdijk J G M: Bosch M W Verstegen H J | 1998 | Animal Feed Science Technology1998，71，： | 2 |
| 6 | Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes显示文摘 | Li GR Yang B Feng J Bosch RF Carrier M Nattel S | 1999 | Am J Physiol1999，276，12： | 2 |
| 7 | Leaves of Field-Grown Mastic Trees Suffer Oxidative Stress at the Two Extremes of their Lifespan显示文摘Leaf senescence is a complex phenomenon occurring in all plant species, but it is still poorly understood in plants grown in Mediterranean field conditions and well-adapted to harsh climatic conditions. To better understand the physiological processes underlying leaf senescence in mastic trees (Pistacia lentiscus L.), we evaluated leaf growth, water and N content, photosystem II (PSII) photochemistry, lipid peroxidation and levels of photosynthetic pigments, antioxidants, abscisic acid, and salicylic acid and jasmonic acid during the complete leaf lifespan, from early expansion to late senescence in relation to natural climatic conditions in the field. While mature leaves suffered from water and N deficit during late spring and summer, both young (emerging) and old (senescing) leaves were most sensitive to photo-oxidative stress, as indicated by reductions in the F v/F m ratio and enhanced lipid peroxidation during late autumn and winter. Reductions in the F v/F m ratio were associated with low α-tocopherol (vitamin E) levels, while very old, senescing leaves additionally showed severe anthocyanin losses. We have concluded that both young (emerging) and old (senescing) leaves suffer oxidative stress in mastic trees, which may be linked in part to suboptimal temperatures during late autumn and winter as well as to low vitamin E levels. | Marta Juvany Maren Müller Sergi Munn-Bosch | 2012 | Journal of Integrative Plant Biology2012，54，8： | 2 |
| 8 | ZAP-70 expression as a sunogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia显示文摘 | Crespo M Bosch F Villamor N | 2003 | N Engl J Med2003，348，18： | 1 |
| 9 | The effects of 5-aza- 20-deoxyeytidine(decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes 显示文摘 | van den Bosch J Lubbert M Verhoef G | 2004 | Leuk Res2004，28，8： | 1 |
| 10 | Primary liver cancer:worldwide incidence and trends显示文摘 | Bosch F X Ribes J Diaz M Cleries R | 2004 | Gastroenterology2004，127，51： | 1 |
| 11 | The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments 显示文摘 | BOSCH G DE MOS M VAN BINSBERGEN R | 2009 | Equine Vet J2009，41，4： | 1 |
| 12 | Primary liver cancer:worldwide incidence and trends显示文摘 | Bosch FX Ribes J Diaz M | | 0，，： | 1 |
| 13 | Overexpression of FABP 7 in Down Syndrome Fetal Brain Is Associated with PKNOX1 Gene-dosage Imbalance 显示文摘 | Sanchez Font M F Bosch Comas A Marfany G | 2003 | Nuclei Acids Res2003，31，11： | 1 |
| 14 | Effects of dietary oligosaccharides on the growth performance and faecal characteristics of young growing pigs 显示文摘 | Houdijk J G M Bosch M W Verstegen M W A | 1998 | Animal Feed Science and Technology1998，71，： | 1 |
| 15 | Fluoro scopic positioning of sacroiliac serews in 88 patients显示文摘 | Van den Bosch E W Van Zwienen C M Van Vugt A B | 2002 | JTrauma2002，53，1： | 1 |
| 16 | Rupture of intracranial aneurysms during treatment with Guglielmi detachable coils: inci dence, outcome and risk factors显示文摘 | Sluzewski M Bosch JA van Rooij W J | 2001 | J Neurosurg2001，94，2： | 1 |
| 17 | Primary liver canc-er:w orldw ide incidence and trends显示文摘 | Bosch F X Ribes J Díaz M | 2004 | Gastroenterolo-gy2004，127，51： | 1 |
| 18 | Growth hormone treatment promotes guided bone regeneration in rat calvarial defects显示文摘 | Cacciafesta V Dalstra M Bosch C | 2001 | Eur J Orthod2001，23，6： | 1 |
| 19 | Inhibition of microbiological sulfide oxidation by methanethiol and dimethyl polysulfides at natron-alkaline conditions 显示文摘 | van den Bosch P L F de Graaff M Fortuny-Picornell M | 2009 | Appl Microbiol Biotechnol2009，83，3： | 1 |
| 20 | Pectin methylesterase,a regulator of pollen tube growth显示文摘 | Bosch M Cheung A Y Hepler P K | 2005 | Plant Physiology2005，138，3： | 1 |
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