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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | An integrated multiscale approach for characterization of rock masses subjected to tunnel excavation显示文摘The design of tunnels must be conducted based on the knowledge of the territory. The longer the structure, the larger the area to be investigated, and the greater the number of surveys and tests to be performed in order to thoroughly examine all the relevant features. Therefore, optimization of the investigation process is strongly required to obtain complete and reliable data for the design of the infrastructure. The fast development of remote sensing technologies and the affordability of their products have contributed to proving their benefits as supports for investigation, encouraging the spreading of automatic or semi-automatic methods for regional scale surveys. Similarly, considering the scale of the rock outcrop, photogrammetric and laser scanner techniques are well-established techniques for representing geometrical features of rock masses, and the benefits of non-contact surveys in terms of safety and time consumption are acknowledged. Unfortunately, in most cases, data obtained at different scales of investigations are only partially integrated or compared, probably due to the missing exchange of knowledge among experts of different fields(e.g. geologists and geotechnical engineers). The authors,after experiencing such a lack of connection among the results of different surveys concerning tunnels,propose a multiscale approach for the optimization of the investigation process, starting from the regional scale, to obtain the data that can be useful not only for planning more detailed surveys in a preliminary phase, but also for making previsions on the discontinuity sets that are present in the rock masses subjected to excavations. A methodological process is proposed and illustrated by means of a case study. Preliminary results are discussed to highlight the potentiality of this method and its limitations. | Gessica Umili Sabrina Bonetto Anna Maria Ferrero | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 2 |
| 3 | FA polydisperse model for bubbly two-phase flow around a surface ship显示文摘 | Carrica P M Drew D Bonetto F | 1999 | International Journal of Multiphase Flow1999，25，： | 1 |
| 4 | An experimental study on air carry-un- der due to a plunging liquid jet 显示文摘 | Bonetto F Lahcy Jr R T | 1993 | International Journal of Mul- tiphase Flow1993，19，： | 1 |
| 5 | A new microbial biosensor for organic water pollution based on measurement of carbon dioxide production显示文摘 | Chiappini S A Kormes D J Bonetto M C | 2010 | Sensor Actuat B-Chem2010，148，1： | 1 |
| 6 | Spleen antibacterial peptides: high levels of PR-39 and presence of two forms of NK-lysin 显示文摘 | Bonetto V Andersson M Bergman T | 1999 | Cellular and Molecular Life Sciences1999，56，12： | 1 |
| 7 | Thiol-disulfide balance: from the concept of oxidative stress to that of redox regulation显示文摘 | Ghezzi P Bonetto V Fratelli M | 2005 | Antioid Redox Signal2005，7，78： | 1 |
| 8 | Macrophyte growth in a pilot-scale constructed wetland for industrial wastewater treatment 显示文摘 | Hadada H R Mainea M A Bonetto C A | 2006 | Chemosphere2006，63，10： | 1 |
| 9 | The in- teraction of background ocean air bubbles with a sur- face ship显示文摘 | Carrica P M Bonetto F J Drew D A etal | 1998 | Int J Numer Methods Fluids1998，28，： | 1 |
| 10 | A polydis- perse model for bubbly two phase flow around a sur- face ship显示文摘 | Carrica P M Drew D Bonetto F | 1999 | Int J Multiphase Flow1999，25，2： | 1 |
| 11 | High-frequency digital lock-in amplifier using random sampling 显示文摘 | SONNAILLON Maximiliano O URTEAGA Raul BONETTO Fabian J | 2008 | IEEE Transactions on Instrumentation and Measurement2008，57，3： | 1 |
| 12 | Caveolinopathies:translational implications of caveolin-3 in skeletal and cardiac muscle disorders显示文摘 | Gazzerro E Bonetto A Minetti C | 2011 | Handb Clin Neurol2011，101，： | 1 |
| 13 | Heat conduction and entropy production in anharmonic crystals with self-consistent stochastic reservoirs显示文摘 | BONETTO F LEBOWITZ J L LUKKARINEN J | 2009 | Journal og Statistical Phys2009，134，： | 1 |
| 14 | Multimodal Imaging of Nanovaccine Carriers Targeted to Human Dendritic Cells显示文摘 | Cruz LJ Tacken PJ Bonetto F | 2011 | Mol Pharm2011，8，2： | 1 |
| 15 | High-Frequency Digital Lock-In Amplifier Using Random Sampling显示文摘 | Sonnaillon M O Urteaga R Bonetto F J | 2008 | IEEE Transactionson Instrumentation and Measurement2008，57，3： | 1 |
| 16 | Thiol-disulfide bal- ance:from the concept of oxidative stress to that of redox regulation显示文摘 | Ghezzi P Bonetto V Fratelli M | 2005 | Antioxid Redox Signal2005，7，78： | 1 |
| 17 | Chaotic Hypothesis, Fluctuation Theorem and Singularities显示文摘 | F. Bonetto G. Gallavotti A. Giuliani F. Zamponi | 2006 | Journal of Statistical Physics2006，，1： | 1 |
| 18 | A low-cost, high-performance, digital signal processor-based lock-in amplifier capa- ble of measuring multiple frequency sweeps simultaneously 显示文摘 | Sonnaillon M O Bonetto F J | 2005 | Review of Scientific Instruments2005，76，2： | 1 |
| 19 | A polydisperse model for bubbly two-phrase flow around a surface ship 显示文摘 | CARRICA P M DREW D A BONETTO F J | 1999 | Int J Multiphase Flow1999，25，： | 1 |
| 20 | Macrophyte growth in a pilot-scale constructed wetland for industrial wastewater treatment显示文摘 | HADAD H R MAINE M A BONETTO C A | 2006 | Chemosphere2006，63，10： | 1 |
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