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| 1 | Tick-borne encephalitis: A review of epidemiology, clinical characteristics, and management显示文摘Tick-borne encephalitis is an infection of central nervous system caused by tick-borne encephalitis virus transmitted to humans predominantly by tick bites. During the last few decades the incidence of the disease has been increasing and poses a growing health problem in almost all endemic European and Asian countries. Most cases occur during the highest period of tick activity, in Central Europe mainly from April to November. Tickborne encephalitis is more common in adults than in children. Clinical spectrum of the disease ranges from mild meningitis to severe meningoencephalitis with or without paralysis. Rare clinical manifestations are an abortive form of the disease and a chronic progressive form. A post-encephalitic syndrome, causing long-lasting morbidity that often affects the quality of life develops in up to 50% of patients after acute tick-borne encephalitis. Clinical course and outcome vary by subtype of tick-borne encephalitis virus(the disease caused by the European subtype has milder course and better outcome than the disease caused by Siberian and Far-Easter subtypes), age of patients(increasing age is associated with less favorable outcome), and host genetic factors. Since clinical features and laboratory results of blood and cerebrospinal fluid are nonspecific, the diagnosis must be confirmed by microbiologic findings. The routine laboratory confirmation of the tick-borne encephalitis virus infection is based mainly on the detection of specific Ig M and Ig G antibodies in serum(and cerebrospinal fluid), usually by enzyme-linked immunosorbent assay. There is no specific antiviral treatment for tick-borne encephalitis. Vaccination can effectively prevent the disease and is indicated for persons living in or visiting tick-borne encephalitis endemic areas. | Petra Bogovic Franc Strle | 2015 | World Journal of Clinical Cases2015，3，5： | 10 |
| 2 | Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury显示文摘The intrinsic ability of peripheral nerves to regenerate after injury is extremely limited,especially in case of severe injury.This often leads to poor motor function and permanent disability.Existing approaches for the treatment of injured nerves do not provide appropriate conditions to support survival and growth of nerve cells.This drawback can be compensated by the use of gene therapy and cell therapy-based drugs that locally provide an increase in the key regulators of nerve growth,including neurotrophic factors and extracellular matrix proteins.Each growth factor plays its own specific angiotrophic or neurotrophic role.Currently,growth factors are widely studied as accelerators of nerve regeneration.Particularly noteworthy is synergy between various growth factors,that is essential for both angiogenesis and neurogenesis.Fibroblast growth factor 2 and vascular endothelial growth factor are widely known for their proangiogenic effects.At the same time,fibroblast growth factor 2 and vascular endothelial growth factor stimulate neural cell growth and play an important role in neurodegenerative diseases of the peripheral nervous system.Taken together,their neurotrophic and angiogenic properties have positive effect on the regeneration process.In this review we provide an in-depth overview of the role of fibroblast growth factor 2 and vascular endothelial growth factor in the regeneration of peripheral nerves,thus demonstrating their neurotherapeutic efficacy in improving neuron survival in the peripheral nervous system. | Kamilla Faritovna Idrisova Alina Kazymovna Zeinalova Galina Andreevna Masgutova Alexey Andreevich Bogov Jr. Cinzia Allegrucci Valeriia Yurievna Syromiatnikova Ilnur Ildusovich Salafutdinov Ekaterna Evgenievna Garanina Dina Ivanovna Andreeva Adilet Abdullaatovich Kadyrov Albert Anatolevich Rizvanov Ruslan Faridovich Masgutov | 2022 | Neural Regeneration Research2022，17，6： | 6 |
| 3 | Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve显示文摘Vascular endothelial growth factor(VEGF) and fibroblast growth factor 2(FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including peripheral nerve system. In the present study, we elucidated the local and systemic effects of plasmid construct рBud-coVEGF165-coFGF2 injected into the epineurium of intact rat sciatic nerve. Results of histological examination of sciatic nerve and multiplex immunoassays of serum showed the absence of immunogenicity and biosafety of plasmid рBud-coVEGF165-coFGF2. Moreover, local administration of plasmid DNA construct resulted in significantly decreased levels of pro-inflammatory cytokines in the peripheral blood, including tumor necrosis factor α(TNFα) and interleukin-12, and significantly increased levels of cytokines and chemokines including Regulated upon Activation, Normal T Cell Expressed and Presumably Secrete(RANTES), epidermal growth factor, interleukin-2, and monocyte chemoattractant protein 1. These changes in the peripheral blood on day 7 after injection of plasmid construct рBud-coVEGF165-coFGF2 show that the plasmid construct has systemic effects and may modulate immune response. At the same time, reverse transcriptionpolymerase chain reaction revealed transient expression of coFGF2, coVEGF165, ratFGF2 and ratVEGFA with direct transport of transcripts from distal part to proximal part of the sciatic nerve. Immunohistochemical staining revealed prolonged presence of VEGFA in sciatic nerve till 14 days post-injection. These findings suggest that local administration of plasmid construct рBud-coVEGF165-coFGF2 at a concentration of 30 ng/μL results in the formation of pro-angiogenic stimuli and, and the plasmid construct, used as a drug for gene therapy, might potentially facilitate regeneration of the sciatic nerve. The study was approved by the Animal Ethics Committee of Kazan Federal University, procedures were approved by the Local Ethics Committee(approval No. 5) on May 27, 2014. | Ruslan Masgutov Alina Zeinalova Alexey Bogov Galina Masgutova Ilnur Salafutdinov Ekaterina Garanina Valeriia Syromiatnikova Kamilla Idrisova Adelya Mullakhmetova Dina Andreeva Liliya Mukhametova Adilet Kadyrov Igor Pankov Albert Rizvanov | 2021 | Neural Regeneration Research2021，16，9： | 3 |
| 4 | Resolution of crossing fibers with constrained compressed sensing using diffusion tensor MRI显示文摘 | Landman BA Bogovic JA Wan H | 2012 | NeuroImage2012，59，3： | 1 |
| 5 | Physiological role of IL-15 and IL-18 at the maternal-fetal interface 显示文摘 | Laskarin G Strbo N Bogovic Crncic T er al | 2005 | Chem Immunol Allergy2005，89，： | 1 |
| 6 | Influence of intraoperative cerebral oximetry monitoring on neurocognitive function after coronary artery bypass surgery: a randomized, prospective studydaggerdouble dagger 显示文摘 | Colak Z Borojevic M Bogovic A | 2015 | Eur J Cardiothorac Surg2015，47，3： | 1 |
| 7 | Fate of Listeria monocytogenes on fully ripened Greek Graviera cheese stored at 4,12 or 25 degrees C in air or vacuum packages:in situ PCR detection of a cocktail of bacteri- ocins potentially contributing to pathogen inhibition显示文摘 | Giannou E Kakouri A Bogovic Matijasic B | 2009 | Journal Food Protection2009，72，3： | 1 |
| 8 | IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decid- ual lymphocytes 显示文摘 | Tokmadzic VS Tsuji Y Bogovic T | 2002 | Am J Reprod Immunol2002，48，4： | 1 |
| 9 | Ability of Lactobacillus gasseri K7 to inhibit Escherichia coli adhesion in vitro on CaCo-2 cells and ex vivo on pigs'jejunal tissue显示文摘 | Bogovic B Narat M M Peternel M Z | 2006 | International Journal of Food Microbiology2006，107，： | 1 |
| 10 | Effects of two probiotic additives containing Bacillus spores on carcass characteristics, blood lipids and cecal volatile fatty acids in meat type chickens 显示文摘 | Novak R Bogovic Matijagic B Terfcic D | 2011 | J Anim Physiol Anim Nutr (Berl)2011，95，4： | 1 |
| 11 | The double flap partial recon- struction technique for the avulsion-type finger injuries: a case report显示文摘 | Bogov A Mullin R Kubitskiy A | | J Hand Surg Eur Vol0，36，5： | 1 |
| 12 | Ability of Lactobacillus gasseri K7 to inhibit Escherichia coli adhesion in vitro on Caco- 2 cells and ex vivo on pigs'jejunal tissue 显示文摘 | Bogovic B M Narat M Zoric M P | 2006 | Int J Food Microbiol2006，107，1： | 1 |
| 13 | Physiological role of IL - 15 and IL - 18 at the maternal - fetal interface 显示文摘 | Laskarin G Strbo N Bogovic Cmeie T | 2005 | Chem Immmunol Allergy2005，89，： | 1 |
| 14 | Physio- logical role of IL-15 and IL-18 at the maternal-fetal interface 显示文摘 | LASKARIN G STRBO N Bogovic Crncic T | 2005 | Chem Immunol Allergy2005，89，： | 1 |
| 15 | Resolution of crossing fibers with constrained compressed sensing using diffusion tensor MRI 显示文摘 | Landman BA Bogovic JA Wan H | 2012 | Neuroimage2012，59，： | 1 |
| 16 | Whole-body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer显示文摘 | Douwes F BogoviC J Douwes O | 2004 | Int J Clin Oncol2004，9，2： | 1 |
| 17 | Whole-body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer 显示文摘 | Douwes F Bogovic J Douwes O | 2004 | Int J Clin Oncol2004，9，1： | 1 |
| 18 | Physiological role of IL-15 and IL-18 at the maternal-fetal interface显示文摘 | LASKARIN G STRBO N BOGOVIC CRNCIC T | | 0，，： | 1 |
| 19 | Ability of Lactubacillus gasser K7 to inhibit Esckerichia coli adhesion in vitro on Caco 2 cells and exvi vo on pigs' jejunal tissue显示文摘 | Bojana Bogovic Matijasi Mojca Narat Metoda Zoric Peter nel | 2006 | Int J Food Microbiol2006，107，： | 1 |
| 20 | The double flap partial re- construction technique for the avulsion-type finger injuries:a case report显示文摘 | Bogov A Mullin R Kubitskiy A | 2011 | J Hand Surg Eur2011，36，5： | 1 |
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