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| 1 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 2 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 3 | Imaging of primary central nerv- ous system lymphoma 显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clinical radiology2011，66，： | 1 |
| 4 | A review of ontology based query expansion显示文摘 | Bhogal J Macfarlane A Smith P | 2007 | Information processing & management2007，43，4： | 1 |
| 5 | Imaging of primary central nerv- ous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，： | 1 |
| 6 | A review of on- tology based query expansion 显示文摘 | Bhogal J Maefarlane A Smith P | 2007 | Inf Proc Man- age2007，43，4： | 1 |
| 7 | Imaging of primary central nervous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，8： | 1 |
| 8 | Lichen planus pemphigoides: its relationship to bullous pemphigoid显示文摘 | Davis AL Bhogal B S Whitehead P | 1991 | Br J Dematol1991，125，： | 1 |
| 9 | Patients with subarachnoid haemorrhage from vertebmbasilar dissection: treatment with stent-in-stent technique 显示文摘 | Bhogal P Bmuwer PA Stderqst K | 2015 | Neuroradiology2015，57，6： | 1 |
| 10 | Systematic investigation on the interaction of bovine serum albumin with ZnO nanoparticles using fluorescence spectroscopy显示文摘 | BHOGALE A PATEL N SARPOTDAR P | 2013 | Colloids Surf B:Biointerfaces2013，102，： | 1 |
| 11 | Imaging of primary central nervous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，8： | 1 |
| 12 | Imaging of primary central nerv- ous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，： | 1 |
| 13 | Imaging of prima- ry central nervous system lymphoma 显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiot2011，66，8： | 1 |
| 14 | A review of ontology based query expansion 显示文摘 | Bhogal J Macfarlane A Smith P | 2007 | Information Processing and Management2007，43，4： | 1 |
| 15 | Imaging of primary central nervous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，8： | 1 |
| 16 | Imaging of primary central system lymphoma显示文摘 | Tang YZ Booth Tc Bhogal P | 2011 | Clin Radiol2011，66，8： | 1 |
| 17 | Imaging of primary central nerv- ous system lymphoma 显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clinical Radiology2011，66，8： | 1 |
| 18 | Imaging of primary central nervous system lymphoma显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，： | 1 |
| 19 | Consequences of feasible future agricultural land-use change on soil or- ganic carbon stocks and greenhouse gas emissions in Great Britain显示文摘 | Smith P Bhogal A Edgington P | 2010 | Soil Use and Management2010，26，4： | 1 |
| 20 | Imaging of primary central nervous system lymphoma 显示文摘 | Tang YZ Booth TC Bhogal P | 2011 | Clin Radiol2011，66，8： | 1 |
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