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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | The dimen-sionality of the Maslach Burnout Inventory across small business owners and educators 显示文摘 | BOLES J S DEAN D H XAVIER J M R | 2000 | Journal of Vocational Behavior2000，，： | 1 |
| 3 | A reverse outcome bias:The influence of multiple reference Points on the evaluation of outcomes and decisions显示文摘 | Boles T L Messick D M | 1995 | Organizational Behavior and Human Decision Processes1995，6，3： | 1 |
| 4 | Comparative response of two barrier soils to post compaction water content variations 显示文摘 | Phifer M Boles D Drumm E Wilson GV | 1995 | ASCE GSP1995，46，： | 1 |
| 5 | Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae显示文摘 | Brat D Boles E Wiedemann | 2009 | Appl Environ Microbial2009，75，： | 1 |
| 6 | Effect of dietary protein level on nitrogen metabolism in lambs: studies using is N-nitrogen显示文摘 | Bunting L D Boling J A MacKown C T Muntifering R B | 1987 | Journal of Animal Science1987，64，： | 1 |
| 7 | Excavation force in reduced gravity environment显示文摘 | BOLES W W SCOTT W D CONNOLLY J F | 1997 | Journal of Aerospace Engineering1997，10，2： | 1 |
| 8 | Hip adduction does not affect VMO EMG amplitude or VMO: VL ratios during a dynamic squat exercise 显示文摘 | Boling M Padua D Blackburn JT | 2006 | J Sport Reh2006，15，3： | 1 |
| 9 | The dimensionality of the Maslach Burnout Inventory across small business owners and educators显示文摘 | Boles J S Dean D H Xavier J M R Short J C Wang G P | 2000 | Journal of Vocational Behavior2000，56，： | 1 |
| 10 | Synovial plieae in the knee显示文摘 | Boles C A Martin D F | 2001 | AJR2001，177，1： | 1 |
| 11 | Computer Animated Digital Arc Diagnostic System 显示文摘 | SHEA J J BOLES D CHIEN Y K | 1994 | IEEE Trans on Comp Pack Manu Tech1994，17，1： | 1 |
| 12 | Omega automated laser control and data acquisition显示文摘 | Boles J Pessel D Forsley L | 1991 | IEEE Journal of Quantum Electronics1991，17，9： | 1 |
| 13 | The effects of citric acid on phytate-phosphorus utilization in young chicks and pig显示文摘 | Boling S D Webel D M Mavromichalis I | 2000 | J Anim Sci2000，78，： | 1 |
| 14 | Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae显示文摘 | BRAT D BOLES E WIEDEMANN B | 2009 | Applied and Environmental Microbiology2009，75，8： | 1 |
| 15 | Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein显示文摘 | Hendershot L Bole D K(o)hler G | | 0，，03： | 1 |
| 16 | In vitro selection of RNA lectins:using combinatorial chemistry to interpret ribozyme evolution显示文摘 | Lato S M Boles A R Ellington A D | | 0，，05： | 1 |
| 17 | Sex differences in spatial ability: a lateralization of function approach 显示文摘 | Rilea SL Roskos-Ewoldsen B Boles D | 2004 | Brain Cogn2004，56，3： | 1 |
| 18 | Rituximab in combination with high-dose methylprednisolone for the treatment of fludarabine refractory high-risk chronic lymphocytic leukemia显示文摘 | CASTRO J E SANDOVAL-SUS J D BOLE J | 2008 | Leukemia2008，22，： | 1 |
| 19 | In vitro selection of RNA lectins: using combinatorial chemistry to interpret ribozyme evolution显示文摘 | LATO S M BOLES A R ELLINGTON D A | 1995 | Chem Biol1995，2，5： | 1 |
| 20 | Effect of dietary protein level on nitrogen metabolism in the growing bovine: Nitrogen recycling and intestinal protein supply in calves 显示文摘 | Bunting L D Boling J A MacKown C T | 1989 | J Animal Science1989，67，： | 1 |
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