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| 1 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia显示文摘AIM:To evaluate blood concentration of melatonin and urinary excretion of its metabolite,6-sulfatoxymelatonin(6-OHMS),in functional dyspepsia(FD).METHODS:Ninety individuals were enrolled in the study:30 in each study group:patients with postprandial distress syndrome(PDS),epigastric pain syndrome(EPS),and controls.Blood samples were drawn at 02:00 and 09:00 h and 24-h urine collection was performed.Serum melatonin and urinary 6-OHMS concentrations were measured by enzyme-linked immunosorbent assay.RESULTS:Serum melatonin concentration at night and in the morning was significantly(P < 0.001) higher in PDS patients [at 02:00 h-93.3 pg/mL,quartile range(QR):79.8-116.2;at 09.00 h-14.3 pg/mL,QR:7.06-19.0] than in EPS(57.2 pg/mL,QR:42.6-73.1;8.1 pg/mL,QR:4.1-9.3) and control patients(57.7 pg/mL,QR:51.2-62.5;8.1 pg/mL,QR:5.4-10.3).A similar relationship was observed for urinary 6-OHMS excretion.Patients with severe PDS symptoms had a higher melatonin concentration than these with moderate syndromes,whereas patients with severe EPS had a lower urinary 6-OHMS excretion than patients with moderate symptoms.CONCLUSION:Evaluation of melatonin serum concentrations and 24-h urinary 6-OHMS excretion are useful methods for differential diagnosis of various clinical forms of FD. | Cezary Chojnacki Tomasz Poplawski Grazyna Klupinska Janusz Blasiak Jan Chojnacki Russel J Reiter | 2011 | World Journal of Gastroenterology2011，17，21： | 8 |
| 2 | Non-homologous DNA end joining显示文摘 | Pastwa E Blasiak J | 2003 | Acta Biochim Pol2003，50，4： | 1 |
| 3 | Genotoxicity of acrylamide in human lymphocytes 显示文摘 | BLASIAK J GLOC E WOZNIAK K | 2004 | Chem Biol Interact2004，149，23： | 1 |
| 4 | Non-homologous DNA end joining显示文摘 | Pastwa E Blasiak J | 2003 | Acta Biochim Pol2003，50，： | 1 |
| 5 | Non-homologous DNA end joining显示文摘 | BLASIAK J | 2003 | Acta Biochimica Polonica2003，50，4： | 1 |
| 6 | Genotoxicity of acrylamide in human lymphocytes显示文摘 | Blasiak J Gloc E Wozniak K | 2004 | Chem Biol Interact2004，149，23： | 1 |
| 7 | An association of polymorphism of DNA repair genes XRCC1 and XRCC3 with colorectal cancer显示文摘 | Krupa R Blasiak J | 2004 | J Exp Clin Cancer Res2004，23，2： | 1 |
| 8 | Non-homologous DNA end joining-new proteins,new functions,new mechanisms显示文摘 | Poplawski T Stoczyńska E Blasiak J | 2009 | Postepy Biochem2009，55，1： | 1 |
| 9 | Curcumin damages DNA in human gastric mucosa cells and lymphocytes 显示文摘 | BLASIAK J TRZECIAK A KOWALIK J | 1999 | J Environ Pathol Toxicol Oncol1999，18，4： | 1 |
| 10 | The role of microrna in metastatic colorectal cancer and its significance in cancer prognosis and treatment显示文摘 | Tokarz P Blasiak J | | 0，，04： | 1 |
| 11 | Melato- nin secretion and metabolism in patients with hepatic en- cephalopathy 显示文摘 | Chojnacki C Wachowska-Kelly P Blasiak J | 2013 | Journal of Gastroenterology and Hepatol- ogy2013，28，2： | 1 |
| 12 | Synergistic effect of vitamin C on DNA damage induced by cadmium显示文摘 | Blasiak J Trzeciak A Dziki A | 2000 | Gen Physiol Biophys2000，19，4： | 1 |
| 13 | Formation mechanism of levoglucosan and formaldehyde during cellulose pyrolysis显示文摘 | ZHANG X L LI J YANG W H BLASIAK W | 2011 | Energy Fuels2011，25，8： | 1 |
| 14 | Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration显示文摘 | Blasiak J Petrovski G Vereb Z | 2014 | Biomed Res Int2014，2014，76： | 1 |
| 15 | Zinc differentially modulates DNA damage induced by anthracyclines in normal and cancer cells显示文摘 | Wysokinski D Blasiak J Wozniak K | 2012 | Exp Oncol2012，34，4： | 1 |
| 16 | Pyrolysis characteristics and global kinetics of coconut and cashew nut shells显示文摘 | Alberto J Tsamba Weihong Yang Wlodzimierz Blasiak | 2006 | Fuel Processing Technology2006，87，： | 1 |
| 17 | Protective action of vitamin C against DNA damage induced by selenium2cisp latin conjugate 显示文摘 | Blasiak J Kowalik J | 2001 | Acta B iochim Pol2001，48，1： | 1 |
| 18 | Vitamin C and quercetin modulate DNA damaging effect of N-methyl-n'-nitro- n-nitrosoguanidine (MNNG)显示文摘 | Blasiak J Trzeciak A Gasiorowska A | 2002 | Plant Food Hum Nutr2002，57，1： | 1 |
| 19 | DNA damage and repair in human lymPhoeytes and gastric mucosa cells exposed to chromium and curcumin显示文摘 | Blasiak J Trzeciak A Malecka - Panas E | 1999 | Teratog Carcinog Mutagen1999，19，： | 1 |
| 20 | The role of microrna in metastatic colorectal cancer and its significance in cancer prognosis and treatment显示文摘 | Tokarz P Blasiak J | | 0，，04： | 1 |
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