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| 1 | Production of latent transforming growth factor-beta and other inhibitory factors by cultured murine iris and ciliary body cells显示文摘 | Bleicher P A Vibbaral C A | 1991 | Curr Eye Res1991，10，8： | 1 |
| 2 | Assisted machining of carbon fiber reinforced polymers 显示文摘 | ZEMANN R KAIN L BLEICHER F | 2014 | Procedia Engineering2014，，69： | 1 |
| 3 | Recombinant Human Receptors and Functional Assays in the Discovery of Altinicline (SIB-1508Y), a Novel Acetylcholine-gated ion Channel (nAChR) Agonist显示文摘 | COSFORD ND BLEICHER L VERNIER JM | 2000 | Pharm Acta Heir(S0031- 6865)2000，74，23： | 1 |
| 4 | Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism显示文摘 | BLEICHER L de MOURA PR WATANABE L | 2008 | FEBS Lett2008，582，20： | 1 |
| 5 | Sequential expression of matrix protein genes in developing rat teeth 显示文摘 | Bleicher F Couble M L Farges JC | 1999 | Matrix Biol1999，18，2： | 1 |
| 6 | Odontoblast differentiation of human dental pulp cells in explant cultures显示文摘 | COUBLE M L FARGES J C BLEICHER F | 2000 | Calcif Tissue Int2000，66，2： | 1 |
| 7 | Prevalence of depression and anxiety and their risk factors in women with breast cancer in German primary care 显示文摘 | ENGELHARD J BLEICHER L KOSTEV K | 2015 | Value Health2015，18，7： | 1 |
| 8 | Sequential expression of matrix protein genes in developing rat teeth显示文摘 | Bleicher F Couble M L Farges J C | | Matrix Biology0，8，： | 1 |
| 9 | Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature显示文摘BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor prognosis.Evidence on optimal treatment is limited and surgical management varies widely.We hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several decades.AIM To update our understanding of outcomes for patients with ARM and analyze management trends around the world.METHODS This is a multi-institutional,retrospective study of patients treated for ARM at 7 hospitals.Hospitals included both large,academic,tertiary care centers and smaller,general community hospitals.Using prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May 2019.We analyzed factors prognostic for recurrence and survival.We then used Cox regression to measure overall survival(OS)and melanoma-specific survival.We also performed a literature review to assess trends in surgical management and outcomes.RESULTS Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at diagnosis.Median time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical resection.Median OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 years.Primary surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and India.There was no significant improvement in survival over time.CONCLUSION There is wide variation in the management of ARM and survival outcomes remain poor regardless of approach.Surgical management should aim to minimize morbidity. | Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L Bowles John R Hyngstrom Elliot A Asare | 2021 | World Journal of Gastroenterology2021，27，3： | 1 |
| 10 | Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism显示文摘 | Bleicher L de Moura PR Watanabe L | 2008 | FEBS Lett2008，582，20： | 1 |
| 11 | Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism显示文摘 | Bleicher L de Moura PR Watanabe L | 2008 | FEBS Lett2008，582，20： | 1 |
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