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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Effect of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study显示文摘 | van den Bosch F Kruithof E Baeten D | 2000 | Annals of the Rheumatic Disease2000，，： | 2 |
| 3 | Obesity and the risk of spontaneous abortion after oocyte donation显示文摘 | Bellver J Rossal LP Bosch E | 2003 | Fertil Steril2003，79，5： | 1 |
| 4 | Regulation production of mature insulin by non-β-cells显示文摘 | Gros L Montoliu L Riu E Lebrigand L Bosch F | | 0，，： | 1 |
| 5 | Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its rela tionship with in vitro fertilization outcome显示文摘 | Bosch E Valencia I Escudero E | 2003 | Fertil Steril2003，80，6： | 1 |
| 6 | Fluoro scopic positioning of sacroiliac serews in 88 patients显示文摘 | Van den Bosch E W Van Zwienen C M Van Vugt A B | 2002 | JTrauma2002，53，1： | 1 |
| 7 | Evidenced-based investigations and treatments of recurrent pregnancy loss显示文摘 | Christiansen OB Nybo AAM Bosch E | 2005 | Fertil Steril2005，83，4： | 1 |
| 8 | Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cy- cles for in vitro fertilization : analysis of over 4000 cycles 显示文摘 | Bosch E Labarta E Crespo G | 2010 | Hum Reprod2010，25，8： | 1 |
| 9 | The unfolding clinical spectrum of POLG mutations显示文摘 | Blok MJ Van Den Bosch BJ Jongen E | 2009 | J Med Genet2009，46，11： | 1 |
| 10 | Beneficial effects of amantadine on L-dopa-induced dyskinesias in Parkinson' s disease 显示文摘 | Luginger E Wenning GK Bosch S | 2000 | Mov Disord2000，15，5： | 1 |
| 11 | Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors 显示文摘 | Bosch F Lopez-Guillermo A Campo E | 1998 | Cancer1998，82，： | 1 |
| 12 | Tachycardia-induced changes in Na' current in a chronic dog model of alrial fibrillation 显示文摘 | Rania Gaspo R Bosch RF Bou-Abbound E | 1997 | Circ Res1997，81，6： | 1 |
| 13 | Y chromosome STR haplotypes in four populations from northwest Africa 显示文摘 | BOSCH E CALAFELL F PEREZ-LEZAUN A | 2000 | Int J Legal Med2000，114，12： | 1 |
| 14 | Thermal processing of whole soya beans: Studies on the inactivation of antinutritional factors and effects on ileal digestibility in piglets显示文摘 | Qin G Ter Elst E R Bosch M W | 1996 | Anita Feed Sci Tech1996，57，： | 1 |
| 15 | A rapid solidphase fluorimetric may for measuring bacterial adherence, using DNA- binding stains 显示文摘 | BOSCH J A VEERMAN E C TURKENBURG M | 2003 | Microbiol Methods2003，53，1： | 1 |
| 16 | Optic nerve sheath meningiomas in patients in patients with neurofibromatosis type 2显示文摘 | Bosch MM Wichmann WW Boltshauser E | 2006 | Arch ophthalmol2006，124，3： | 1 |
| 17 | Epidemiology and significance of chicken infectious anemia virus infections in broilers and broiler parents under nonvaccinated European circumstances 显示文摘 | Dehead T P Van Den Bosch G Ducatell E R | 2001 | Avian Dis2001，45，： | 1 |
| 18 | Pasteurella mul- tocida exbB, exbD and tonB genes are physically linked but independently transcribed显示文摘 | Bosch M Garrido E Llagostera M | 2002 | FEMS Microbiol Lett2002，210，： | 1 |
| 19 | Individualised controlled ovarian stimulation(iCOS):maximising success rates for assisted reproductive technology patients显示文摘 | Bosch E Ezcurra D | 2011 | Reprod Biol Endocrinol2011，9，： | 1 |
| 20 | Obesity and the risk tff spontaneous abortion after oocyte donation显示文摘 | Bellver J Russal L Bosch E | 2012 | Fertil Steril2012，79，5： | 1 |
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