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| 1 | 急性脑梗死静脉溶栓后早期神经功能恶化与血清白蛋白水平的关系研究显示文摘目的探讨急性脑梗死静脉溶栓后早期神经功能恶化(END)与血清白蛋白水平的关系。方法收集2017年1月至2018年8月发病4.5 h内接受阿替普酶静脉溶栓治疗患者的临床资料。根据是否出现END,分为恶化组和非恶化组,分析血清白蛋白水平与END发生的相关性。结果共纳入148例患者,其中恶化组39例,非恶化组109例。与非恶化组相比,恶化组总蛋白水平、白蛋白水平和淋巴细胞计数较低,且差异有统计学意义(P<0.05)。恶化组的中性粒细胞计数、红细胞分布宽度、国际标准化比值、纤维蛋白(原)降解产物以及入院时美国国立卫生研究院卒中量表(NIHSS)评分高于非恶化组,差异有统计学意义(P<0.05)。恶化组多伴有心房颤动,且两组在血管狭窄程度及梗死部位方面比较差异也有统计学意义(P<0.05)。多因素Logistic回归分析显示,血清白蛋白(OR=0.873,95%CI 0.768~0.993)、入院时NIHSS评分(OR=1.120,95%CI 1.008~1.245)、中性粒细胞计数(OR=1.271,95%CI 1.048~1.542),以及心源性卒中和责任血管狭窄程度均可能影响急性脑梗死静脉溶栓的短期预后。出院时改良Rankin量表(mRS)评分(平均14 d)与白蛋白水平呈显著负相关(r=-0.205,P=0.013)。结论相比于非恶化患者,恶化患者的白蛋白水平较低。高水平的血清白蛋白是急性缺血性脑卒中静脉溶栓后END的保护因素。血清白蛋白水平与患者的短期预后存在相关性,白蛋白水平越低,mRS评分越高,预后越差。 | 钱新宇 吕金峰 Bilal Muhammad 杜波 耿德勤 | 2019 | 中国医师进修杂志2019，42，4： | 33 |
| 2 | Indoleamine 2,3-dioxygenase: As a potential prognostic marker and immunotherapeutic target for hepatocellular carcinoma显示文摘Tumor cells induce an immunosuppressive microen-vironment which leads towards tumor immune escape. Understanding the intricacy of immunomodulation by tumor cells is essential for immunotherapy. Indoleamine 2,3-dioxygenase(IDO) is an immunosuppressive enzyme which mediates tumor immune escape in various cancers including hepatocellular carcinoma(HCC). IDO up-regulation in HCC may lead to recruitment of regulatory T-cells into tumor microenvironment and therefore inhibit local immune responses and promote metastasis. HCC associated fibroblasts stimulate natural killer cells dysfunction through prostaglandin E2 and subsequently IDO promotes favorable condition for tumor metastasis. IDO up-regulation induces immuno-suppression and may enhance the risk of hepatitis C virus and hepatitis B virus induced HCC. Therefore, IDO inhibitors as adjuvant therapeutic agents may have clinical implications in HCC. This review proposes future prospects of IDO not only as a therapeutic target but also as a prognostic marker for HCC. | Kashif Asghar Asim Farooq Bilal Zulfiqar Muhammad Usman Rashid | 2017 | World Journal of Gastroenterology2017，23，13： | 16 |
| 3 | Micro RNAs in colorectal cancer:Role in metastasis and clinical perspectives显示文摘Colorectal cancer(CRC)is the third most common malignancy and the third leading cause of cancer related deaths in the United States.Almost 90%of the patients diagnosed with CRC die due to metastases.Micro RNAs(mi RNAs)are evolutionarily conserved molecules that modulate the expression of their target genes post-transcriptionally,and they may participate in various physiological and pathological processes including CRC metastasis by influencing various factors in the human body.Recently,the role mi RNAs play throughout the CRC metastatic cascade has gain attention.Many studies have been published to link them with CRC metastasis.In this review,we will briefly discuss metastatic steps in the light of mi RNAs,along with their target genes.We will discuss how the aberration in the expression of mi RNAs leads to the formation of CRC by effecting the regulation of their target genes.As mi RNAs are being exploited for diagnosis,prognosis,and monitoring of cancer and other diseases,their high tissue specificity and critical role in oncogenesis make them new biomarkers for the diagnosis and classification of cancer as well as for predicting patients’outcome.Mi RNA signatures have been identified for many human tumors including CRC,and mi RNA-based therapies to treat cancer have been emphasized lately.These will also be discussed in this review. | Shan Muhammad Kavanjit Kaur Rui Huang Qian Zhang Paviter Kaur Hamza Obaid Yazdani Muhammad Umar Bilal Jiang Zheng Liu Zheng Xi-Shan Wang | 2014 | World Journal of Gastroenterology2014，20，45： | 13 |
| 4 | 直流GIL中线形金属微粒电动力学行为研究显示文摘直流GIL中线形金属微粒受力运动极易引发气体间隙击穿或者绝缘子沿面闪络,降低GIL的绝缘性能,严重影响直流输电系统的安全可靠运行。为研究直流GIL中线形金属导电微粒电动力学行为机理,搭建自由微粒实验装置和观测平台,并建立直流下微粒电动力学模型。通过实验与仿真相结合的方法,获得线形金属微粒荷电特性、启举与运动特性以及微粒运动导致的气隙击穿特性,并从微观角度解释了微粒启举与运动现象形成的原因。研究结果表明,线形启举电压只与半径有关,与长度和电压极性无关,随着半径增大,启举电压升高,直流电压极性不影响金属微粒启举电压幅值;线形微粒的运动及导致的气隙击穿与微粒半径、长度和电压极性有关,线形金属微粒半径小、长度增加时容易导致气隙击穿;线形金属微粒形状的不规则使得电场畸变作用加强,极性效应更明显。电晕极性效应导致正负极性下线形微粒的启举与运动及运动致气隙击穿特性呈现出明显的规律,当达到启举电压时,正极性下,线形金属微粒一端抬起后,在下极板小幅跳跃、旋转或者直立,难以贯穿气隙;负极性下,线形金属微粒贯穿气隙运动,极易出现飞萤现象,为直流GIL中线形金属微粒污染防治提供了理论指导。 | 程涵 魏威 Bilal lqbal Ayubi 孙优良 张黎 | 2021 | 电工技术学报2021，36，24： | 12 |
| 5 | Fabrication of NiFe layered double hydroxide with well-defined laminar superstructure as highly efficient oxygen evolution electrocatalysts显示文摘Structure-activity relationship (SAR) is the key problem of nanoscience,thus to fabricate novel and well-defined nanostructure will provide a new insight on catalyst preparation method.Highly active and low cost electrocatalysts for oxygen evolution reaction (OER) are of great importance for future renewable energy conversion and storage.Herein,NiFe-based layered double hydroxides with laminar structure (NFLS) were successfully fabricated via a one-step hydrothermal approach by using sodium dodecyl sulfate as surfactant.The as-fabricated NFLS showed a well-defined periodic layered-stacking geometry with a scale down to 1-nm.Benefitting from the unique structure,NFLS exhibited an excellent catalytic activity towards OER with current densities of 10 mA·cm^-2 at overpotential of 197 mV.The synergistic effect of Ni and Fe plays a key role in electrode reactions.The present work provides a new insight to improve the OER performance by rational design of electrocatalysts with unique structures. | Hao Zhang Haoyi Li Bilal Akram Xun Wang | 2019 | Nano Research2019，12，6： | 10 |
| 6 | 城乡教育一体化背景下乡村小规模学校布局调整与优化建议——基于陕西省宁强县的案例分析显示文摘我国义务教育正在由优质均衡向城乡一体化发展迈进,作为乡村地区常态化办学形式的小规模学校,其空间布局合理化直接决定着广大乡村儿童能否就近入学、公平享有优质教育的机会。研究基于陕西省宁强县的微观数据,采用GIS技术方法,从地理位置、服务范围、家校距离、上学可达性等维度动态分析小规模学校布局变化和存在的问题:城乡教育一体化发展中公平与效率冲突,布局过于分散,撤并后儿童上学距离加大且承担较高成本,保留的小规模学校与县镇学校办学资源差距依然较大且合作网络缺失。由此,各级教育行政部门应在城乡义务教育布局统筹中坚持公平优先、效率兼顾、质量导向的价值取向, 采用科学的规划程序和调整模式,合理撤并和保留小规模学校, 加强政策支持,补偿偏远地区儿童求学成本, 构建校际合作网络,促进小规模学校共享优质资源。 | 赵丹 郭清扬 Bilal Barakat | 2021 | 中国教育学刊2021，，5： | 10 |
| 7 | Assessment of sunflower germplasm for phytoremediation of lead-polluted soil and production of seed oil and seed meal for human and animal consumption显示文摘Phytoremediation is a valuable technology for mitigating soil contamination in agricultural lands,but phytoremediation without economic revenue is unfeasible for land owners and farmers.The use of crops with high biomass and bioenergy for phytoremediation is a unique strategy to derive supplementary benefits along with remediation activities.Sunflower(Helianthus annuus L.)is a high-biomass crop that can be used for the phytoremediation of polluted lands with additional advantages(biomass and oil).In this study,40 germplasms of sunflower were screened in field conditions for phytoremediation with the possibility for oil and meal production.The study was carried out to the physiological maturity stage.All studied germplasms mopped up substantial concentrations of Pb,with maximum amounts in shoot>root>seed respectively.The phytoextraction efficiency of the germplasm was assessed in terms of the Transfer factor(TF),Metal removal efficiency(MRE)and Metal extraction ratio(MER).Among all assessed criteria,GP.8585 was found to be most appropriate for restoring moderately Pb-contaminated soil accompanied with providing high biomass and high yield production.The Pb content in the oil of GP.8585 was below the Food safety standard of China,with 59.5% oleic acid and 32.1% linoleic acid.Moreover,amino acid analysis in meal illustrated significant differences among essential and nonessential amino acids.Glutamic acid was found in the highest percentage(22.4%),whereas cysteine in the lowest percentage(1.3%).Therefore,its efficient phytoextraction ability and good quality edible oil and meal production makes GP.8585 the most convenient sunflower germplasm for phytoremediation of moderately Pb-contaminated soil,with fringe benefits to farmers and landowners. | Afsheen Zehra Zulfiqar Ali Sahito Wenbin Tong Lin Tang Yasir Hamid Muhammad Bilal Khan Zarina Ali Beena Naqui Xiaoe Yang | 2020 | Journal of Environmental Sciences2020，32，1： | 10 |
| 8 | Hepatocellular carcinoma review:Current treatment,and evidence-based medicine显示文摘We read with great interest the recent article entitled'Hepatocellular carcinoma review:Current treatment,and evidence-based medicine'by Raza et al,published in World Journal of Gastroenterology.Authors evaluated treatments for early and advanced stage hepatocellular carcinoma based on an extensive review of the relevant literature.They reported that radiofrequency ablation is the most effective local ablative therapy.They concluded that RF ablation is equivalent to surgical resection in well selected patients with early stage hepatocellular carcinoma.In addition,we want to mention microwave ablation besides RF ablation. | Bulent Karaman Bilal Battal Sebahattin Sari Samet Verim | 2014 | World Journal of Gastroenterology2014，20，47： | 9 |
| 9 | Role of flavonoids in plant interactions with the environment and against human pathogens-A review显示文摘Flavonoids are widely-distributed polyphenolic secondary metabolites with diverse biological activities in plants and benefit human health as protective dietary agents.They participate in plants' responses to harsh environmental conditions and effectively regulate the cell differentiation and growth.In plants,the majority of their functions are attributed to their strong antioxidative properties.Similarly,dietary flavonoids protect the human body against free radicals which are associated with the development of cancer and atherosclerosis.Plants rich in polyphenols have been used to cure various diseases because of their antibacterial,antiviral,antifungal and anticancer properties.This review summarizes the up-to-date research trends and development on flavonoids and its derivatives,working mechanisms and potential functions and applications particularly in relation to plant protection and human health.Towards the end,notable concluding remarks with a close-up look at the future research directions have also been presented briefly. | Muhammad Khalid Saeed-ur-Rahman Muhammad Bilal HUANG Dan-feng | 2019 | Journal of Integrative Agriculture2019，18，1： | 8 |
| 10 | Isolation and efficacy of entomopathogenic fungus(Metarhizium anisopliae)for the control of Aedes albopictus Skuse larvae:suspected dengue vector in Pakistan显示文摘Objective:To isolate the entomopathogenic fungus Metarhixium anisopliae(M.anisopliae) in the local environment,and evaluate its efficacy against the suspected dengue vector Aedes albopictus in Pakistan.Methods:According to the standard procedure,M.anisopliae was isolated from the dead mosquitoes which were collected from the field or dead after the collection.Bioassay was performed to determine its efficacy.Results:The results indicated that M.anisopliae had larvicidal effect with LC,value 1.09×10~5 and LC_(50) value 1.90×10^(13) while it took 45.41 h to kill 50% of tested population.Conclusions:Taking long time to kill 50%population when compare with the synthetic insecticides,is the only drawback for the use of entomopathogenic fungus but these bio-pesticides are safe for the use. | Hazrat Bilal Soaib Ali Hassan Imtinan Akram Khan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 8 |
| 11 | Anatomy of a eustatic event during the Turonian (Late Cretaceous) hot greenhouse climate显示文摘Sequence stratigraphic studies consider relative change in sea level(as regulated by eustasy,local tectonics and sediment supply)as the main builder of the stratigraphic record.Eustasy has generally been considered as a consequence of the growth and decay of continental ice sheets that would explain large,rapid changes in sea level,even during periods of relative global climatic warmth.However,such a mechanism has become increasingly difficult to envision during times of extreme global warmth such as the Turonian,when the equator-to-pole temperature gradient was very low and the presence of polar ice seems improbable.This paper investigates the timing and extent of sea level falls during the late Cenomanian through Turonian,especially the largest of those events,sequence boundary KTu4,which occurred during the middle to late Turonian peak of the Cretaceous hot greenhouse climate.We conclude that the amplitude of the widespread third-order sea level fall in the middle Turonian that is centered at^91.8 Ma varies at different locations depending on the influence of dynamic topography on local tectonics and regional climatic conditions.Ice volume variations seem unlikely as a mechanism for controlling sea level at this time.However,this causal factor cannot be ruled out completely since Antarctic highlands(if they existed in the Late Cretaceous)could sequester enough water as ice to cause eustatic falls.To ascertain this requires detailed tomographic imaging of Antarctica,followed by geodynamic modeling,to determine whether high plateaus could have existed to accumulate ephemeral ice sheets.Other mechanisms for sea level change,such as transference between ground water(a small amplitude shorter time scale effect)and the ocean and entrainment and release of water from the mantle to the oceanic reservoir(a potentially large amplitude and longer time scale process),are intriguing and need to be explored further to prove their efficacy at third-order time scales. | Bilal U. HAQ Brian T. HUBER | 2017 | Science China Earth Sciences2017，60，1： | 8 |
| 12 | Evaluation and management of acute pancreatitis显示文摘Acute pancreatitis(AP) is one of the most common gastrointestinal causes for hospi-talization in the United States. In 2015, AP accounted for approximately390000 hospitalizations. The burden of AP is only expected to increase over time.Despite recent advances in medicine, pancreatitis continues to be associated with a substantial morbidity and mortality. The most common cause of AP is gallstones, followed closely by alcohol use. The diagnosis of pancreatitis is established with any two of three following criteria:(1) Abdominal pain consistent with that of AP;(2) Serum amylase and/or lipase greater than three times the upper limit of normal; and(3) Characteristics findings seen in crosssectional abdominal imaging. Multiple criteria and scoring systems have been established for assessing severity of AP. The cornerstones of management include aggressive intravenous hydration, appropriate nutrition and pain management.Endoscopic retrograde cholangiopancreatography and surgery are important aspects in management of acute gallstone pancreatitis. We provide a comprehensive review of evaluation and management of AP. | Ahmed T Chatila Mohammad Bilal Praveen Guturu | 2019 | World Journal of Clinical Cases2019，7，9： | 8 |
| 13 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 14 | Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer显示文摘The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells. | Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena Jaggi Murali M.Yallapu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 7 |
| 15 | NUMERICAL SIMULATION OF AN OSCILLATING FLOW PAST A CIRCULAR CYLINDER IN THE VICINITY OF A PLANE WALL显示文摘Oscillating flow around a circular cylinder in the vicinity of a plane wall was investigated by solving the two-dimensional incompressible Navier-Stokes equations with a finite element Galarkin residual method. The effect of the gap G D between the cylinder surface and the wall on the flow behavior was studied. For the case of G D ≤ 0.25, the periodicity in the flow is attributed to both the outer shear layer instability and the oscillating frequency. As G D > 0.25, vortex shedding occurs and the periodicity in the flow is mainly due to the competition of the oscillating frequency and the vortex shedding frequency from an isolated stationary cylinder. | SHAH Syed Bilal Hussain | 2008 | Journal of Hydrodynamics2008，20，5： | 7 |
| 16 | Engineering the Smart Factory显示文摘The fourth industrial revolution promises to create what has been called the smart factory. The vision is that within such modular structured smart factories, cyber-physical systems monitor physical processes, create a virtual copy of the physical world and make decentralised decisions. This paper provides a view of this initiative from an automation systems perspective. In this context it considers how future automation systems might be effectively configured and supported through their lifecycles and how integration,application modelling, visualisation and reuse of such systems might be best achieved. The paper briefly describes limitations in current engineering methods, and new emerging approaches including the cyber physical systems(CPS) engineering tools being developed by the automation systems group(ASG) at Warwick Manufacturing Group, University of Warwick, UK. | HARRISON Robert VERA Daniel AHMAD Bilal | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 7 |
| 17 | 溶栓后中性粒细胞升高与缺血性脑卒中早期神经功能恶化相关性研究显示文摘目的探讨溶栓后中性粒细胞升高与缺血性脑卒中早期神经功能恶化(early neurological deterioration,END)发生的相关性。方法收集2017年1月-2018年11月的发病4.5 h内接受阿替普酶静脉溶栓治疗患者的临床资料。根据是否出现END,分为END组和非END组,观察两组患者溶栓前后中性粒细胞、淋巴细胞等指标的变化,以探讨基线及溶栓后中性粒细胞、淋巴细胞和中性粒细胞/淋巴细胞比率与END的相关性。结果共纳入患者187例,其中END组48例,非END组139例。溶栓前,两组患者除总蛋白(t=2.130,P=0.035)、白蛋白(t=2.777,P=0.007)外,其余指标比较差异均无统计学意义(P>0.05)。溶栓后,白细胞计数、中性粒细胞计数、中性粒细胞/淋巴细胞比值、纤维蛋白酶降解产物、基线和变化美国国立卫生研究院卒中量表评分、心源性脑卒中、责任血管狭窄程度及前循环皮质梗死部位,END组均高于非END组(P<0.05);而总蛋白、白蛋白、淋巴细胞计数、前白蛋白END组低于非END组(P<0.05)。溶栓前后,END组中性粒细胞增加明显(Z=-2.314,P=0.021)。中性粒细胞计数[比值比=1.288,95%置信区间(1.069,1.552)]为静脉溶栓END的独立影响因素之一;且预测END的特异度最高(灵敏度为62.5%,特异度为71.9%)。结论溶栓后中性粒细胞升高与END的发生有一定相关性。动态监测静脉溶栓治疗后的中性粒细胞可有助于预测END的发生。 | 钱新宇 杨思远 Bilal Muhammad 杜波 耿德勤 | 2019 | 华西医学2019，34，6： | 7 |
| 18 | 睾酮和良性前列腺增生症显示文摘由于医患双方对于男性迟发性腺功能减退症状的警觉,使得近期针对此类患者的睾酮治疗增多。但是考虑到睾酮治疗对前列腺的影响,尤其可能增加前列腺癌发病风险,促进了该方面的研究进展。出乎意料的是大量的回顾性或小样本随机研究提示睾酮治疗或可改善男性下尿路症状。虽然此改善的确切机理仍在争论中,但或许和代谢综合征密切相关。对于临床医生,这些研究的结果虽然让人期待,但是缺乏高等级证据支持。因此在诊断迟发性腺功能减退症或考虑睾酮治疗前,仍需对患者进行包括病史、体检和睾酮测量在内的全面临床检查。睾酮补充治疗可能导致尿潴留和加重下尿路症状,这些产品说明上标注的风险依然存在,应该在用药前向患者解释说明。 | Thomas R Jarvis Bilal Chughtai Steven A Kaplan | 2015 | Asian Journal of Andrology2015，17，2： | 7 |
| 19 | 荧光介孔二氧化硅负载丙硫菌唑纳米颗粒的制备及性能研究显示文摘近年来,丙硫菌唑作为一种新颖的广谱杀菌剂备受关注,但由于其代谢产物对操作人员存在健康风险,导致其在中国的使用和登记受到限制。将丙硫菌唑制备为具有缓慢释放、可提高农药稳定性等特点的缓释制剂可有效改善其带来的健康风险问题。本研究采用纳米荧光介孔二氧化硅制备了丙硫菌唑缓释纳米颗粒,通过扫描电镜(SEM)、透射电镜(TEM)、傅里叶变换红外光谱(FTIR)、X-射线光电子能谱(XPS)、Brunauer-Emmett-Teller(BET)比表面积分析、热重分析(TGA)、荧光光谱以及高效液相色谱仪等手段对其结构与特性进行表征。采用透析袋法探讨了丙硫菌唑在释放介质中的释放行为;利用菌丝生长速率法测定了该载药颗粒对小麦赤霉病原菌的杀菌活性;通过激光共聚焦研究了荧光二氧化硅在小麦赤霉病菌菌丝体以及小麦中的传输情况。结果表明:所制备的载药纳米颗粒外观形貌较为规整,平均粒径为139 nm,其最大载药量可达27.14%;该纳米载药颗粒具有缓释性能,释放曲线符合Ritger-Peppas方程;载药颗粒与丙硫菌唑原药相比具有相同的毒力效果。此外,激光共聚焦结果表明,该荧光二氧化硅纳米颗粒可以在菌丝体以及小麦植株根部吸收和传导。 | 许春丽 Muhammad BILAL 徐博 冉刚超 赵鹏跃 曹冲 李凤敏 曹立冬 黄啟良 | 2020 | 农药学学报2020，22，2： | 6 |
| 20 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
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