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		题名	作者	年代	出处	被引量
	1	Characterisationof T and B lymphocytes infiltrating abdominal aortic aneurysm显示文摘	Ocana E Bohórquez JC Pérez-Requena J	2003	Atherosclerosis2003，170，1：	1
	2	MON and MMH pressure surges for a simplified propellant feed system显示文摘	BOH P HALEWYN S	2000	ESA SP2000，465，：	1
	3	Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms显示文摘	Esther Ocana Juan - Carlos Bohórquez José Pérez- Requena	2003	Atherosclerosis2003，170，：	1
	4	Thermal stability of microhardness and internal stress of hard a-C films with predominantly sp bonds显示文摘	KULIKOVSKU V Vorlícek V Bohác P	2003	Diamond Relat Mater2003，12，：	1
	5	Mechanical properties of hydrogen-free a-C:Si films显示文摘	KULIKOVSKY V Vorlícek V Bohác P	2004	Diamond Relat Mater2004，13，：	1
	6	Assessment of the geometric profde of the Amplatzer and cardial septal occluder by three dimensional echocardiography 显示文摘	P Acar Z Saliba P Boh Hoeffer	2001	Heart2001，85，：	1
	7	Loss of efficacy and safety of the switch from infliximab original to infliximab biosimilar(CT-P13)in patients with inflammatory bowel disease显示文摘BACKGROUND Infliximab original has changed the natural history of inflammatory bowel diseases(IBD) over the past two decades. However, the recent expiration of its patent has allowed the entry of the first Infliximab biosimilar into the European and Spanish markets. Currently switching drugs data in IBD are limited. AIM To compare the efficacy of infliximab biosimilar, CT-P13, against infliximab original, analyzing the loss of response of both at the 12 mo follow-up in patients with IBD.METHODS An observational study of two cohorts has been conducted. One retrospective cohort that included patients with IBD treated with Infliximab original, and a prospective cohort of patients who were switching from infliximab original to infliximab biosimilar(CT-P13). We had analyzed the overall efficacy and loss of efficacy in patients in remission at the end of one year after treatment with the original drug compared to the results of the year of treatment with the biosimilar.RESULTS98 patients(CD 67, CU 31) were included in both cohorts. The overall efficacy for infliximab original per year of treatment was 71% vs 68.2% for infliximab biosimilar(P = 0.80). The loss of overall efficacy at 12 mo for infliximab original was 6.6% vs 14.5% for infliximab biosimilar(P = 0.806). The loss of efficacy in patients who were in basal remission was 16.3% for infliximab original vs 27.1% for infliximab biosimilar. Adverse events were 9.2% for infliximab original vs 11.2% for infliximab biosimilar. CONCLUSION The overall efficacy and loss of treatment response with infliximab biosimilar(CT-P13) is similar to that observed with infliximab original in patients who were switching at the 12 mo follow-up. There is no difference in the rate of adverse events.	María Fernanda Guerra Veloz Federico Argüelles-Arias Luisa Castro Laria Belén Maldonado Pérez Antonio Benítez Roldan Raúl Perea Amarillo Vicente Merino Bohórquez Miguel Angel Calleja Angel Caunedo Alvarez Angel Vilches Arenas	2018	World Journal of Gastroenterology2018，24，46：	0

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